19 karma · joined August 10, 2023
At least that would give you more room to miss by a few hours a dose and not going haywire into withdrawal. Especially when anxiety is already a problem and withdrawal symptoms kicks back the anxiety stronger...
Hope you find something that suits you!
Doctors that tells you how to reduce the SSRI/SNRI are following what's available on the market, and generally the gap between doses is always huge and gives a big gap and so bigger withdrawal. Once I asked to a pharmacist if he could make smaller doses and he answered me to be like a good junky and open the capsules and cut them myself. I was a bit shocked at the moment, but at least it costs me less that him having to do it a that helped me greatly to reduce a SNRI without feeling too much symptoms.
So a good advice, is look at the half-life of the drug you are taking, and be a good junky and split the capsules or have liquid form to reduce by small amount.
Half-Life of Specific SSRIs
- Fluoxetine (Prozac): 4 to 6 days, with its active metabolite norfluoxetine lasting 7 to 16 days.
- Sertraline (Zoloft): Roughly 22 to 36 hours.
- Citalopram (Celexa): About 36 hours.
- Escitalopram (Lexapro): About 27 to 32 hours.
- Fluvoxamine (Luvox): 17 to 22 hours.
- Paroxetine (Paxil): About 21 to 24 hours.
Half-Lives of Common SNRIs
- Venlafaxine (Effexor): About 5 hours for immediate-release (extended-release has an effective transit/clearance profile, though parent half-life remains short); its active metabolite (desvenlafaxine) has a half-life of about 11 hours.
- Desvenlafaxine (Pristiq): About 11 hours.
- Duloxetine (Cymbalta): About 12 hours (range of 8 to 17 hours).
- Levomilnacipran (Fetzima): About 12 hours.
Keep up the good work and I hope this will bring a lot more packages that will make this ecosystem a little more up-to-date!
The craze about disposable vapes is likely to come from teens and young adults who don't want to take the time to learn how to use a rebuildable vape and how to clean it. Also, it's easier to buy a disposable vape, use it, then throw it away.
I think that most of them are manufactured in China (to be profitable as one-time use with cheap labor), and although their factories seem to be of good condition, the materials they use to store the e-liquid and the heating part are surely well engineered but must lack some safety when consumed.
https://www.youtube.com/watch?v=J1ejAucYL0w -> Video of a vape manufacturing factory
Although the videos I've seen show mainly how the vapes are put together, not where the parts are created (which might be even more important to be of a high quality standard).
For the e-liquid storage:
They seem to use some sort of foam inside the e-liquid tank, which must serve to spread the e-liquid and let the user vape in any position. In traditional vapes, we just have some cotton to absorb the e-liquid through capillarity which guides it to the heating coil, but if we put the vape upside down or sideways some part of the cotton might not be in contact with the e-liquid and we would get a dry hit (burning the cotton and the heating coil gets hotter than when there's e-liquid present that vaporizes and cools it).
https://youtu.be/WohEiRvn2Dg?si=2mugWxWaBwd04T9u&t=71 -> Foam they use in the e-liquid tank
For the vaporizer / heating coils:
Lead and Antimony aren't supposed to be found in there (it has no use in the heating process / coil). For the Nickel, it must be the wire used to control the temperature of the coil and is indeed problematic if inhaled. We have better options with Kanthal A1 (ferritic iron-chromium-aluminium alloy) and stainless 316 steel wire if they want to control the temperature (even though Nickel is the most reliable to control the temperature).
https://youtu.be/WohEiRvn2Dg?si=O5fU1XUX1lwwBKBj
To end this comment, I find it concerning that they use this title without any education in mind, since most of the studies, when vulgarized by a journalist, are not always digging deep enough. We end up with a wrong interpretation and here it gives a bad vibe of "don't vape, it's harmful, go back to smoking cigarettes." Teens are not supposed to vape or smoke, but young adults must be educated, especially if they are trying to quit smoking, that instead of going back to cigarettes they should seek a professional shop where they can buy better products which are safer.