106 karma · joined October 25, 2019
My $20 sub using gpt 5.6 sol thinking-off lasts for hours using pi.
The one and only. Still online to my surprise.
EDIT 1: Just in time, UK Biobank (almost 500.000 people) study pointing to increased longevity with coffee consumers, an interesting controversy that just doesn't fit with their smaller study conclusion (although overall longevity is a different outcome, you would expect to find more dementia in older people) https://www.hsph.harvard.edu/news/hsph-in-the-news/coffee-lo...
- Go walk outside
- Consume media / go to events with topics that are VERY different than my field of expertise
- Do any kind of art
- Play like a kid
- Last but not least, my favorite: Have a lot of bad ideas. https://seths.blog/2018/06/the-two-simple-secrets-to-good-id...
Usually the highest level of evidence is attributed to randomized controlled trial studies. As the name says, they are performed in a high level of control, to evaluate in a more “insulated” way, the effects of a drug/intervention in a given outcome (reduce death, cure a disease, etc). Unfortunately, we can’t always relate these academic studies with the “real world”, due to an almost infinite number of confounding variables, or in the worst case scenario, if a scientist is manipulating the experiment environment (e.g. selecting a patient population with more likelihood for the desired effect).
This is one of the reasons why you will see with increasing frequency the terms “Real World Evidence (RWE) study” in reputable journals, such as the New England Journal of Medicine, or The Lancet.
These studies occur taking data from epidemiological surveillance, or patient medical records, and usually do a “reality check” on data found in these trials.
A lot of these RWE studies are famous to find problems that trials missed. Here is a classic example https://thalidomide.ca/en/what-is-thalidomide/
Based on what we already know about vaccine and PFF2/N95 mask efficacy and safety, it becomes hard to defend approaches such as ivermectin, instead of promoting practices and technologies that showed undeniable success in the real world, instead of doubtful medicines supported by obscure statistics and ideological discourse.
Although one should be aware of one very important git behavior - git does not diff binary files (like SQLite dbs). That means 2 things:
1. Each db update will generate a new file in git, maintaining the whole old file in history, instead of the diff in bytes. This will accumulate a lot of clutter in the repo
2. As git does not diff binaries, there is a very small risk of corruption (especially if you work in multiple OSs, because of CRLF)
Ref - https://robinwinslow.uk/dont-ever-commit-binary-files-to-git