Yes, the way Michael Grandner explains it in this podcast[0], melatonin is an ancient molecule that signals, "it is dark." If you give it to nocturnal species, it wakes them up!
1,097 karma · joined October 5, 2010
Yes, the way Michael Grandner explains it in this podcast[0], melatonin is an ancient molecule that signals, "it is dark." If you give it to nocturnal species, it wakes them up!
[0] https://web.media.mit.edu/~raskar/trillionfps/
EDIT: Video with explanation. https://www.youtube.com/watch?v=EtsXgODHMWk
The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53.
[0] https://www.foundmyfitness.com/episodes/ben-bikman
EDIT: ycopilotFYT version https://www.cofyt.app/search/dr-ben-bikman-how-to-reverse-in...
[0] https://podcasts.apple.com/us/podcast/the-rich-roll-podcast/...
I think this is overstating the risk in supervised clinical usage, depending on what you mean by "some level of damage." It's possible that a single alcoholic beverage may induce some level of damage, but that is irrelevant for most drinkers. A more realistic comparison might be the risk associated with surgical anesthesia, which is significant, but that doesn't mean surgery should be necessarily avoided. There are always risk/benefit tradeoffs, and the MAPS research has focused primarily on MDMA use after other therapies have failed.
The MAPS Investigator's Brochure[0] acknowledges that, while preclinical studies in animals have shown serotonergic neurotoxicity at high or repeated doses, there is as yet no consistent evidence of neurotoxicity in controlled clinical settings with limited dosing. The report characterizes high-, medium-, and low-level risks. No high-level risks were identified, and medium-level risks are mainly cardiovascular and psychological.
[0] https://maps.org/wp-content/uploads/2023/04/MDMA-IB-15th-Edi...
I put that statement to ChatGPT, and it reminded me of Churchill's "We Shall Fight on the Beaches"[0] speech, which is defiant, rather than optimistic.
Once again we seem to be in dire circumstances, on the brink of colossal ruin, owing the the whims of a handful toxic people, and the ignorance of so many who put them into power. I'm not at all optimistic, but I can try for grim determination.
[0] https://winstonchurchill.org/resources/speeches/1940-the-fin...
Maybe you should, if Eleanor Maguire's research on "The Knowledge" and the hippocampus has any bearing.
https://www.nytimes.com/2025/02/14/science/eleanor-maguire-d...
We used to have Spectrum, but switched to Frontier Fiber as soon as it was available, a couple years ago now. Apart from a few hiccups during the first few weeks of service, it's been very reliable.
I think the defacto rule that many drivers follow is, 'if the intersection appears clear, I don't have to stop.' (I'm not advocating this rule, just saying what I think the rule is.) Cell phones and screens in cars have made this rule especially problematic because drivers aren't paying close enough attention to the road to ascertain whether intersections are clear.
This isn't a recent phenomenon in LA, but it seems to have increased during and since Covid. I'd love to find reliable data on traffic enforcement. The problem is cultural, but the apparent lack of enforcement seems to have expanded the population of scofflaw drivers.
Do you have any evidence to support that? It would be fascinating if the field is primarly advancing due to a unique constellation of traits contributed by individuals who, in the past, may not have collaborated so effectively.
Yes, indeed, that would attest to your mental state!
Slightly off-topic, I've wondered whether serial numbers are captured on bills processed through an ATM. Bill are also put through machines when human tellers receive them at a bank. These days it wouldn't be that hard to track the currency flows, although intermediaries would not be visible.
There needs to be some kind of work product doctrine, which protects the privacy of routine business communication. Defining that, while allowing the collection of evidence of criminal activity, won't be easy, but the current state of affairs is unworkable.
I don't wish to facilitate corporate crime, and it's obvious that some of Google's anti-competitive behavior is unlawful. But, I don't see any realistic alternative to what Google is doing in the current legal environment.
When the system was new, there was a reasonable warning ahead of time on the battery level, but now the warning is not sufficient for a work around, and the mouse much be charged within a minute or two.
I'm reminded of the situation where General Motors kept thin, uncomfortable metal keys decades after other manufactures released more ergonomic keys, or even remote key fobs.
Attached https://www.amazon.com/Attached-Science-Adult-Attachment-You...
A General Theory of Love https://www.amazon.com/General-Theory-Love-Thomas-Lewis/dp/0...
Attachment Disturbances in Adults: Treatment for Comprehensive Repair [academic/professional text] https://www.amazon.com/Attachment-Disturbances-Adults-Treatm...
2) It's harder to make friends as you get older. Most friendships are built on an ongoing shared experience that is challenging, such as being in school together. Most of my adult-onset friendships are a result of having worked in small startup companies that were struggling to survive. Casual meetings of potential friends are much less likely to generate the energy and commitment for developing a friendship. If you're interested in the research on this, look into the work of Robin Dunbar, e.g.,
Friends: Understanding the Power of our Most Important Relationships https://www.amazon.com/Friends-Robin-Dunbar/dp/1408711737/
For many people, sadly, one can never be rich enough. My point is, planning for both short term exit, and long term gains, is essentially the same in this particular situation. What a boon! Nice problem to have!
This reminds me, the artist Gregory Blackstock retired with a union pension at 55 after 25 years' service as a dishwasher[0]. His art provided another source of income, but apparently he was swindled out of his estate.
https://www.usgs.gov/media/images/aerial-view-isaac-hale-bea...
https://www.google.com/maps/@36.5481627,-121.9235433,3a,73y,...
I feel bad for map developers. Searching Google Maps for Carmel House yields a house at 26177 Scenic Rd, not the house at the above link.
Within Carmel-by-the-Sea, some addresses on Zillow are like "Lincoln 7sw 13th," but that address is not known to Google Maps.
https://www.zillow.com/homedetails/Lincoln-7sw-13th-Carmel-B...
Certain addresses on Zillow appear to be in standard form, such as 225 The Crossroads Blvd, Carmel, CA 93923, but notice the URL isn't Carmel-by-the-Sea. EDIT: Nevermind, that address is clearly erroneous, the house is on Delores St.
https://www.zillow.com/homedetails/225-The-Crossroads-Blvd-C...
Putting that address into Google Maps returns a location in The Crossroads Shopping Center, not the location in Zillow.
Years ago, I had to routinely redo my searches for Carmel addresses, since Google Maps assumed I was referring Carmel Valley near San Diego, zip 92130, not Carmel-by-the-Sea. That changed at some point; Carmel now "redirects" to Carmel-by-the-Sea. There is also a Carmel Valley zip 93924, east of Carmel-by-the-Sea.
Here's a house on Zillow, with the house number clearly visible. https://www.zillow.com/homedetails/26387-Isabella-Ave-Carmel...
Google Maps https://www.google.com/maps/place/26387+Isabella+Ave,+Carmel...
Apple Maps https://maps.apple.com/?address=26387%20Isabella%20Ave,%20Ca...
There is something fishy though.
Searching for the address in Bing Maps shows the correct structure, but I can't seeem to generate a link with the address. The link is lat long. https://www.bing.com/maps?cp=36.54084%7E-121.930825&lvl=19.7
Open Street Maps address queries don't seem to work, and when I select that location on the map, the geocoded address is incorrect but close. https://www.openstreetmap.org/directions?from=36.54084%2C-12...
What Carmel needs are affordable addresses, but that's a different problem entirely.