300 karma · joined August 22, 2011
This is a frustrating type of issue. Dismissing something with "I don't understand this, but I don't believe it" isn't the sort of thing I want to be doing. However, I don't have any desire to waste time trying to understand what someone has done (and did they really understand what they were doing themselves?) when it's clear that the effect isn't cleanly isolated in the data and no amount of mathematics is going to change that.
There are plenty of studies showing that caloric restriction calms inflammatory responses which are responsible for the majority of common diseases. Without balancing the energy intake, I'm always slightly suspicious that any improvements with changing what I eat are actually caused by the change in how much I eat.
Anecdotally, when I start (or re-start) running I find the pace I can run at increases quite rapidly. That makes sense with this data - although my fitness is only increasing slowly, being able to produce slightly more power actually gives a disproportionate increase in pace because the higher speed is more efficient per km.
Another proposed idea for places that have deep seas or lakes is pumping air down into a storage at the bottom of the water. This storage can even being a flexible plastic - there isn't any high loading on it because the pressure balances out. The issue with that tech is that it's not that efficient, as compressing the air going down generates a lot of heat - some of that could potentially be recovered, but there's a trade-off with simplicity. Also if the containment fails then a lot of air bubbles to the surface, potentially sinking any ship on the surface at the time.
One potential WFH efficiency loss for me is that due to casual conversations or things I overheard in the office, there were many occasions when I knew that someone had already investigated something or that some issue had come up that explained symptoms I came across, saving unnecessary duplication of effort or implementing something which wasn't quite what was required. You might argue that this level of communication could be achieved remotely, but maybe you'd end up with nearly the same level of distractions.
I will add that my commute was a 15-minute cycle, and my employer provided me with lunch, so probably going to work was actually a net time saving for me (certainly if you consider the commute exercise time), which may explain why I'm less keen on WFH than most.
I don't want to be that person who thinks a really complicated thing should be trivial, so: Can anyone suggest why it would take weeks to approve these vaccines? What might the regulator actually be doing in this time?
They're clearly going to know that the request is urgent, and know when it's going to be arriving in their inbox; they could ask for anything apart from final data ahead of time to check everything is as they want it. I don't see why they can't have made sure they were happy with everything else ahead of receiving the final data.
Even if we suppose the chance of it being as bad as suggested is only 50%, we should panic now, rather than waiting until we have solid proof and risk having a public health disaster.
Personally I suspect the UK didn't panic in its announcement and that this situation had been under surveillance for some weeks.
2. I spend an unhealthy amount of time looking at data. Before this incident there were always random peaks which got explained by outbreaks at abattoirs or freshers' week, and national movements, but this change stood out. Week after week it kept behaving differently. My partner and I had already speculated about the change possibly being down to a mutation, since although that seemed incredibly unlikely nothing else explained what we were seeing, but dismissed that idea since obviously the authorities would have noticed. It turned out they had noticed, they just hadn't announced it.
3. A quick calculation: recent infection surveys suggest about 1% of people in the UK have the virus. The new strain makes up about 10%, so 1 in 1000 people have the new strain. In November 2020 from Heathrow alone, 240k people travelled to the EU, 68k to other European countries, 63k to Africa and 82k to North America.
If I remember correctly cases have already been found in Denmark and Australia. Denmark does more sequencing than most countries (I don't have a good source for that, but there by-country filters here imply it: https://nextstrain.org/groups/neherlab/ncov/united-kingdom?c... )
Based on this I'd argue that it's more likely than not to already be in tens of other countries. I'd certainly be interested to hear arguments to the contrary. But I don't believe it's sensationalist to suggest this - at this point I'd consider it a miracle if it hasn't spread too far. I hope I'm wrong.
Now high case counts are spreading from the South East into the rest of the country. We don't know whether we can even stop the growth. During the last lockdown schools remained open; I suspect that it may be necessary to close them in order to just stop the growth. A significant reduction in cases looks impossible.
This strain has probably already spread to tens of other countries. Every country which is just about holding things together, whatever their strategy, is going to struggle with a significantly more transmissible variant of the virus.
https://www.bbc.com/future/article/20201112-the-green-hydrog...
I don't know what the regulator will do about this situation; it's clear that the vaccine is effective in at least one of the dosing regimes administered, but being entirely certain as to which is better is probably impossible to determine from the data available.
For example a government interested in reducing CO2 emissions could introduce a tax on motor fuel of say £1/litre and balance that with an increase of the basic income of £75/month.
There are significant resources going into scaling up new testing technologies, but it's definitely not getting the support that vaccine development is, and maybe it should.
If people can, good for them. If not, I don't feel in any position to tell people that obsessing over injustices that I'm not experiencing makes zero sense.