I agree Miguel's tutorial is fantastic for a step-by-step walkthrough. He also has a video to cover much of the material: http://pyvideo.org/video/2608/flask-by-example

If you're going down the Python route I'll throw in Full Stack Python http://www.fullstackpython.com/ I wrote FSP to provide beginners with context as to what these terms like web server, WSGI server and platform-as-a-service mean without assuming you have prior programming experience.

He now has a book, too: http://www.amazon.com/Flask-Web-Development-Developing-Appli...

Uhhh, thank you. I was interested in using Python, since it seems so omnipresent when you look at the it security space. So this might be a great alternative to PHP (at least for me...)