1,331 karma · joined July 31, 2014
2. Because their base metabolic rate reduces over time to match their new reduced caloric intake.
Also would encourage you to read up on recent literature about fats. The "low fat = healthy" fad hasn't held up for some time.
https://www.sciencedirect.com/science/article/pii/S073510972...
> The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite mounting evidence to the contrary. Most recent meta-analyses of randomized trials and observational studies found no beneficial effects of reducing SFA intake on cardiovascular disease (CVD) and total mortality, and instead found protective effects against stroke.
Not even sure how to respond to that one. American diabetes rates?
> Primates have a hard time producing fat from carbs
??? carbs -> glucose -> insulin -> increased lipogenesis. Carbs are _better_ than protein or fat at producing bodyfat.
> Is eating lots of animal products bad for you? Yes. It's been shown again and again in large studies that humans do better on predominantly whole plant foods.
In large, observational studies with innumerable co-founding factors, including lumping regular meat (a steak) in with highly processed meat (mcdonalds burger).
I agree with the whole food part, and plants can be good, but exclusion of unprocessed meat is not proven to be any more healthy.
You also self describe as vegetarian in your profile, and ketogenic diets often include meat.
> Conclusions: The KD is a safe and efficacious therapy for intractable childhood epilepsy in Chinese children. The influence of age on efficacy is worth further investigation.
?
Study 1 doesn't actually show increases in kidney stones.
Study 2 has N of 4...
Study 3 looks reasonable, though they did note "use of oral potassium citrate significantly decreased the prevalence of stones" which is good news!
Study 4 has N of 25 & no info about what they actually ate other than macronutrient ratio.
The point is people who are overweight tend to lose weight when eating ad libitum on a ketogenic diet, whereas people on a standard diet generally gain weight (see western populations).
> FUTON bias (acronym for "full text on the Net")[1] is a tendency of scholars to cite academic journals with open access—that is, journals that make their full text available on the Internet without charge—in preference to toll-access publications.
This case of "one in a million" does not happen frequently.
> Banting was no expert in the field of carbohydrate metabolism, so when he requested laboratory space and facilities from Professor John James Rickard Macleod, Head of Physiology at the University of Toronto, the esteemed physiologist was at first reluctant.
> However, Banting’s persistence and the possibility of more reliable results persuaded MacLeod to donate laboratory space. While tying up the pancreas to make it break down was not a new investigative tool, the idea of isolating islets due to their slower degeneration was of keen interest to Macleod.
https://www.medicalnewstoday.com/articles/323774#development
For any reasonable definition of "safer", yes. 100% safe? no.
https://pubmed.ncbi.nlm.nih.gov/30611908/
> In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.
https://www.mayoclinicproceedings.org/article/S0025-6196(15)...
> The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses of vitamin D (usually in the range of>50,000-100,000 IU/d for months to years).
You can find more sources by scrolling down to the "summary" section, https://www.foundmyfitness.com/episodes/jre-1474
I've seen multiple sources say that 1000 IU of vit D is usually insufficient to boost levels, with suggestions of up to 5000 a day. My mothers doctor put her up to 2000 a day because 1000 did nothing to her levels, which were already low.
After there is the big engines, Unity, Unreal, and Godot. They all have their ups and downs, but are the next level of complexity up from the previously mentioned tools.
If you're into specific niches there are sometimes purpose built engines for it, like RPG Maker. They are usually much less complex, albeit limited to specific kinds of games.
This is the default mechanism for electron apps to auto update, and I haven't heard any issues from it to do with rate limiting.