boldlybold

Get a browser extension that does it, I finally looked for one after clicking the "not interested" button one too many times.

I find o3 at least faster to get to the response I care about, anecdotally.

That's a new acronym to me, what is it?

Anna's Archive is on the path to this, for written works at least. The main idea is open source code + distributed data in torrents + anonymous contributors that are dedicated to the project.

https://annas-archive.li/blog

Tailscale is great. I put my whole company on it shortly after joining (we had some servers with RDP exposed to the internet...). It has had ~0 problems in the last year, and non-technical people are able to use it with ease.

Pattern Biosciences | Senior Data Engineer (open level) | ONSITE US (South San Francisco)

At Pattern Biosciences (https://patternbio.com), we are creating next-generation cancer therapies at the intersection of synthetic biology and machine learning, with data as the cornerstone of our platform. Our mission is to transform disease treatment, starting with cancer, by leveraging our innovative biomolecular computing technology. By utilizing multi-input, molecular-level computation within individual cells, we aim to deliver curative therapies where the traditional one drug-one target approach has fallen short. Pattern Bio is assembling a world-class team to bring two decades of advancements in DNA computing and machine learning into the clinic.

We're hiring an experienced data engineer to work with the laboratory and computational teams. You'll be a part of a small and dedicated company working to revolutionize cancer treatment with computation in DNA.

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Thanks, was looking for something like this. With all the hardware I'm sure is sitting idle under HN users, we could make a big contribution for ~free.

I was hoping someone would reply with a bash one-liner so I didn't get nerd sniped into doing it myself, thank you

As long as you stay out of the "defaults" and "anaconda" repos, you're not subject to that license. For my needs conda-forge and bioconda have everything. I'm not sure about the nvidia repo but I assume it's similar.

Thanks for releasing this, I've been looking forward to a truly open version I can use in a commercial setting. What a way to launch the company!

I think it's an accurate statement. I've heard similar sentiment from friends in the car with spotify on.

This section of 101 consistently amazes me. It's only rain, and it degrades faster than the highways in the Northeast where I previously lived. Is it a particularly bad recipe of asphalt?

Welcome to the wonderful and confusing world of bioinformatics!

A have a 2007 European car that wants 93 according to the manual, but will "run acceptably" on 91, not sure if it's changed in recent years though.

I contribute to Nextflow core (https://nf-co.re/) It's more of a collection of pipelines than traditional software, but there are users all around the world and a good community.

Most of the packages on bioconda (https://bioconda.github.io/) are open source. But you probably want to find a sub-field that interests you most before finding a project.

In grad school, we also had an ex-google software engineer volunteer with us one day a week. It was very impactful for many members of the lab to learn good engineering practices, and it wasn't at all like the sentiment others in this thread are expressing where engineers were "janitors".

I'm more excited about NVIDIA's acquisition of Parabricks and the version 4.0 of the software that makes it free to use, than I am about DRAGEN. At the very least it's good to have some competition in the space, Illumina's stuff is always SO expensive. We'll have to see what hardware will win in the end.

We're only starting to see the age of genomics accelerated by GPUs. I think it's still early if you have the technical background.

If you have a software background and can get some basic domain knowledge, there's lots of open source projects that could use your contribution.

Doing fundamental reseach is a taller order. But lots of software, tools, pipelines etc need maintainers, optimizations...

As in, the networking equipment consumes the most energy? Given the 30x markup on AWS egress I'm inclined to say it's more about incentives and marketing, but I'd love to learn otherwise.

Lots of places (Hetzner for example) will rent you servers at 10-25% the cost of AWS if you want dedicated hardware, without the ability to autoscale. You can even set up a K8s cluster there if the overhead is worth it.

I had the same problem, the solution is here: https://community.frame.work/t/12th-gen-not-sending-xf86monb...

You can enable the hotkey support by blacklisting the hid-sensor-hub driver: vi /etc/modprobe.d/framework-als-blacklist.conf Add the following: blacklist hid-sensor-hub And then restart

It worked, but it needed `hid_sensor_hub` with underscores! and `sudo update-initramfs -u` before the reboot

Can this plug into an existing USB-C port on the laptop? When I don't need it on the go, that would be easier for docking at my desk.

Low 30s in Palo Alto and Menlo Park where I live. Cold enough to have frost on windshields or grass early in the morning. Biggest change for California weather was the delta between day and night!

This has literally been a bug in google maps for going on 10 years and I'm amazed nothing has been done about it. Terrain could be SO MUCH more useful!

Non-profit institutions with billion-dollar endowments, massive overhead costs, and "tuition" charges that make no sense. I have a really hard time believing this for the larger institutions.

This led to me consulting during my PhD to supplement the stipend up to a reasonable salary. A lot of PhD students, especially if your work touches on computational sciences, are a lot more valuable than the university would like you to believe.

After moving to industry, I'm starting to realize how valuable the consulting experience was. The project management and scoping skills, and wearing multiple hats, were big benefits.

After running ubuntu on a Dell XPS 15 with varying degrees of success the last four years, I placed an order for a Framework laptop that will be shipping this month. I don't expect the build quality to match that of apple, or even dell, but I've read linux support is good, and will only get better with more dedicated people on the platform.

Natural immunity is durable and long-lasting, perhaps moreso than the mRNA vaccines. What's the issue?

Funny how HN is so willing to agree with the absurdity of security theater at airports, yet so resistant to calling out the pandemic theater we're living every day.

It's not for everyone, but only if you want to learn and take matters into your own hands as opposed to simple buy and hold investing. People may recommend not opening a bar for passive income, but it looks like at least someone in here is doing it well.

Of course there's no free lunch or ways to make any considerable profit without risk. But compared to holding long stock, you can take defined risk positions that are more/less risky.