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JacobDotVI

396 karma · joined February 10, 2017

Successful entrepreneur tackling the data at the intersection of healthcare and life sciences. President of Flyrbidge.vi & VP Product @ USRetina

Previously: DARPA Grand Challenge, US Naval Research Lab, co-founder Kinsail Corp (acquired '14), and Cancer Treatment Centers of America and Co-founder Superconductive Health. hello at jacob dot vi

http://jacob.vi

http://flybridge.vi

submissionscomments
JacobDotVI··on Ask HN: What interesting stuff are you browsing?
Http://marginalrevolution.com - lots of interesting links and commentary.
JacobDotVI··on Ask HN: What's your quarantine side project?
I have spent every quarantine weekend in the yard and it's been magnificent and extremely rewarding. We had previously built raised beds but had limited success due to lack of regular watering so my first priority was repairing my entire drip line system and then extending it to the beds. Success!

Glad to hear others have garden / yard side projects as well. best of luck with the harvest.

JacobDotVI··on May Sky Challenge
Historically old-fashioned newspapers haven't had a calm perspective. Their headlines were the original clickbait.

https://en.wikipedia.org/wiki/Yellow_journalism

JacobDotVI··on Ask HN: Great fiction books that have had a positive impact on your life?
Great book - I took away a great appreciation for empathy or when it may be impossible.
JacobDotVI··on Ask HN: Great fiction books that have had a positive impact on your life?
Player Piano is such a good read today - puts all of automation fears and UBI arguments in the context of these are the same fears we have with every new technology.
JacobDotVI··on Poor man's document camera for videoconference
Not all video apps respect the lock orientation setting
JacobDotVI··on Ask HN: Book recommendations for understanding financial systems?
House of Morgan - biography of JO Morgan and kin

Snowball - biography of Warren Buffet

The Good Earth - novel about Chinese farmer

Fortune’s Children - the rise and fall of the Vanderbilts

JacobDotVI··on One Medical S-1
What happened to customer A and B?

Edit: My question is what caused these corporate customers to churn? Did they maintain spend levels with One Medical while the other customers grew spend? Did they decrease spend below reporting thresholds? Did they stop using (or sponsoring) these services entirely?

JacobDotVI··on Latency/throughput tradeoffs, illustrated with coffee
I'm not sure where you are from, but when I encountered one of these bridge in Kawaii, Hawaii a few years back it had specific instructions to follow the car in-front of you. I always admired whomever had the foresight to design such instructions and never realized it was not like that elsewhere.

From a quick google, looks like this is the the norm throughout Hawaii:

https://www.hawaii-aloha.com/blog/2014/01/08/one-lane-bridge...

https://vacations.hawaiilife.com/blog/misc/one-lane-bridge-e...

JacobDotVI··on Kurt Vonnegut Museum Opens in Indianapolis
Player Piano is a fantastic book and very topical in today's world awash in UBI, fears of automation, etc. Player piano is the GE's factory will take all jobs version of today's AI FUD.
JacobDotVI··on 40% of multinational profits are shifted to tax havens each year
Case in point: New Yorkers moving to Florida and Californians moving to Nevada.
JacobDotVI··on ‘Walter Ralegh: Architect of Empire’ Review: The Enlightened Adventurer
Tyler Cowen recently praised this book as well: https://marginalrevolution.com/marginalrevolution/2019/11/wa...
JacobDotVI··on Opioid crisis: Johnson and Johnson hit by landmark ruling
Turns out doctors have better opioid options today but not all of them take advantage of such an option.

https://marginalrevolution.com/marginalrevolution/2019/05/ho...

>In August of 2010, Purdue Pharma replaced old OxyContin with a new, anti-abuse version of OxyContin. The new version was just as good at reducing pain as the old but it was more difficult to turn it into an injectable to produce a high. If physicians are altruists who balance treating their patient’s pain against their fear of patient addiction and downstream abuse then they should increase their prescriptions of new Oxy. From the point of view of health, the new Oxy is simply a better drug and with less abuse to worry about altruistic physicians should be more willing on the margin to prescribe Oxy to reduce pain. So what happened? Prescriptions for Oxy fell immediately and dramatically when the better version was released.

JacobDotVI··on Show HN: Kähler Bank.X – AI-driven M and A Advisory for software startups
Sparse announcement blog post from Feb: https://medium.com/@Zaiku/welcoming-kähler-ai-b11a3fe152b7
JacobDotVI··on Scientists cook up new recipes for taking salt out of seawater
Here in the Virgin Islands, much of our personal water consumption comes via rainfall we capture from our roofs into our cisterns (big underground swimming pools). Even with that I still need to truck in water a few times a year when the rain hasn’t been sufficient.

My roof surface area to consumption ratio is such that this system works pretty well for me (big roof, small human). However with a farm the roof surface area to consumption ratio is flipped - big fields needing water and little to no roof (maybe a tool shed or garage). And you can’t increase roof surface area since that would block sun from the plants. Industrial uses also have a poor ratio. Dense usage of water in a limited size building.

JacobDotVI··on Shopify and the Power of Platforms
This isn't necessarily a fair comparison - card not present transactions have always had a much higher rate than point of sale transactions due to the increased risk of fraud. There's an open-ended question of if new entrants like Apple Pay can bring down those card not present fees thanks to their integration into your apple id, but tbd.
JacobDotVI··on New Hampshire installs historical marker to honor the creation of BASIC
Could be - but they definitely had a location in Manchester as well. I believe they've since moved their HQ to Salt Lake City but still maintain a presence in the city, per their careers site: https://www.pillpack.com/careers/manchester
JacobDotVI··on New Hampshire installs historical marker to honor the creation of BASIC
Dyn (acquired by Oracle), PillPack, Dean Kamen, an Army research lab, and others are all located in Manchester. Considering two of those companies had Billion-dollar exits it seems they are doing something right in NH.
JacobDotVI··on Giving a name to my sales anxiety
This is a fantastic book to read - esp. if you've already read "Getting to Yes" and need a bit of a re-education.
JacobDotVI··on GitHub removes 5 years of One Hour One Life designer's work
I have often purchased dandelion greens at my local farmer’s market - they are great sautéed!
JacobDotVI··on Free Solo and Economic Growth
The author's point about dissemination of information is spot-on.

A couple of years ago, I read Medieval Technology and Social Change, by Lynn White (https://www.amazon.com/Medieval-Technology-Social-Change-Whi...) as recommended by PG. Technically a textbook, it was a dry and drab look at the history of various innovations during Midlevel times - the stirrup, the windmill, etc. The 30,000ft view is that when innovations are introduced it takes a long time both for them to spread and for someone to finally exploit them to their greatest contributive state. While the steam engine was not invented until 1712, all of the components had been available since Roman times. It took quite a long time to find one of the greatest uses of those innovations. At least, it used to take a long time -

Now, information and innovation spread much faster. Society moves much faster. The innovation of the stirrup took a thousands years to propagate. The innovation of the internet took less than 50 years; Smartphones took 5. The pace of global change is increasing exponentially. A modern entrepreneur must have line of sight to the latest innovations in order to anticipate their impact on his or her society, industry, business, and personal well being. No one wanted to be the new Nokia, Borders Books, or Woolworths.

But, let's take a step back from specific innovations, and look at global mega-shifts in society. From the agricultural revolution, to the various metal ages, through the industrial revolution we are now being lapped by the waves of the Information Age.

As humans we quickly absorb each individual change brought forth in the information age - email, cellular connections, the world wide web, the smart phone, etc. Can you imagine running your business without your iPhone? We very quickly adapt to the here and now and forget the way it was (Thank you evolution!). However, what we are not good at perceiving is the systematic, second-order changes that the Information Age will bring. The Agricultural Age brought these changes over thousands of years. The Industrial Age brought them over generations. The Information Age will bring them with alarming speed that we may not be prepared for:

* Retailer's monopoly on local distribution was destroyed by Amazon.com + UPS

* Newspapers have been shattered by the internet's ability to breakdown their stranglehold on the distribution of information.

* The telecom world was turned upside down by the introduction of the cell phones, the internet, and the disruption of their monopoly on land-lines (Note that AT&T is a mere brand name, which was purchased on the cheap by SBC).

* The traditional media world felt this shock earlier this year when a man with a twitter account was able to upend their distribution monopoly on the news and they were left reacting and pandering instead of dictating.

But these are a number of examples in the commercial world. What about society itself? What about the global financial systems? What about governments?

Note: this was part of a letter I sent out with a Christmas gift a few years ago. Full letter here: https://blog.jacob.vi/the-sovereign-individual/

JacobDotVI··on Full Disk Images of Earth from GOES-17
Most US Government produced works are public domain.

https://www.ospo.noaa.gov/Organization/About/use.html

JacobDotVI··on IBM halting sales of Watson AI tool for drug discovery
There was even an Artificial Intelligence in Medicine Symposium held in 1979 -

https://blog.jacob.vi/an-80s-throwback-artificial-intelligen...

In response to the above blog - Watson's early small-scale success clearly hasn't scaled to bigger and broader applications.

JacobDotVI··on The Notre Dame fire and the future of history
Microsoft had a pretty impressive demo of a 3D recreation of Notre Dame using photos scrapped from Flickr back in 2007:

https://www.ted.com/talks/blaise_aguera_y_arcas_demos_photos...

I believe they used to have a viewer for the model available on the web, but I can't seem to find it at the moment (maybe it died when Microsoft killed their PhotoSynth product).

JacobDotVI··on Amazon's empire rests on its low-key approach to AI
GMV is Gross Merchandise Value, not stock price.

https://en.wikipedia.org/wiki/Gross_merchandise_volume

eBay states there's here: https://ebayadvertising.com

The question is what is the GMV for Amazon's entire marketplace vs. their first-party Sales.

JacobDotVI··on VS Code on a Remote Server
Potentially but not necessarily. Two thoughts:

1) I may not need to see the data itself during most (or all) of my dev loop, but just see any errors that are thrown.

2) Taken as risk mitigation, data temporarily cached in your browser is less risk than data permanently stored on your laptop, esp. when the threat you are mitigating is lost / stolen laptop.

JacobDotVI··on VS Code on a Remote Server
HIPAA - I want to be able to build data pipelines against patient data without the data itself leaving the server. Having my dev loop live on the same server as sample data is better than working against fake or synthetic data locally
JacobDotVI··on Delta Debuts World's Largest Jet Engine Test Room
United Technologies once owned United Airlines in a vertical play, before anti-trust pressure led them to split up:

>The origin of UTC lies with the company formed in 1928 by William E. Boeing as Boeing Airplane & Transport Corporation, which held controlling interests in Boeing Airplane Company, Boeing Air Transport Inc., and Pacific Air Transport (see Boeing Company). Within a year the company was renamed United Aircraft and Transport Corporation and acquired a number of aircraft- and aircraft-component-manufacturing companies including Sikorsky Aviation, Stearman Aircraft, Avion (later Northrop Aircraft), Chance Vought (aircraft), Hamilton (propellers and aircraft), and Pratt & Whitney (engines). In another two years it consolidated four smaller airlines into United Airlines and made it a subsidiary. In response to legislation prohibiting the affiliation of airlines with aviation manufacturers, United Aircraft and Transport Corporation was dissolved in 1934, resulting in three separate companies. Manufacturing facilities west of the Mississippi River became Boeing Airplane Company, those east of it became United Aircraft Corporation, and all transportation services were unified as United Airlines. United Aircraft Corporation retained, among other companies, Pratt & Whitney, Sikorsky, Hamilton Standard (later Hamilton Sundstrand), and Chance Vought. The first three companies remained core units of United Aircraft and then UTC until the early 21st century.

from: https://www.britannica.com/topic/United-Technologies-Corpora...

JacobDotVI··on Space Colony Art from the 1970s
This is awesome! I did a similar thing a couple of years ago for framed prints of space:

http://omgspaceisawesome.com

JacobDotVI··on Big List of Naughty Strings
Often times instead of the list of US Sates, you actually want to list of US States and Territories:

https://en.wikipedia.org/wiki/List_of_states_and_territories...

For example when the intent is "list of place where the USPS ships" or "list of state-level political jurisdictions where US residents live"

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