dtawfik1

Pre-diabetes undoubtedly leads to impaired glucose metabolism in neuronal cells.

You'd find this pre-print interesting: https://pubmed.ncbi.nlm.nih.gov/36973715/

Part of the adaptation that enables a higher VO2 Max

The closest thing to acarbose would be a metformin analog berberine, but it doesn't have the gut microbiota remodeling benefits. In terms of rapamycin, it's probably not a supplement but multiday fasting.

I am glad you enjoyed it. I think Tim Ferris is a thoughtful person, but I think people have put too much attention on the hacking part of this particular book, and not enough attention on building mastery.

I'm glad you enjoyed it. It's my wife's essay, and it helped me make sense of the randomness of what happened.

Wow:

While I waited I wrote my will and made an Advanced Directive. There was a question where you could specify what you’d want to happen to your body after you died. I never thought I’d care about such a thing—why would I? I’d be dead anyway. But when I really imagined it, I did care. I wanted to be buried in a Jewish cemetery, somewhere nearby so the people who cared about me could visit. I didn’t want to be forgotten.

But… none of that happened because the tumor shrank with chemo, and I went into remission. Then I fretted about finding a match on the bone marrow registry, but there she was—my little German angel. Then I worried she’d change her mind, or that the stem cells would get lost in transit (she donated her cells in Germany before they were couriered to Los Angeles).

I worried when I was admitted to the hospital while I got total body irradiation and high dose chemotherapy to eradicate my immune system and prepare me for transplant. I worried right up until I saw with my own eyes the bag of cells hanging off the IV pole as they were infused into my body. Now, I only had to wait and see if the cells took, or if a I developed a life-threatening infection, or if I got graft versus host disease, when the donor’s cells attack your own body, which can have serious consequences.

But… none of that happened, either. Sure, I felt like shit in the hospital, but I didn’t have any major complications and after a month I got to go home. I worried about infection but I didn’t get one. I wasn’t supposed to eat takeout but one day I was craving pizza so my mom and I ordered delivery and I ate the pizza and nothing bad happened (we did have to hide the pizza box evidence from my husband because he had an eagle eye on me to make sure I followed all the rules, which I found adorable. I’ve never seen someone use so much Purell in their life).

Her section on praying it away is really interesting

This is the first preventative medicine clinic in Los Angeles

This is a type of fish oil that usually comes from krill. It has a higher capacity to pass the blood-brain barrier of carriers of the APOE4 gene.

The entire tech industry would not exist if we judged people based on this:

In its admissions process, Harvard scores applicants in five categories — “academic,” “extracurricular,” “athletic,” “personal” and “overall.” They are ranked from 1 to 6, with 1 being the best.

>Personally, early on, I made the mistake of thinking that an investor rejection somehow reflected on the viability of my ideas or my business, that they knew something I didn't.

Spot on. An idea stage company is a theory. Validation occurs through real users. To become despondent because an investor didn't believe in your theory is not allowing yourself to really test the viability of your project. If users don't buy into your idea then you have a problem, but you have to play the experiment out.

This is a bit of a tangent, but if you don't get in, don't read into it too much. The rejection could be due to many factors. It could very well be that you were rejected by the stage of your company. You may not have built out enough, or haven't had enough validation yet. I know a solo founder who didn't get in, but went on to raise 20m plus for his company (tuition.io). The fact that he was a solo founder and that he was still developing the product could have been the issue of why he was rejected. He went along to create a company that has 50+ employees. This is all to say you really have to develop the idea and see where your traction is to validate your idea. YC is a great organization to have backing you, but it's not always perfect in selecting great companies. Learn from the rejection, and apply those lessons, but commit to building a company.

Keep going. Do what you can to get traction and let the traction validate the idea. Validation of an idea by YC is a little bit of a crapshoot. Keep going and let the market validate the idea. If you don't get traction then re-evaluate things.

This is a bit of a tangent, but if you don't get in, don't read into it too much. The rejection could be due to many factors. It could very well be that you were rejected by the stage of your company. You may not have built out enough, or haven't had enough validation yet. I know a solo founder who didn't get in, but went on to raise 20m plus for his company (tuition.io). The fact that he was a solo founder and that he was still developing the product could have been the issue of why he was rejected. He went along to create a company that has 50+ employees. This is all to say you really have to develop the idea and see where your traction is to validate your idea. YC is a great organization to have backing you, but it's not always perfect in selecting great companies. Learn from the rejection, and apply those lessons, but commit to building a company.

This is a bit of a tangent, but if you don't get in, don't read into it too much. The rejection could be due to many factors. One thing that pops out is the stage of your company. You may not have built out enough, or haven't had enough validation. I know a solo founder who didn't get in, but went on to raise 20m plus for his company (tuition.io). The fact that he was a solo founder and that he was still developing the product could have been the issue. You really have to develop the idea and see where your traction is to validate your idea. YC is a great organization to have backing you, but it's not always perfect in selecting great companies

I’m glad you enjoyed the piece. I agree that there’s a lot of work pre-release in validating an idea to mitigate some of the risk.

Hi there. I am Daniel, the author. The post wasn't intended to be a slight at Tim Ferriss or the 4 Hour Work Week. I think Tim, is an interesting guy and he immerses himself in his craft, which underlies why he is as successful as he is. As other comments have suggested and what the post tries to make explicit is that the mindset of shortcuts and silver bullets is what is really what I found objectionable.

Thanks for pointing that out (quite embarrassing). I made those edits and I appreciate you bringing them to my attention/

If talking to your clients mostly gets you new feature requests, it either means your product isn't adequate yet or you're not asking the right questions. In a nutshell you want to get of feel of: - What was going on in your clients' heads before they found you. What precise problem were they trying to solve. This'll give you insights on whether or not your product is adequate, and on how to phrase your landing page. - How they went about to look for you. What google search they did, whether they checked out reviews and how, etc. this is to better focus your SEO and adwords campaigns. - What their decision process looked like. Was it a single person making the call, or were several people involved? What objections got raised? What were their key decision criteria? Raise them in your sales copy or in drip emails. - Are they talking about your product? Would they? This is to help you spot segments with viral potential. Don't forget to politely ask for referrals if applicable. - And, of course, feedback on the product itself. But don't spend too much time on this, and don't promise anything or build expectations.

If talking to your clients mostly gets you new feature requests, it either means your product isn't adequate yet or you're not asking the right questions. In a nutshell you want to get of feel of:

- What was going on in your clients' heads before they found you. What precise problem were they trying to solve. This'll give you insights on whether or not your product is adequate, and on how to phrase your landing page.

- How they went about to look for you. What google search they did, whether they checked out reviews and how, etc. this is to better focus your SEO and adwords campaigns.

- What their decision process looked like. Was it a single person making the call, or were several people involved? What objections got raised? What were their key decision criteria? Raise them in your sales copy or in drip emails.

- Are they talking about your product? Would they? This is to help you spot segments with viral potential. Don't forget to politely ask for referrals if applicable.

- And, of course, feedback on the product itself. But don't spend too much time on this, and don't promise anything or build expectations.

I am the author and I do agree with what you are saying. Our story was different. I mentioned that one of the original sins of our company was how we budgeted solely into product development. The other original sin was that the idea for the company was ill conceived. We had been working on tech at another company why not release as stand alone product. The idea frankly wasn't that differentiated enough from other products out there. When you don't have a truly differentiated idea like the companies you brought up, then marketing becomes more and more important to get peoples attention. Part of what made the examples you brought up special is that what they were working was so unique. That differentiation/uniqueness makes it a lot easier to market (the virality piece is more likely). In our case because we didn't have that. The way to survive was that we had to fight it out bidding for ads on Google. I would not recommend that path for anyone. It was just the environment we were in. I would say even for those companies to focus on marketing will not be a disservice, but focus on the initial conception of the idea even more. It makes a world of difference in determining what kind of head winds you'll face.

That's an interesting point that I hadn't really considered. Our startup never got to that stage. We raised money, burnt through it and then had to figure out how to salvage the situation being gritty.

yeah, very interesting

Definitely. Probably is a good resource for psychiatrist as a treatment strategy rather than a protocol for patients to self direct.

There's a lot of evidence that the body needs some meal restriction time to trigger autophagy, which has a lot of positive health outcomes.

https://www.uaf.edu/files/olli/OLLI_15_chol_4_red.pdf Checkout slides 7 and 8. My simple understanding is that the sugar creates a particle that provokes an immune response. Cytokines attack the sugar-lipid particle that has been oxidized.

Here's an article the consequences of inflammation on the brain. http://www.dana.org/Publications/ReportOnProgress/Consequenc...

Well, imagine inflammation in your circulatory system. So imagine that there's this partical in your blood stream that your immune system responds to. If you have too many inflammatory responses you could get a blockage. That blockage could lead to a heart attack.

That's one example but these inflammatory responses are also linked to a bunch of diseases. I hope that is a helpful answer.