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Gooblebrai

1,344 karma · joined August 5, 2018

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Gooblebrai··on The brain may be about to have its Ozempic moment
Indeed. Pain is also interesting because chronic pain, AFAIK is sometimes a misfiring of pain signals even when nothing is physically wrong.

Turning off that misfiring with drugs would be dangerous (pain is an alert) but also improve the quality of life of so many people!

Gooblebrai··on The brain may be about to have its Ozempic moment
What has anything in this article to do with Ozempic? Is mentioned in the title once and never again. Engagement bait?
Gooblebrai··on The brain may be about to have its Ozempic moment
If you don't feel tired, are you really? I'm curious what are the objective metrics to determine someone is tired
Gooblebrai··on How to organize Claude Code for product work
Relevant.

What is a product? 106 points by rogix 4 days ago | 68 comments https://news.ycombinator.com/item?id=49202690

Gooblebrai··on Ask HN: What are you working on? (August 2026)
What job queue system do you use that works with Postgres?
Gooblebrai··on What happens if an entire class of workers loses faith in their careers
> how incredibly toxic the web has become

A reflection of human nature at scale?

Gooblebrai··on Show HN: textlog – A quiet, text-only microblogging platform, open-source, no JS
That's how enshittification begins. Next thing you know and there are blue badges next to profiles.
Gooblebrai··on Why Is Everyone in Tech So Sad?
Very good reading. Thanks for sharing!
Gooblebrai··on What is a product?
> If nobody is using the thing you built, you don't have a product, you have a toy

Hard disagree. I think the articles goes in a good direction when it comes to the question but this ending is short of a satisfying answer

Gooblebrai··on Herdr is joining Y Combinator. The runtime stays open
I thought the A2A protocol from Google would solve this of our personal agents speaking with company agents
Gooblebrai··on Qwen3.8 Max now ranked as the best overall model by agentic index
Found the usage limits on OpenCode Go quite poor tbh
Gooblebrai··on Qwen3.8 Max now ranked as the best overall model by agentic index
Is there any subscription of any kind for Qwen? Or via Pi.dev needs to be used with API credits?
Gooblebrai··on Karpathy’s Pelican
I can't believe the video demo is $10
Gooblebrai··on Ask HN: What do you do when your AI agents are working?
Drink coffee
Gooblebrai··on Ask HN: Is neuromorphic computing going to replace traditional AI?
Thanks for the comment. Even if they don't compete with traditional LLMs and CNNs, do the people you spoke with see any potential breakthrough application of this type of chip?
Gooblebrai··on Apple sues OpenAI, accuses ex-employees of stealing trade secrets
Spot on
Gooblebrai··on Why is music so much easier for AI than code?
> It seems that music is so hard, why is it ai has already surpassed us there but not in code? Seems that code is easier.

I note by this that you don't seem to have experience in music? Because in that case, you are not equipped to judge the quality of the song at some levels beyond a listen.

The same way that someone not technical can't judge the code output of the LLM and will just be impressed by the functional output (i.e. is the site working)

Gooblebrai··on 60% Fable cost cut by converting code to images and having the model OCR it
Claude Science has a tool to extract the PDF but not sure if it's OCR'ing it.
Gooblebrai··on Instead of banning AI, I made a classroom contract with my students
Great comment! I'm sharing this around my circles.
Gooblebrai··on For first time, a cell built from scratch grows and divides
> It’s an unusual way of doing things,” says Kerstin Göpfrich, a synthetic biologist at Heidelberg University

Can't blame her if she wants her line of research to stay alive

Gooblebrai··on Steam Machine launches today
That crosses the line to elitism
Gooblebrai··on OpenAI Losses Increased Nearly 8X in 2025, with Spending Hitting $34B
> Unless we are genuinely pushing to find AGI, at which point nothing matters

I think the third coming out Jesus Christ in closer than AGI. Seriously, I dread how much of Silicon Valley is wrapped in this narrative of AGI and Singularity.

How can all these "rationalists" fail to see that this is what religion looks like: Faith and promises of heaven and hell.

Gooblebrai··on The founder's playbook: Building an AI-native startup
As said in Seinfeld: "Jerry, just remember. Is not a lie, if you believe it"
Gooblebrai··on The founder's playbook: Building an AI-native startup
> Which makes no sense the way they sell it, because "founding a business" is no standard process that could be formalized in a way like that

It makes no sense, but most technical people wished it could be like that and that's who this article is aimed at

Gooblebrai··on Ask HN: Would you want to know when and how you die?
These are the philosophical takes I love as answers to these hypothetical scenarios
Gooblebrai··on What I have done with Claude Code in the last 60 days being a non tech person
> I am just mind blown if a non tech person like me can do this much then what's the ceiling for people who are Technical

Slight irrelevant because when it comes to business, the most important part is finding customers and selling to them. Tech people focus too much on product development and neglect sales.

Gooblebrai··on Ask HN: Did Anthropic Just Win?
Not on image generation
Gooblebrai··on Making peace with your unlived dreams (2023)
Any specific recommendations?
Gooblebrai··on Biohub releases a world model of protein biology
The world of uncertainty and the idea that we might not be able to understand everything or control it as much as we'd like.

It seems to me a lot of the modern "tech-bro culture" is trying to control the future and reduce uncertainty: Stop death, merge with the robotic super intelligence, colonize Mars to escape Earth inevitable decay, etc.

I'm still waiting for the startups claiming to reduce entropy or solve the false vacuum decay

Gooblebrai··on Artificial intelligence is not conscious – Ted Chiang
Strange Days
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