One of the best starting points for building a SPA that I've seen is the Angular Fullstack generator https://github.com/DaftMonk/generator-angular-fullstack

This generator uses Angular best practices, has Jasmine and Karma built in for solid unit and integration (called e2e tests in Angular) testing. The built-in generators even build pages, controllers, and add the unit test files along with the new routes. In addition, authentication via Passport.js is in the box. In my opinion it's an easy to extend, robust solution for building a non-trivial SPA. Even has hooks for easy deployment to Heroku.

That being said, I have been trying to learn React lately and have yet to find a similar thing for a React-based stack.