I just looked at the live map for the SF area. A Temporary Flight Restriction over most of SF begins in 39 minutes, surface to 3000 feet, because there is a baseball game at the ballpark.
Autonomous drone operations in urban areas are going to be very tough to control. Drones are going to need their own airborne radar. Maybe only a hundred meters of range, but they're going to need to be able to see details down to power lines. This is available now, but needs more downsizing.[1]
What might work is a system where all manned aircraft have ADS-B (this is coming) and drones also have ADS-B and enough smarts to stay well out of the way of anything bigger. Drones also need short-range radar so they can avoid bumping into obstacles and each other. Think of this as "micro-see-and-be-seen'. It's a lot of electronics to carry, but less electronics than a smartphone.
This is more likely to work than some scheme where everybody phones home to Amazon's cloud.
[1] http://www.autonomoustuff.com/sms-radar-proximity-warning-sy...