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facetube

1,958 karma · joined April 15, 2015

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facetube··on What Sucks About Erlang (2008)
CouchDB. It's rare that a piece of software is bad enough to give its language and runtime a bad name, but it's actually that bad.
facetube··on Getting 1Password 7 ready for the Mac App Store
Yes, you're right, an already-dead company can't die a second time in this highly-hypothethical scenario. They're still dead.
facetube··on Getting 1Password 7 ready for the Mac App Store
We evaluated Lastpass about a year ago and the UI was borderline unusable. Doesn't matter so much for technical teams, but it does in broader use cases.
facetube··on Getting 1Password 7 ready for the Mac App Store
I keep meaning to write some Applescript and/or browser glue for pass(1). Uses GPG, checks into Git, and even has an iOS app.
facetube··on Getting 1Password 7 ready for the Mac App Store
> Maybe they should.
facetube··on Getting 1Password 7 ready for the Mac App Store
Removing the ability to get your own passwords out of your password management utility that you paid for would be corporate suicide.
facetube··on Card-Carrying Precadavers
Real place, real thing. [1]

[1] https://en.wikipedia.org/wiki/Genchi_Genbutsu

facetube··on New drug offers hope to those with severe migraines
I do. That actually seemed to add a great deal of absurdity to the situation. Doc was basically like "if it works use it, I have absolutely no problem; this would be one of the dumbest, ineffective, and most expensive way possible to do drugs recreationally".

The side-effect profile seemed a whole lot better than anything I'd tried, and it seemed far far easier to concentrate while it was doing its thing. It's also legal to travel with, and absolutely nobody seemed to know what it was by name.

But the funniest part was that the pharmacists seemed to be aware that the DEA scheduling was BS – I got carded for the bottle of wine I bought on the way out for a dinner, but not for the <ominous voice> DEA Schedule II controlled substance.

facetube··on New drug offers hope to those with severe migraines
Yeah, this was a case of being rushed out of an ER after a lumbar puncture (negative). You're apparently supposed to be held as an inpatient for at least a few hours while lying still; I was discharged in 15 minutes.

Mine ended up never self-resolving and they had to use a blood injection to produce a clot and "plug" the hole. Before that they tried IV caffeine – apparently that not only exists, but is actually indicated for spinal headaches. Trip report: meh, drinking coffee is much more fun.

facetube··on Limited airborne transmission of Ebola is ‘very likely,’ analysis says (2015)
Yeah, agree, that's a big miss.

Aside: there have to be better user interfaces for attaching dates to articles. Make the date more prominent/visible as it ages or something like that. The color of the date on that page is rgb(170, 170, 170) and seems very easy to accidentally skip over.

facetube··on Magazine publishers with video ambitions see YouTube as safer bet than Facebook
Twitter consistently pulls an absurdly low bitrate for the first 3-5 seconds of a video regardless of available bandwidth and it is maddening.
facetube··on New drug offers hope to those with severe migraines
> Paracetamol is not handling it, they often stop it, or rather, it stops the thing that is causing it to develop.

Actually, this is pretty interesting. I'd be really curious if NSAIDs like ibuprofen or naproxen have the same effect. APAP has a novel mechanism of action at the cannabinoid receptor type 1, because it's a prodrug for AM404. That's the only target that I've ever found that kills my migraines (N.B. prescribed synthetic, not so much smoking joints or anything).

facetube··on Bach at the Burger King
That's not what the article said.
facetube··on Bach at the Burger King
Why didn't he include gothic-industrial post-punk jam bands?
facetube··on New drug offers hope to those with severe migraines
A nonzero number of cluster headache sufferers have actually cracked their teeth from involuntarily clenching down in response to the pain.

It's possible OP has a more mild presentation or something, but what was described is pretty damned atypical – and also about a half-micron away from "I can, so why can't you?".

facetube··on New drug offers hope to those with severe migraines
> The symptoms are consistent with cluster headache

Out of curiosity, is that a professional medical opinion, or is that yours?

facetube··on New drug offers hope to those with severe migraines
Do you actually have a diagnosis of cluster headache from an MD?

The reason I ask: the pain from cluster headaches is legendarily terrible. The pain has been described as "remarkably greater" than migraine, and probably _at least_ on par with a spinal headache.

I don't have cluster headaches, but I've had a (diagnosed) week-long spinal headache exactly once before. A spinal headache is where your CSF fluid leaks out your back and your brain physically begins to "hang" in your skull. It lasted for a week, I was shot full of so much hydromorphone I couldn't physically coordinate my legs, and I was still in tears from the pain, begging doctors to knock me out. I honestly think I would have died by my own hands had it gone on for another week. It was unbearable.

I would suggest that the odds of someone managing cluster headache without medication – i.e. the headache that's earned the nickname "suicide headache" and causes people to carry around emergency inhalers of hardcore pain killers like butorphanol – is very, very low.

facetube··on New drug offers hope to those with severe migraines
Triptans do not abort my migraines. Hell, I suspect placebo might even outperform them for me.

The worst part: you pretty much have to pay a $1000 tax if you present at the ER with a migraine, because they will not believe you. People will be in a rush, they will not examine the giant history in the EHR spanning years and years, and you will be likely be suspected of drug seeking. So you have to say yes. $250 for a useless injection of sumatriptan and $750 for an hour of continuing to lie in pain on a bed until they hopefully realize you're telling the truth.

facetube··on New drug offers hope to those with severe migraines
No kidding.

I have taken intranasal capsaicin to try to stop the pain because a paper on the internet said it might work. It didn't even hurt. I'll repeat that: I snorted the active ingredient in habaneros and pepper spray and didn't even feel it because it was so far overshadowed by the pain in my skull.

facetube··on New drug offers hope to those with severe migraines
Very sloppy. Actually, just bullshit.

Approximately ten minutes before my pain starts, I begin to sneeze uncontrollably and vomit even with a completely empty stomach. This continues throughout the pain, and has lasted in excess of 72 hours before. They are spontaneous and there is no identifiable trigger, even after 25 years of looking.

How do you suggest I think my way out of this one?

facetube··on New drug offers hope to those with severe migraines
I don't think it's the right drug, but I think there's merit to that drug target.

I was prescribed a very expensive synthetic CB1 agonist for migraine nausea (nabilone) by my primary care MD, and the effect was instantaneous and miraculous. Killed the nausea outright, took a solid 80% off of the pain (it was doing the morphine-type "I can feel it but it doesn't hurt" thing), and there was no euphoria/high or noticeable drug craving or reinforcement that I could detect.

The bad news: it's $50 per milligram (almost $1500 for 10 days worth), Schedule 2 (the same schedule as fentanyl, cocaine, and methamphetamine), and technically approved by the FDA only for nausea caused by chemotherapy. The first FDA approval date for the drug was 1985.

I'd previously tried so many prescribed anti-migraine drugs I couldn't even list them all here in the time I have. The side effects were as debilitating as the migraines themselves in some cases. Some were just wildly inappropriate (e.g. a resident wanted to write opiates). Anyway, I fought with an insurance company for seven days on a $20k/year policy and they still wouldn't cover it.

Given the experience of trying to do this the right way, I'm utterly unsurprised that people in intense pain end up trying to DIY it.

facetube··on New drug offers hope to those with severe migraines
Do you ever use IV diphenhydramine in the ER when people present with migraine? Last couple times I hit the 48-hour mark and had to go in, I was surprised to get an IV full of Benadryl along with the pain killers.
facetube··on New drug offers hope to those with severe migraines
You may find that enduring years of frequent unpredictable debilitating skull pain that lasts for unpredictable amounts of time, causes hours of intense vomiting progressing to dry heaving, and is frequently dismissed by others because the pain isn't visible enough to be seen as a "legitimate excuse"... tends to help other parts of your life become disorganized.
facetube··on New drug offers hope to those with severe migraines
APAP metabolizes to AM404 in vivo, which acts indirectly on the cannabinoid receptor type 1. AM404 is likely responsible for a large amount of the pain relief (and, unsurprisingly, an anticonvulsant effect).

I suspect it's tolerance and not addiction, but docs see this and code it as "medication overuse headache" all the time.

facetube··on Drone Maker Accused of Covering Up Bomb in Bag on Delta Flight
They actually test for both components of binary explosives in the US TSA. Source: a TSA agent, while he was going through all of my things because I guess I touched a cleaning product with ammonia in it or something.
facetube··on The Wizard of Q
It's 4chan, I promise you
facetube··on US cell carriers are selling access to real-time phone location data
Exactly. Telcos recover damages, the products (read: users) who were damaged get nothing.
facetube··on US cell carriers are selling access to real-time phone location data
I buy burner phones and SIMs all day every day as test equipment because I develop for mobile equipment. Sue me, assholes.
facetube··on US cell carriers are selling access to real-time phone location data
And ethernet and 802.11 receive every frame, whether it's addressed to the equipment or not.
facetube··on US cell carriers are selling access to real-time phone location data
Corporate big brother will actually help them put you in jail if it's profitable.
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