What I'm wondering is why the Kraken2 probabilistic hash table doesn't work. It uses 32 bits per element in an open addressing hash table. For 1 billion k-mers and 19 bits for the value, 32 - 19 = 13 bits of the key hash can be stored alongside the value, helping disambiguate hash collisions. If the load factor is 1.25x, then that's 4 * 10^9 * 1.25 = 5GB total, better than ~7GB. Also, this is only one cache miss (+ linear probing that can be SIMD accelerated) per lookup.