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davecap1on Weak-to-Strong Generalization

There's a lot more to protein sequences than legos. I think the argument is that you don't need to train a model on fundamental organic chemistry/biochemistry, electrostatic protein interaction, hydrogen bonding, hydrophobic interaction, quantum mechanics, etc... in order for it to accurately predict protein sequences.

davecap1on AWS us-east-1 outage

We have federated login with MFA required (which was failing). It just started working again.

Scratch that... console is not loading at all now :)

davecap1on AWS us-east-1 outage

On top of that, the "Personalized Health Dashboard" doesn't work because I can't seem to log in to the console.

davecap1on Launch HN: Seed (YC W21) – A Fully-Managed CI/CD Pipeline for Serverless

How does this compare to something like AWS CodePipeline with CDK (https://docs.aws.amazon.com/cdk/latest/guide/cdk_pipeline.ht...)?

davecap1on This month in 1939: How dead cattle led to the discovery of warfarin

It's been 80 years and we still haven't figured out how to reliably perform loading doses (when someone is just starting out on warfarin) and to maintain stable INR (anticoagulation effectiveness, essentially) in people who take it daily. Lots of work has been done on it, but it is petering out due to the recent introduction of new anticoagulation drugs that do not require regular monitoring.

I happen to take warfarin daily, happy to answer any questions!

davecap1on Invert, always, invert

Interesting way of describing/thinking about hazard or risk analysis which is applied in many industries through ISO standard frameworks such as ISO 14971 for medical devices (but is also used elsewhere). Risk analysis complements requirements analysis in that risk mitigation plans become requirements of the system (if the risks meet some threshold).

davecap1on Local-first software: you own your data, in spite of the cloud

Apple Health and Activity also seem to work this way, although they also sync to iCloud.

davecap1on Decentralized VPN Written in Go

Is this similar to ZeroTier https://www.zerotier.com/?

davecap1on Ask HN: How do you make sure your servers are up as a single founder?

Have you thought about hiring someone remote in the same or different timezone to be on-call for outages? I'm sure there are many people around that would be able to help with this. You could hire someone on a retainer who can be on-call via PagerDuty or something.

davecap1on DNA sequencing progress has stagnated

23andMe only tests for known relatively common mutations (single nucleotide polymorphisms, or SNPs) that have been identified by non-profit large scale sequencing projects done in the past (basically public data now, see dbSNP for instance). You will almost certainly have mutations that are not covered by their panel, so it is not a matter of comparing your 23andMe results to the "baseline" (or "reference genome"). Their panel costs in the hundreds of dollars to run since it is so focused (at least 10x less than a full "exome" test, which would look at the full sequence of all known genes).

davecap1on How to Grow Software Architecture out of Jupyter Notebooks

Is this similar to papermill?

https://github.com/nteract/papermill

davecap1on 11-year-old girl inspired by Flint water crisis creates cheap kit to test lead

If you are in NYC you can test your water for free: http://www1.nyc.gov/nyc-resources/service/1266/request-lead-...

davecap1on What if we made video conferencing work?

There are a bunch of options for low-latency video conferencing solutions available for people who actually need it (tele-medicine/surgery, sports/media broadcasting, enterprise conferencing). The thing is they just cost a lot of money and require dedicated hardware. Here's one company I know of that does this: http://www.haivision.com/

davecap1on Ask HN: What medical datasets do you need?

These are quite difficult to get (and very expensive to produce) even inside the medical-research establishment. Which big players are you referring to?

davecap1on Nylas Mail is now free

There are other mail clients that use tracking pixels, like Polymail and Canary.

davecap1on Mermaid: Generate Diagrams and Flowcharts with Markdown Like Syntax

draw.io is awesome! Thanks for the hard work!

davecap1on AWS CodeBuild – Build and test code with continuous scaling

This sounds a bit like BuildKite which has worked out pretty well for us! They provide an elastic AWS CI environment that you run in your own AWS account, and scales up/down as builds are queued up.

davecap1on Announcing pydoc.io beta

Just FYI `https://pydoc.io/` doesn't load but www.pydoc.io does (at least for me).

davecap1on Ask HN: Do you have a side project you want to sell?

We recently changed the permission to introduce the "pro" blocking feature. There doesn't seem to be a way to get "write" perms in a more granular way. The app doesn't actually post anything though.

davecap1on Ask HN: Do you have a side project you want to sell?

https://www.twitteraudit.com

Estimates fake Twitter followers for any account. Helps users find and block fake followers (coming soon). >100k visitors per month (45% returning). >1M users audited and over 500k users signed-up. Some revenue ($12k/year).

davecap1on Poll on macOS 10.12 is broken

I run linux on the desktop and 1password actually works surprisingly well via Wine. Even the Chrome extension seems to work.

davecap1on Stencila – Spreadsheet-like live reactive programming environment

Off-topic: how do people make those animated gifs like the one in the blog post (https://stenci.la/stencila/blog/introducing-sheets/screencas...)?

davecap1on Ask HN: Who is hiring? (February 2016)

SolveBio | New York City | Full-time (ONSITE)

SolveBio provides a data platform and data science services that can deployed in genomics companies - large pharmaceuticals, R&D labs, molecular diagnostic companies, and health startups. The platform and APIs process and deliver a wide variety of complex biomedical datasets collected from public, private, and commercial sources creating a solid foundation of information necessary to develop more accurate genetic tests for diagnostics and discovery. SolveBio has great backers including Andreessen Horowitz, Max Levchin/HVF, Healthy Ventures, Great Oaks, Red Swan, and others.

We're looking for engineers to further develop our genomic data platform, which includes APIs that feed up-to-date information to customized interfaces, internal data pipeline tools, and secure multi-datacenter deployments. Genetic testing is entirely dependent on reference data and as the industry continues to grow at a rapid pace, SolveBio aims to be a leader in this very exciting space.

Tech stack: Python/Django, JS/AngularJS, ElasticSearch, PostgreSQL, Docker, AWS, Consul, Terraform.

Interested? Email us at: hn@solvebio.com

davecap1on List of high-quality open datasets in public domains

SolveBio (my startup) has parsed, normalized, and indexed a bunch of the datasets listed under biology. Our goal is to make these kinds of datasets easier to access for programmers and non-programmers alike, similar to other some sites mentioned here (Enigma and Quandl) but for genomics. You can query and filter the data on the website or through one of our API clients: https://www.solvebio.com/library

davecap1on How to Fix Everything: Spending a few days at iFixit

You can do that today... it's not the only way but I'd imagine it's pretty common: http://www.apple.com/shop/iphone/iphone-upgrade-program

davecap1on Why Rdio died

If Spotify becomes its own "label" then it'll probably have a better chance... given the size of its user-base.

davecap1on Fame for sale: efficient detection of fake Twitter followers

You can try twitteraudit.com (I made it a few years ago). It doesn't do anything fancy at all, but it works pretty well with about a 10% margin of error. It only looks at a sample of 5000 followers though.

davecap1on IBM's Watson will be used to make decisions about cancer care in 14 hospitals

Cancer is a disease of genetics. You need to know what kind of cancer someone has in order to choose the treatment.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032883/

davecap1on Input, a flexible font for programming

It actually comes with a monospaced variant.

davecap1on When peeing in public in this German city, beware walls that pee back

Listening to Wait Wait... Don't Tell Me?