Hacker News Reader

alfonon 15-minute at-home Lyme disease tick test

You're the smart one.. Unfortunately I didn't find the tick on time and have been sick with persistent Lyme for over 10 years. Hoping for some kind of solution soon.

alfonon Palantir and other tech companies are stocking offices with tobacco products

Not much different than a fully stocked fridge with alcoholic beverages. Consume responsibly, we're all adults.

alfonon Slop Detective – Fight the Slop Syndicate

But then it wouldn't classify as slop?

alfonon 12ft.io Taken Down

https://github.com/wasi-master/13ft

alfonon A Single Div

The "about" page is a comment in the HTML source:

> This is a CSS drawing experiment to see what's possible with a single div. To learn more about this project: GitHub: https://github.com/lynnandtonic/a-single-div Mozilla Hacks: https://hacks.mozilla.org/2014/09/single-div-drawings-with-c... Talk from CSSDay: https://lynnandtonic.com/thoughts/entries/talk-illustration-... Codepen: https://codepen.io/lynnandtonic Mastodon: @lynnandtonic@front-end.social Twitter: @lynnandtonic

alfonon Adult Attention-Deficit/Hyperactivity Disorder and the Risk of Dementia

I have a brain disease driven by an infection that gets better with long term antibiotics.

One of my main symptoms was MCI. Interesting that after long term treatment not only the MCI improved or subsided but also my very long standing ADHD (present for as long as I can remember) got dramatically better, makes you wonder.

alfonon Hackers can use credit bureaus to dox nearly anyone in America

Would a credit freeze prevent data brokers also accessing the credit header?

alfonon Ask HN: I'm 40 and feel my mental ability declining. Programming seems harder.

For someone who has been forced to try countless substances / diet regimens / health strategies due to a pervasive chronic disease, I beg to differ. There's so many things that you can personally do that will alter your cognitive abilities, sometimes to an incredible extent. The tricky bit is that there is indeed no silver bullet, and what works for someone might do nothing or create harm for another. So in my opinion, understanding that there are alternatives to resignation is really the critical component.

alfonon Vitamin D supplementation worsens Alzheimer's progression

Try assessing your Plasmalogen levels.

https://prodrome.com/blood-test/

Hearing very interesting (yet unpublished) results coming out of Dayan Goodenowe's trials of supplementing Plasmalogen precursors on Alzheimer patients. A lot of folks over at APoE4.info have been on the precursors for many months.

https://www.youtube.com/watch?v=mf1Q00QByIA

alfonon Killbutmakeitlooklikeanaccident.sh

Seems it wasn’t just “possession of an oil filter silencer”:

> Candelario sold and manufactured AR-15 style assault rifles in Maryland without a license. The ATF caught Candelario by using an anonymous man to purchase the firearms in a gas station parking lot. This agent purchased six rifles, as well as two fuel filter silencers.

alfonon Missing link between Alzheimer’s and vascular disease found?

With respect to Dayan Goodenowe and his Plasmalogen theory, I think the Rush study should be reproduced by other groups. I am no qualified to judge it either, but thinking critically, unless some glaring statistical mistakes were made, or error measuring the levels, or simply that plasmalogen deficiency is a biomarker more than causative (he goes at length as to why he considers it to be the latter), we are talking about natural compounds (Plasmalogen precursors, or IV plasmalogens) that do not require FDA approval, so it should be fairly straightforward to fund, develop and test.

“The clinical implications of this study are obvious. This is the first reported evidence of a metabolic phenotype with the same clinical characteristics as the APOE ε2ε3 genotype. The probability of dementia in participants with either a high PBV or an APOE ε2ε3 genotype was indistinguishable”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523320/

alfonon Missing link between Alzheimer’s and vascular disease found?

I recommend to take a look at this interview by the very Bredesen, to a scientist called Dayan Goodenowe, working also on the Alzheimer problem. He has a very interesting book called "Breaking Alzheimer" that postulates that DHA Plasmalogen deficiency is causative for Alzheimer. Very interesting stuff:

https://www.apollohealthco.com/facebook-live-plasmalogens-an...

alfonon An ALS Protein, Revealed

Was reading this article and this comment came to my mind.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4832962/

"Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body."

alfonon An ALS Protein, Revealed

Depends on the antibiotic. I believe their molecular mass has to be lower than around 500 Da for them to reliably cross the blood brain barrier. It also depend whether meningeal inflammation is present or not

alfonon An ALS Protein, Revealed

"Ticks love to be in moist, low grass, so a lot of games, whether it's football, baseball, tend to happen in the morning. There may be dew on the grass and that's where a lot of ticks survive and hang out," Nesheiwat said.

https://www.cbsnews.com/newyork/news/ticks-lyme-disease-cdc-...

Lots of anecdotal evidence of ALS developing after tick bites, or more concretely infection with Borrelia Burgdorferi.

Probably a genetic component, and other enviromental factors are also involved, but the only dramatic reversals of MND I have seen documented (or heard about) have been either with IV antibiotics [1][3], or years of Mercury chelation [2]

[1] https://invisibledisabilities.org/award-recipients/2011award...

[3] https://pubmed.ncbi.nlm.nih.gov/17212618/

[2] https://www.researchgate.net/publication/317849075_Healing_o...

In the recent book "Chronic" by Dr. Stephen Philips, he's frustrated since he can only treat successfully (outcome similar to Dr. Martz), with antibiotics, about 15% of his ALS-like patients. Considering how uniformly fatal ALS diagnosis is otherwise, even considering how skewed of a sample he might get (patients that already know they are Lyme positive or suspect it), still find it astonishing.

alfonon An ALS Protein, Revealed

https://www.youtube.com/watch?v=UY9FdULDV6M

https://www.lymeneteurope.org/forum/viewtopic.php?t=3647&fbc...

Who knows..

alfonon Show HN: Looptap – A minimal game to waste your time

Thanks for the note!

alfonon Show HN: Looptap – A minimal game to waste your time

You beat me to it, haha, This is what I just did:

function intersectRect(rectA, rectB) { return !( rectB.left >= rectA.right || rectB.right <= rectA.left || rectB.top >= rectA.bottom || rectB.bottom <= rectA.top ); }

const arc = document.getElementById("arc"); const ball = document.getElementById("ball");

setInterval(() => { if (intersectRect(arc.getBoundingClientRect(), ball.getBoundingClientRect())) { window.dispatchEvent(new KeyboardEvent('keypress', { keyCode: 32, })); } }, 10);

My code seems to go on forever, closed the tab after it reached 60K

alfonon Lab Leak 2.0?

Note that the author does not imply that Delta originated from a lab, but rather that Delta leaked from a lab at the end of 2021, and cites a supporting source.

alfonon Drug treatment for Lyme disease could lead to its eradication

My question would be how easy is for this molecule to cross the blood brain barrier. Perhaps if toxicity is very low you can diffuse it somewhat by maintaining high levels in blood, but my understanding is that molecules with a weight of more than 400daltons have trouble crossing it.

It might be also true that a certain percentage of lyme patients have some level of meningeal inflammation that might facilitate crossing more.

alfonon A shot to prevent Lyme disease could be on its way

Thanks for that link, super interesting.

Check out also Dualdur, received 3MEur from EU in 2018.

https://lymediagnostics.com/why-dd/

alfonon A shot to prevent Lyme disease could be on its way

Any reason why this injection of OspA Monoclonal Antibodies wouldn't help in late disseminated Lyme disease?.

My understanding is that very tough cases of neurological Lyme disease often benefit greatly from IVIG. Wouldn't this be a more targeted version of IVIG?

alfonon Alzheimer’s enigma: Why is incidence falling 16% a decade in richest countries?

Indeed, every measure that helps decreasing the overall heavy metal burden is welcomed.

One of such is the Minamata convention on Mercury [1].

"Studies also confirmed that neurotoxic metals, including lead, mercury, aluminum, and manganese, are measurably more harmful in combination than separately" [2]

One researcher that has been advocating for the link between mercury toxicity and Alzheimer's is Dr. Boyd Haley [3].

Lastly, here is a cool video showing how Mercury causes neuron degeneration: https://www.youtube.com/watch?v=bpC17nfZVvU

[1] https://en.wikipedia.org/wiki/Minamata_Convention_on_Mercury

[2] DOI:10.1588/medver.2005.02.00070 [3] https://www.youtube.com/watch?v=8AQxkIcXrt0 [4]

alfonon Complexities of e-mail validation logic

Or use a password manager.

alfonon Select a muscle and it provides the exercises to workout the selected muscle

I hear you on this problem. You might consider checking out the articles and videos from https://mskneurology.com/. It's a superb resource.

alfonon Chrome Is Bad

Here you have another one: ilovechrome.com :)

alfonon Poll: Will you take the Covid vaccine?

What if every young person with no risk factors (that might be those more likely to be out and about spreading the virus) thought like that?. It sounds kind of selfish to encourage others to be your guinea pigs “so they can protect their parents”

alfonon No one who got Moderna's vaccine in trial developed severe Covid-19

Not everyone has the privilege of working from home while they get their meal preps comfortably delivered to their doorstep.

alfonon Hands-Free Coding: How I develop software using dictation and eye-tracking

I recommend having a read at this: https://mskneurology.com/how-truly-treat-thoracic-outlet-syn...

alfonon Ask HN: What are your go to SaaS products for startups/MVPs?

https://www.revenuecat.com (YC S18)

API to manage In app subscriptions. I think it qualifies since it’s free up to 10K$ MTR.

Disclaimer: I work at RevenueCat, not in the mobile side of things although if I were to start a mobile app with subscriptions, after seeing how painful is to get it right, I for sure would use them.