Here you have some interesting work from Fabien Duchene, ENSIMAG/CEA researcher, about black-box genetic fuzzing (I know it sounds like a lot of buzzwords, and in fact it was a little bit mocked during SSTIC 2016, but it's some really good stuff !)
http://hal.univ-grenoble-alpes.fr/hal-00978844/ https://dl.acm.org.sci-hub.cc/citation.cfm?id=2557550&dl=ACM...