If you try to press on what people believe "significant" to mean it gets ugly fast, but it's generally a good thing and definitely necessary to publish. If you don't get significance it's just because you need a bigger n. If you can think of some factors or covariates then you really need to use ANOVA.
Stating that there is anything more complex to looking at data and deciding what it means is practically unthinkable.
Likelihood ratios are definitely nice, though. I've sort of gotten people to think about it at a high level by talking about "information flows" and log likelihood values.