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ampdepolymerase

1,535 karma · joined January 31, 2020

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ampdepolymerase··on Help users in Iran reconnect to Signal
It is not. Healthcare and communications are very much comparable if your life and livelihood are on the line. If the downside risk for both is a dead person then they are very much morally equivalent.
ampdepolymerase··on India proposes law to ban cryptocurrencies, create official digital currency
How fast is clearing and settlement in traditional Indian banking?
ampdepolymerase··on How a Cancer Drug Carrier's Structure Can Help Selectively Target Cancer Cells
1) This is not a therapy. This is basic research that could potentially lead to a therapy, or it could merely lead to a marginal improvement. Most of science are like this, massive Deep Learning style leaps are relatively uncommon.

2) The research is about a group of chemical structures called Porphyrins, commonly found as part of a human proteins. They are apparently a good fit as delivery vehicles to send anti cancer drugs into cells. Apparently these particular chemical structures have inherent anti-cancer properties too. This is a very simplified explanation and I have not read the paper itself. This is a chemistry/biochemistry paper as much as it is a biology paper.

3) It is very difficult to explain to a layman whether a research is truly useful, or whether it will end up as a dependency (to use a software engineering term) of a bigger research. Imagine somebody made a marginal improvement to a neural network model. By itself it is not revolutionary, but the incremental gains add up over time. This is an incremental gain, a lot more work and research will be needed to turn it into a possible therapy. And even then it may hit some snag down the road that will render it useless. Science is tedious and expensive.

ampdepolymerase··on Disorderfs: FUSE-based filesystem that introduces non-determinism into metadata
It's a form of fuzzing. A bug free build system would not be affected by non-determinism.
ampdepolymerase··on Parents' income, not smarts, key to entrepreneurship
I was referring to the fact that Zuckerberg success was possible because of his background (his parents were both professionals, one was psychiatrist, the other a dentist), and not necessarily because of good grades. Plenty of people get good grades.
ampdepolymerase··on Robinhood now has a 1-Star rating on the Google Play Store
A better way would be to update the definition of a public square to take into account the exponential scaling offered by digital services. Communication and commerce infrastructure should not be allowed to censor the moment they cross a critical point in scale.
ampdepolymerase··on Parents' income, not smarts, key to entrepreneurship
Are you aware of how much Phillip Exeter costs?
ampdepolymerase··on Vue Native (2018)
You might not like Svelte.
ampdepolymerase··on Let's Not Dumb Down the History of Computer Science (2014)
Well, most students in (contemporary) math programs don't learn to derive their axioms from Euclid (construction of naturals are usually done via Peano), their Calculus from Newton's Principia, and nor do they learn their set theory from Cantor's original papers. Instead they learn from modern textbooks that make only a passing reference to the original authors.
ampdepolymerase··on Let's Not Dumb Down the History of Computer Science (2014)
Because a lot of CS history are only relevant in a larger/humanities context. In terms of absolute technical value, the historical contributions are not necessarily as valuable. Russell and Whitehead's Principia Mathematica has next to no practical use in modern day software engineering. Their existence helped induce Church and Turing to create modern computer science theory but the discrete mathematics in that book itself holds little value for your average computer scientist outside of being an intellectual exercise.

Another issue is that CS is a branch of applied math that also happens to be extremely profitable. Math operates on much larger timescales than other domains. But business and economics demands immediate attribution. McCulloch and Pitts had their Hebbian neural network almost a century ago. Kleene of the Regex fame designed his neural network in 1951 [0]. These vast timescales are quite normal for advanced mathematics. But in 2010 GPUs became cheap and the obscure theories of the pre-GOFAI age are suddenly immensely profitable. Of course the names and associations would be with their most recent implementors. The ones who actually applied and made it possible, rather than those whom dreamt it up a century ago.

[0] https://news.ycombinator.com/item?id=25882079

ampdepolymerase··on Frugal Web Browser: A Design Experiment
I want the exact opposite. All the current efforts in amateur browser building are all focused on documents. Gemini, and HN's other perennial favorite, Gopher, all look several decades out of date. I want a clean slate platform that is focused on high performance, superb design, and great developer productivity with an emphasis on 2021 hardware. A clean slate redesign of HTML with WebAssembly GUI widgets as a first class citizen (instead of the current "draw-to-canvas" hack). Gemini and Gopher will never gain traction if they perpetually look anachronistic. Forget about stuff like the semantic web. Those are dead ideas that will never take off unless they are properly backed by a strong business model. When I look at Gemini and the various new browser experiments, I get the feeling that HN web engineers lost their way. I know this forum worships Alan Kay and Brett Victor, but if all the new web browser projects here focus on the "good ole days" where everything is a semantically linked document, then there is no more room for growth. Where's the emphasis on UI and UX? Users clearly want apps that run fast and look pretty. For some reason engineers here reject that proposition and prefers ugly looking documents in the name of simplicity. Compiler and language technologies have advanced leaps and bounds since the Netscape days. We have .NET, LLVM, GraalVM, Julia, and two dozen different high speed production ready WebAssembly interpreters. 16+ cores hardware is starting to become the norm. Yet everybody is obsessed with the concept of a boring Tim Berners-Lee era document. Dream bigger. Figure out how to get native level performance on mobile devices if you are building a "web" browser. Make creating responsive GUIs as easy as traditional absolute positioned Windows Forms. Design a browser such that making a Stripe-level gorgeous landing pages becomes trival. Integrate Figma as a first class GUI design tool. Make collaboration and CRDTs first class (like the Braid RFC, https://braid.news). Use neural models to speed up content delivery and assets loading. The wave of unimpressive "new" browsers that cropped on HN in the last year reminds me of the Node.js web frameworks hype during the first half of last decade where there was a micro web framework on Show HN every week claiming to be the One Framework to Rule Them All despite mostly being a thin shim on top of express.js/the default node.js APIs and offering no real value. Dream bigger.
ampdepolymerase··on How to create your own country
Here's a more realistic guide with none of the hippie seasteading false optimism:

Step 1) Acquire a large standing army, logistics, and lots of rockets and big radars (the bigger the better, stealth planes are very tricky to detect without massive antennas). Step 2) Nuclear weapons, ICBMs, and stealthy submarines. Step 3) Sufficient infrastructure to support autarchy and the above two steps.

In the current age, without the patronage of a larger state, starting a country ex nihilo with the expectation that it will remain sovereign is not possible (surprisingly you don't hear from Thiel's pet think tanks about the sovereignty problem when it comes to building a country in the middle of the sea, you would think the founder of Palantir should have some creative solutions).

Modern assymetric war doctrine relies on air superiority. Deny other countries the skies and you will be free. You don't really need a conventional navy if you don't plan to project force. Countries like Iran use a large fleet of small boats armed with rockets to counter bigger navies (and more importantly, carriers. Their boat swarm strategy however is untested outside of simulations). A country is built on legitimate violence. At the end of the day, the nuclear triad is the only and ultimate guarantee of true territorial sovereignty. Legitimacy will come naturally when sovereignty becomes absolute.

Sovereignty in political science and international relations lie on a spectrum. Countries like Cuba have quite limited sovereignty[0]. A fully nuclear armed seasteading state may never achieve economic sovereignty due to sanctions by incumbents, but it will definitely have full perpetual control of its territories and in the current multipolar world, there are plenty of opportunities to increase economic sovereignty.

https://www.brookings.edu/research/cuba-the-u-s-and-the-conc...

ampdepolymerase··on American Airlines has so much extra wine that it is starting a delivery service
There are physiological reasons for poorer tasting food and beverages in-flight. Even if the wine is good, the changes in air pressure and environment can affect the taste, a lot.
ampdepolymerase··on Delta Chat – decentralized chat via email
All they need is to rebrand it as an enterprise SaaS and boom, unicorn.

(For those who don't get the joke, see Front: https://news.ycombinator.com/item?id=25272533)

ampdepolymerase··on Racket Compiler and Runtime Status
Congrats on the release. What Racket really needs right now is a proper dependency manager with support for constraint solving and allowing multiple conflicting transitive dependencies. Cargo and yarn are the gold standard for this. A lot of Lisps tend to overly focus on language and compiler features and neglect the more boring tooling and infrastructure that makes a programming language successful.
ampdepolymerase··on ownCloud Infinite Scale: Go instead of PHP, microservices instead of LAMP
There is nothing stopping them from offering a fat binary. Not everything has to run on Kubernetes.
ampdepolymerase··on IPFS Support in Brave
It is not particularly surprising considering that the founder of Brave was fired as Mozilla's CEO and replaced by the current one specifically because of politics.
ampdepolymerase··on Smart Drone Mailbox Secures the Future of “Last Inch” Deliveries
Castle doctrines and make your day laws have to be updated to allow automated defences and booby traps. Right now the classical legal question of securing your mail box against vandalism and theft leaves you vulnerable to civil lawsuit and criminal prosecution. I can see this product finding customers in the Prairies and certain parts of the Midwest. New York and California? A one way trip to jail and bankruptcy.
ampdepolymerase··on Lispsyntax.jl: A Clojure-like Lisp syntax for julia
The irony here is particularly rich considering Julia's parser frontend is written in Scheme.
ampdepolymerase··on Why There Will Never Be Another RedHat: The Economics of Open Source (2014)
They are great because they are the first to prove that it is possible to build a unicorn on purely open source software.
ampdepolymerase··on Ballista: Distributed compute platform implemented in Rust using Apache Arrow
It doesn't.
ampdepolymerase··on Categories of Nets
We may disagree on this point but thanks for taking the time to reply nonetheless :) I will take a look at your paper.
ampdepolymerase··on Ballista: Distributed compute platform implemented in Rust using Apache Arrow
What are some production ready alternatives to gRPC that have both a pleasant developer experience and great performance? Apache Avro? Apache Thrift?
ampdepolymerase··on Categories of Nets
I honestly doubt it will have any practical applications in biology. Computation chemistry and synthetic biology run on differential equations, anything discrete is generally useless. Perhaps it will have some use in a couple of decades when synthetic biology progresses beyond brute force simulations but at the current level it is the wrong abstraction.
ampdepolymerase··on I Tried to Get a ‘Leftover Dose’ of the Vaccine Last Night
Or maybe, the developers need to go back to school to learn about horizontal and auto scaling.
ampdepolymerase··on NSA Recommends How Enterprises Can Securely Adopt Encrypted DNS
It is hard to iterate and make changes when your codebase relies on human/machine assisted proofs. Great for airplanes and cars when regulatory approval means iteration is slow. Not so great for consumer software.
ampdepolymerase··on I Tried to Get a ‘Leftover Dose’ of the Vaccine Last Night
Why are healthcare servers still getting overloaded when HIPAA compliant "infinitely scalable for a price" cloud systems like AWS exist.
ampdepolymerase··on Japanese people may have gained longevity by balancing their diets
If something is truly genetically linked then dieting for you might as well be lipstick on a pig if you don't have the right heritage. There are a couple other places in Asia with similar levels of longevity. Hong Kong, Singapore, and South Korea come to mind. Maybe look into what similarities they share with Japan. For Europe there are the usual Mediterranean countries, including Israel. (For European demographics, remember to adjust for large numbers because population size vary wildly.)
ampdepolymerase··on List of studies showing carcinogenic effects of non-ionizing EMF
Intensity is not the same as energy.
ampdepolymerase··on NSA Recommends How Enterprises Can Securely Adopt Encrypted DNS
Microsoft, and more importantly Microsoft Research, have many, many projects tackling this. Off the top of my head: the P programming language, F*, Dafny, and a bunch of others (I think the last two are part of something called Project Everest). Microsoft Research is one of the biggest players in this field. A lot of their efforts span multiple departments so you will have to search around.
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