adamzk

Is this a joke? Whenever I press the button it skips to the next video instead of preventing it from switching. So the ones I want to see are immediately stopped. It's quite frustrating but I guess that's the point?

As mentioned in the article they are very effective at preventing smaller companies from producing generic versions based on expired patents. Then they just stop manufacturing the old drugs so there is no supply.

I think too much focus on the trees. To get to a trillion we need 125 trees per person on the planet. Removing those who are not in an area where tree planting is possible and cannot viably get to one, those who don't care, and those who simply cannot (children, disabled, etc) we are probably looking at tens of thousands of trees per person. I think at that point a tiered leaderboard would be more effective. Naming and photographing 10,000 trees is going to get old fast but getting to Forest Ninja level before your friends has some appeal to it.

Also there needs to be some system of logging (lol) which areas are ok to plant (avoid messing with earth's albedo, fire prone areas, for example) and among those which have not yet been planted. This will require and a way for users to check off what they've already covered and a collaboration with some organization who can say which areas are ok to plant and what types of trees will grow well there)

Furthermore there's needs to be an instructional aspect as to how to properly plant trees (seeds are a bad idea because they require regular follow up until they have sprouted). Saplings are a better bet which will require a list of places to get sapplings.

Ideally saplings will be free for users which will require coordination with governing bodies in every country that participates in order to subsidize the cost either at an individual level or directly to the suppliers. Either that or some kind of ad-incentive program for suppliers who are willing to donate.

It would be ideal if the suppliers rented tools as well and provided top soil and Schultz (growth mix).

This stuff has to come from somewhere. Either private equity or big brother. Should ask MacKenzie Bezos. She'd be down. Bono would be all over it. Bill and Melinda too. Maybe a live8 style benefit concert or something. Orr.. here we go, let people who can't go out and plant pay for the supplies for other people to do so. So you can have points for paying for trees. Points for planting them and triple bonus for doing both yourself because that's just awesome.

Or a mix of all the above. Pool the funds and then allocate them to suppliers when users indicate that they want to go to that location and get started. Really well suited for management by an app.

The app should also facilitate group efforts like matching groups of people in the same area with a nearby planting zone so they can rent a bus for a saturday and make a trip to somewhere a little less local.

I'm trying to think of ways to make this as frictionless as possible. Like i have an afternoon to kill and maybe some friends who would be down so I open the app. I need a map with available planting areas nearby and also sources for saplings. Do I have a car? A car with lots of space? Just a bike? Can I afford to fund this myself right now? Based on this are there any opportunities nearby? Maybe a notification based on those criteria if my location changes? Like maybe I'm on vacation and I need something to do or I'm driving somewhere and could stop for half an hour if the stars align.

Except sand is silicon not carbon

Yes but they all require a ~1bn dollar investment by somebody. Let's not forget the price alphabet is paying for this. And they have already agreed that they would not have IP level access to any of the data collected. Nothing personally identifiable. And all data goes through a 3rd party committee over which they have no control. I'm not sure what would lead somebody to vandalize the sensors besides ignorance and paranoia. What people fail to realize is that mass data collection, when done right, can be an extremely useful tool in improving convenience and efficiency of service. While alphabet may have a dodgy history of collecting information they had no right to, they are not Facebook or Equifax. As far as I am aware they havent mishandled or abused the data they've collected and it genuinely seems like they are committed to honest data collection this time around. Honestly I'm more concerned that the privacy committee that Toronto puts together will botch the data collection/storage end up leaking the data. And most likely they will blame alphabet for it in an "see we knew this would happen" kind of way. I lived in Toronto for a decade. Maybe it's because of Rob Ford but I have zero faith in the competence of Toronto city politics and fully expect them to over involve themselves beyond their capacity and royally fuck things up and then shift the blame to somebody else. #blockthesidewalk really says it all.

I would go further and lower the voting age to 16 and not let anybody over 60 vote. Call it undemocratic, call it a violation of rights but theyre not going to be here when shit hits the fan and they're going to vote accordingly and in doing so they will prevent anybody under 18 from making it to their age on a planet that anywhere near resembles the one they have devoured. That's an even more egregious violation of rights but nobody talks about it because there can be no accountability. Like putting a bag a flaming shit on somebody's doorstep and then running. Rather keep the shit where it is now then step in it later, thank you.

This is an ad for VW

Well that seems perfectly reasonable to me. Read the terms of service or ask important questions when you before you start paying them once a month like "what happens if I don't use all my minutes?" (They rollover) "Do I have to keep paying if I have minutes already?" (No) "are the minutes refundable?" (No). You can't just walk into a store and say "talky talky please" and walk out with a phone. Allowing her to use the minutes toward internet and TV is generous of them.

Just because ADHD is poorly understood and often diagnosed incorrectly does not make it any less debilitating to those who have it and certainly does not imply that they are not in need of medication. Yes the medication can be abused by those who don't need it to get an edge. This is what makes it a controlled substance. Opiates can be abused too and have the same effect on everybody. The difference is that people in server pain need opiates to function at a baseline normal level. People with ADHD need medication to function at a baseline normal level. The fact that some people abuse them to go beyond that is completely irrelevant

The papers going back that far are to determine which synthetic steps are experimentally viable. You can look at a molecule and think how could I make this? Well if I broke this particular bond it would make A and B, which I can order from a supplier. So let's search the literature to see if anybody has successfully carried out a reaction that connects an A-like molecule and a B-like molecule in a way that would yield the kind of bond(s) that connect them in our target. That's a lot of searching because for a typical drug, there are 10s to 100s of bonds and a total synthesis can take upwards of 20-30 steps. Thankfully, making and breaking most of the bonds is just not possible given the fundamental nature of the compounds (more specifically, it would take a ton of energy to put the molecule together this way, and if that much energy was applied, it would react at more reactive sites long before the desired reactivity occured). For others it is less clear, which is why having a comprehensive literature sure is useful. If your database goes all the way back to the 1800s you can say with some confidence that a certain step has never been done before and therefore assume its not possible (perhaps an incorrect assumption, but pharma isn't interested in developing novel types of reaction methodology for a target screen because if it hasn't been done already, it would probably take several years and the chance of success is low. And besides, that's what graduate students are for ;)

So the literature search is to find out what's possible. Among the possibilités, the only ones of interest are those that are not covered in patents, hence the second screen.

I'm a patent holder for a pharmaceutically relevant class of compounds. There are two types of patents typically seen in pharma. One is procedural (how the drug is synthesized, isolated, formulated or administered) and another is composition of matter (the atoms in the molecule, their relative coordinates and the lengths and types of bonds that connect them). This program takes a target compound and does two things. 1) produces a library of similar compounds by structural diversification (making substitutions of atoms or small groups of atoms in the target compound with other atoms or groups which are known to behave similarly) with restrictions based on what has been patented under composition of matter. 2) It then takes each molecule and looks for ways it can be synthesized. It does this by breaking apart the molecule piece by piece until it obtains commercially available building blocks. These piecewise separations correspond to synthetic a steps in the other direction, which the program screens for literature precedence. It does this for every possible combination of piecewise separations until it finds a set of viable pathways from available compounds to the target. This is called retro synthesis. It then filters the potential synthetic routes for those that are covered by procedural patents until it has a list of non patented, commercially viable synthesis plans.

As you can imagine there are thousands of ways a moderately complex molecule could be deconstructed and the bank of known reactions is more than any one person can really grasp. That and the myriad patent literature and how cryptic and dense it can be make the problem particularly suited for algorithmic treatment. This is only being done now because cataloging all the research and patent literature (which goes back to the late 1800s) and digitally formatting in a way that allows it to be computationally analyzed and processed requires manual translation of each report by a human being. Not many people have the expertise required for this and those that do usually prefer less menial work. So it has taken this long to amass a digital library of sufficient size to give one confidence that the answers it provides are comprehensive and that further searching would be pointless.

I got a memory foam mattress from Costco for under 200 delivered and I was quite satisfied. It also rolls up to about 2ft diameter.

I think there's a crucial difference between legitimate open campaigning and deceitful clandestine campaigning. The former is an investment toward making certain facts and, possibly controversial, opinions made known to a wider, perhaps targeted, audience and the ultimate motivation for this is transparent. The latter is a deliberate attempt to sow disinformation and confusion to particularly vulnerable audiences to achieve an outcome for which the ultimate motivation is troublingly obscure. They are total opposites - truth and lies.

How do you vote somebody out?

Well theres nothing in the article that falsifies that statement.

Anybody who has hunted for an apartment semi regularly over the last few years can verify. The first obvious trend is that Airbnb prices have skyrocketed since 2016 due to a positive feedback loop of "well if she can charge _that_ much for _that_ place, I could charge more for mine". Perhaps less obvious is the disappearance of monthly rentals from the market as landlords switch to airbnb. Two years ago on sites like padmapper most listings were for monthly and yearly rentals with the odd airbnb listing. Now it's the reverse.

Dead people don't give testimonies.

Yeah but he did it to get the job not to defraud anyone. That's dedication not deceit. He wasn't pretending to be anybody else. He was probably rejected from a million jobs before this one despite presumably being extremely well prepared and qualified. So other options are there? Fudge the references, perform well and ask for forgiveness later. I say hire him. Not everybody has the luxury of a fancy education and the connections that come with it. Not everybody comes from an environment where they have the privilege of interaction with others in the field. Some of us come from nothing and educate ourselves independently. It's a shame that its nearly impossible to get one's foot in the door despite having ostensibly worked harder than many of those who were given a fair shot. Check your privilege.

If the formula ingredients are so cheap why not just buy each of the components in bulk and mix your own? The components are all listed on the packaging and can't be that difficult to obtain in bulk and good quality. The relative quantities I'm sure are proprietary but could easily be estimated from information available in pediatric nutritional literature (maybe paywalled but worth the investment).

I've also heard a convincing argument that there's an evolutionary response to prolonged hunger akin to fight or flight response that enhances cognition to better enable us to find food.

1) it's all in the terms of service. Idk why anybody is surprised. They own everything you enter into the app anywhere full stop.

2) it's not going anywhere. Its the gay Facebook. It has monopolized the market of an already vulnerable demographic so they can do whatever they want and still charge an extraordinary amount (almost $20 per month??) and provide no customer service.

The app doesn't even function as advertised (at least on Android). Push notifications and read receipts have been broken for years. Btw if you restrict the permissions of the app they permanently change your status to offline.

Because they trojan horse'd it in with the Facebook scandal.

I think depending on the size and shape of the region of constructive interference it's possible to apply force selectively to somebody's head. In my old apartment, one of the cabinet doors in the kitchen would rattle when the music in the living room played a certain note. Putting my hand in that area I could feel the force of it and it had fairly discreet boundaries in all 3 dimensions. I can imagine it would cause quite a headache if that were suddenly applied directly to my brain. And that's just from my stereo. Work a moving source with broader range, it's theoretically possible to"sweep" an area for susceptible targets. When the source is outside the audible range it would could be largely unnoticeable. Selectively applying pressure to certain parts of the brain can cause a range of symptoms. Like if all of a sudden somebody squeezed your pituitary gland how would you feel?

Gingerbread. Houses.

Not just BTC. iota, which is supposedly scalable, has come to a screeching halt over the last few days as well