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davi

3,486 karma · joined April 17, 2008

large scale electron microscopy of brain wiring

https://scholar.google.com/citations?user=UYNRtmkAAAAJ&hl=en&oi=ao

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davi··on Groupon’s Andrew Mason To Charlie Rose: “We Are The ‘N Sync Of Websites”
"So we’ve put all these small kind of niche businesses on the map, whether it’s a — whether it’s a helicopter club that’s offering flying lessons, and we sell 2,500 coupons"

They're talking about Philip Greenspun's [1] encounter with Groupon, about which he says: "I think what this shows is that we were much worse at marketing than even we could have believed." [2]

[1] http://philip.greenspun.com/panda/

[2] http://blogs.law.harvard.edu/philg/2010/03/19/groupon-market...

davi··on Hacker News, now with downvotes
No, the safe move is to assume that pg is doing as good a job as he can to make the rules line up with the collective behavior he wants to see. If you systematically flag every story by an established user whose comment you just downvoted, that would probably trigger a reduction in the weight of your flags. However if you flag lots of spam, and it really is spam, that's good. Please keep doing it.

(And by the way, thank you.)

davi··on Ask HN: Big company looking to acquire us, I'm terrified
Sometimes when something really big and good starts to happen, even if it's something you've been working hard to achieve, it can be a bit hard to understand. Getting used to the idea that yes, you really did it, might be a good step to helping yourself calm down and gracefully surf this newest big wave coming at you.

You worked for it, now nail it!

davi··on U.S. to host World Press Freedom Day
Semantics of "fighting" vs. "supporting" aside, we agree that it's good to give money to organizations that advance freedom of the press.
davi··on U.S. to host World Press Freedom Day
> Be thankful for the freedoms you have and

fight for more. (Or at least donate money to others who will do some fighting for you.)

davi··on "Whale Fail" - Google Books' Error Page
No, there's a third choice. http://news.ycombinator.com/item?id=1777665

[edit: An idea which I wouldn't know about if I hadn't seen it here. For me, HN still is good enough to spend time with. But it has grown less stringent about humor and links to images, which I think reduces S/N.]

davi··on Ask HN: Why aren't scientific journals free on the web?
An answer [1] from a horse's mouth (Floyd Bloom, former editor of Science magazine, originator of the aphorism, "The gain in the brain lies mainly in the stain"[2]):

MI: Was it clear to you when you started out at as Editor-in-Chief of Science how important the move to electronic publishing was going to be?

FB: When I got to Science, it was quickly explained to me that the price for paper was going up. The price for postage was going up, and I was asked where in the budget did I want to make the cuts in order that we wouldn't be in a deficit. And so it occurred to me, if I was constantly going to be confronted by changes in paper costs and postal rates, which I couldn't control, I would have to find another way to distribute the magazine. And we decided we had to be online quickly.

MI: So the age of electronic publishing really came to fruition while you were at Science. Were there issues that you faced for which you really had to define limits as to how far electronic publishing could go?

FB: Well, PubMed Central [the initiative put forth by the National Library of Medicine to archive and disseminate biomedical research findings] was one of the last issues that I faced, and I think, faced down. It was wrong-headed in its origins. But the concept that people should have access to the scientific literature is of course a good one. Scientists want to have access to research findings so that they can pursue experiments. And when scientists are confronted by a publisher's wall that says you must be a subscriber to get in here, you'd like to find a way to get around it.

But to me, nothing is free. I am aware of the cost of making a prestigious publication. The cost of rejecting 95 percent of all the papers that are submitted makes the accepted ones so valuable. And there's only twenty-four hours in a day, no matter how intense your efforts to keep up with research reports. If I have time to read, I'm going to read in a place where I know that the information has been thoroughly vetted, and so I limit my reading to places where I can trust the judgment of the editors. If everything were free, and everybody could publish everything they want to, anyplace, I'd have no way to know how to sort things out. I certainly don't have time to read through a lot of very provocative assertions that turn out not to be true.

[1] excerpt from http://molinterv.aspetjournals.org/content/1/4/192.full [2] Appel 1996 Ann NY Acad Sci "Classical and Contemporary Histochemical Approaches for Evaluating Central Nervous System Microanatomy"

davi··on How to add a notifier LED to your computer
For a long time I've wanted one of these, to serve as an "interruptility" indicator to others: green = "I'm looking at the internet, please interrupt me so I can possibly do something more useful", amber = "I'm working but okay", red = "only interrupt me if it's truly urgent". It could be programmable, so that (for example) it could automatically go to green when Firefox had HN as its frontmost window.

Imagine a lab or office in which everyone used an LED in this way. It might be nice.

davi··on G.E. Goes With What It Knows: Making Stuff
single page: http://www.nytimes.com/2010/12/05/business/05ge.html?pagewan...
davi··on Google bidding up to $6B for Groupon
Dupe, HN discussion here: http://news.ycombinator.com/item?id=1953150
davi··on Google's Current Bid for Groupon: $5 Billion.
On the face of it this is hard for me to understand.

Here's the way I can rationalize it: imagine Google spends $20 million (or whatever) to build underlying technology. Then spends $2 billion to roll out a nationwide sales force sufficient to saturate all cities of some threshold size, and another $1 billion for a nationwide marketing campaign to introduce the project to consumers, all over the course of 1 year.

On the surface this is a better deal. But does it remind you of anyone? Microsoft. This is what Microsoft does when they try to do something new. And all too often, they fail. One reason they fail is that it's hard to effectively mobilize thousands of people and spend gobs of money in a short amount of time. The effort is so big it threatens to crush itself under its own weight if it is not properly managed. And management is hard.

Google is essentially sidestepping this management risk by spending a ton of money. They get something that is in a working state, rather than trying to quickly deploy something huge and new. Money is (relatively) cheap to Google, but opportunities for low risk, significant growth into a complementary space are rare. So this makes sense for them.

Here endeth the half-baked disquisition.

davi··on Why is America so rich?
Your working definition of "American" seems blinkered. One of the sources of our cultural strength is the diversity of views that make up our intellectual heritage. In my opinion, RMS is a great American. John Muir, Edward Abbey, Wendell Berry, Helen and Scott Nearing. All great Americans.
davi··on What Alcohol Actually Does to Your Brain and Body
Funny that an article inventorying the effects of alcohol fails to discuss how it addicts some people.

[edit: I meant failure to discuss mechanisms of addiction to alcohol, which are at least as interesting the biochemical pathways by which alcohol is metabolized, if not as well understood.]

davi··on Steve Ballmer sells about $1.3 billion in shares of Microsoft
And when that's still $1.3 billion dollars, you know you have built a very big company.
davi··on Ask HN: Friends and Family offering large amounts of money, what do i do?
If you can't make your friends and family realize there's a good chance they'll lose all their money by investing in you, and the amount of money they'd be investing is a nontrivial fraction of their assets, you can't ethically take their money.

You have an obligation to look out for the best interests of your friends and family -- i.e., to take care of them -- whereas your only obligation to professional investors is to honor your contracts.

davi··on The real reason (climate) scientists don't want to release their code
on standardized platforms

This would be horrifying. Maybe it could work in some fields, but not in mine (neuroscience). What, I'm going to use Java v.<whatever> on Ubuntu v.<whatever> because a funding agency tells me I have to?

I agree with much of your post, but not this bit.

edit: I think much of the professional insecurity of my field -- which feeds into the stuff you're complaining about -- is driven by the fact that way more grad student positions are funded than there are academic jobs. I wrote about this in more detail here: http://news.ycombinator.com/item?id=470181

davi··on Ask HN: What are you reading right now?
‘Where’ and ‘what’ in the whisker sensorimotor system

http://www.weizmann.ac.il/neurobiology/labs/ahissar/new_page...

davi··on How HN Helped Manpacks Take Off
Interesting that HN now has enough reach that mainstream media mine it for new stories. From the transcript --

Andrew: How about that “Inc.” article? There was an article in “Inc.” which announced Manpacks, and then it asked other entrepreneurs to give feedback and suggestions for Manpacks. How did you guys get that article written about you?

Ken: The editor reached out to us in March. He said they would be interested in doing an article on Manpacks. Would you be interested in an interview? I said, of course.

Andrew: Okay. Was this after the Hacker News hit?

Ken: Yes. It was maybe a week and a half after.

Andrew: That’s so interesting. By the way, I found that other reporters will look at Hacker News and come up with stories. And then those stories end up just kind of growing and growing and feeding on each other.

davi··on A Plea to Amazon: Fix Mechanical Turk
Tell us where to sign up to be notified of beta.
davi··on How Hacker News ranking algorithm works
I'm curious about how you evaluate prospective algorithm changes. Do you roll out a change you think should work and then monitor, or do you have a corpus of e.g. flame wars you test against?
davi··on What Happens At Y Combinator
Reminds me of the opening to Anna Karenina: "Happy families are all alike; every unhappy family is unhappy in its own way."
davi··on InDinero’s Jessica Mah: This Is A 20-30 Year Company
Not that I really know either, but I found this useful:

http://www.kalzumeus.com/2010/09/02/new-trends-in-startup-in...

“You owe me $20, with interest. Don’t worry about paying me back right now. Instead, next time you raise money or sell the company, we’re going to pretend that I’m either investing with the other guy or selling with you."

So if indinero takes more money, the early investors could sell their hypothetical convertible notes to the new investors.

davi··on Ask HN: What will be Facebook's weakness?
Previous good discussion on HN: http://news.ycombinator.com/item?id=1603374
davi··on Once a Dynamo, the Tech Sector Is Slow to Hire
> "These higher skills have become commodities, said Catherine L. Mann, a global finance professor at the Brandeis University International Business School who studies the outsourcing of jobs. The programming language “C++ is now an international language,” she said. “If that’s all you know, then you’re competing with people in India or China who will do the work for less.”

This was the most interesting part of the article to me. Ruby on Rails is relatively obscure. Scaling web sites is relatively obscure. I bet there is a latency, probably inversely proportional to market size, between when a specialized tech skill is originated and when it has disseminated sufficiently that it can be outsourced.

So, there can be a simultaneous shortage and surplus: a shortage of talented developers working with recent technology, and a surplus of talented (and otherwise) developers who are only familiar with older technology.

davi··on The Start-up from Hell
Thanks. A few things caught my attention which haven't been discussed yet in this thread:

that was some of the nicest work I ever did -- it's interesting how destructive processes can also produce great work. (This is not to say that the results are worth the destruction.)

Take the feedback you receive and use it to improve the product but unless something is really trivial it is better to sell what you have than to make some promise you can not keep -- another general lesson I would take away is, "be very wary when the salesperson is allowed to write the spec". I bet this is true across all business domains.

Fred never did hire a replacement, and hoped that I would stay on because I would not let my buddies down. -- I think this dynamic is built into the business models of some companies, especially consultancies. You feel guilty if you go home to sleep while your friends are coding 'til their eyes bleed, even when the overwork is brought about by extrinsic factors (see above).

davi··on Apple hires Near Field Communication expert as mobile commerce product manager
via http://bits.blogs.nytimes.com/2010/08/16/apple-hires-mobile-..., which has a little bit of value-add
davi··on Brain's wiring: More like the Internet than a pyramid?
No. These synapses: http://synapses.clm.utexas.edu/anatomy/chemical/asymh.htm

EEG sensors measure large aggregates of activity.

davi··on Brain's wiring: More like the Internet than a pyramid?
This touches on my area of research. The 'pyramid' idea of brain function is essentially a straw man to jazz up the Science Daily article. It's been known for a long time (a century) that recurrent loops occur throughout the brain. The mystery is what these loops do, given the apparent hierarchical buildups of representation that seem to occur in sensory systems, particularly the visual system. (Also in the hippocampus, e.g. place cells, and other areas in all likelihood.)

I haven't read the paper thoroughly (http://www.pnas.org/content/early/2010/07/28/1009112107), but looks like the authors are using a strategy of systematic and tightly circumscribed injections of anterograde & retrograde tracers to map out, with unusually high precision, the inter-areal projections for a particular circuit they're interested in. This mapping of inter-areal connectivity is a little different from what I'm interested in, which is to understand how the many-to-many anatomical wiring diagram between individual neurons in a neuronal network relates to the transformation of information carried out by that network. In other words, they are mapping connections between areas, but I think it's likely that an additional level of resolution -- the mapping of connections at the level of individual neurons -- will likely be necessary (and probably insufficient) to crack brain circuits.

davi··on Ask HN: What can kill Facebook?
The only thing that can kill facebook is failure to innovate and evolve with the tastes of its users. This would open the door to a competitor to become the new 'cool place to be'. It will probably take 5-10 years to find out if this is going to happen. The internal 'move fast, break stuff' development model seems explicitly designed to prevent this.

Barring that (or some sustained operational mishap -- downtime, security breach, etc.), network effects make it unkillable.

davi··on Raise money in memory of a loved one with 1000Memories and WePay
Seems like increasingly you're an 'ecosystem manager' -- of HN, and of the broadening pool of YC-funded startups.
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