Prezi focuses too much on transitions between the slides and I really don't like it much

The MS Office suite in general is incredibly overcomplicated for what the average person is actually going to need or even use. The ribbon interface I think helped (mainly because it removed/hid Clipart and Wordart), but not enough. Many people I know have stopped using Office entirely in favour of the free and much lighter weight Google Docs suite, with no complaints about missing features.

MS does seem to be simplifying (or arguably dumbing down) their interfaces a lot these days, so maybe we'll see this kind of a redesign.

To an extent. I use iPython with RISE or a deck.js based system. I really like the deck.js method because my interface is vim.