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hex4def6

1,234 karma · joined October 2, 2020

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hex4def6··on Fructose in diet enhances tumor growth: research
I feel like I came across some similar research years ago.

It brought up a question that I'm hoping someone in this field could answer: Does it make sense to speed up cancer cell replication while providing chemo drugs?

It seems like this would result in greater discrimination between fast-replicating cells (cancer) and normal cells. In turn, this would allow faster chemo treatments, or less collateral damage.

hex4def6··on Facebook's Little Red Book
I agree with all of this, but would add: The "social media" we see isn't the entire landscape. There are lots of small communities hanging out in spaces like unpopular subreddits, random internet forums, discord servers. It's just the 10GW burning sun that is popular social media can feel like it drowns that all out. And, I think there's a bit of a nagging feeling of irrelevance that can creep in when you're in these niches.

In the old days, you were small groups exploring the uncharted. You were in the minority because you were part of a group of pioneers, and I think there was a sense of optimism and excitement around that. I think a lot of the magic is gone precisely because tech is now ubiquitous and mainstream.

I can't help but wonder if it's my nostalgia as well, but I feel like 1995 - 2005 was the golden decade. It was at the point that technology was actually good enough to enable a lot of stuff (broadband, large storage media, etc), but it was still enough in its embryonic state that the novelty was still there.

hex4def6··on Yes, it ‘looks like a duck,’ but carriers like the new USPS mail truck
"While the all-aluminum body of the LLV has resisted corrosion exceptionally well over the years, the main powertrain components have been replaced multiple times and now must be sourced through aftermarket manufacturing. This has significantly increased repair costs while reducing performance and reliability.

In fact, the Postal Service had to contract an alternative supplier to reverse engineer and manufacture the chassis frame to keep the LLV operational. As a result, the average annual maintenance cost exceeds $5,000, with 7% of LLVs exceeding $10,000 annually. Additionally, they are less fuel-efficient and unsuitable for future delivery needs given projected changes in market demand, mail mix, and increasing delivery points.

The LLVs also lack modern safety features such as airbags, anti-lock brakes, air conditioning, back-up cameras, blind-spot warning systems, daytime running lights, and seatbelt reminders." https://uspsngdveis.com/documents/USPS+NGDV+FEIS_Dec+2021.pd...

Sort of a Ship of Theseus vehicle. Yes, some have lasted over 40 years, but that's with potentially multiple drivetrain replacements, at an annual maintenance cost of $5,000 - $10,000. That feels high, given how simple those vehicles are.

hex4def6··on Ask HN: Great maker projects for 8th grade kids and above?
My kiddo has a couple of those, and I'm still in two minds about some of the choices that they provide in those kits.

It feels a little like "Follow these instructions exactly" without requiring understanding in a lot of cases. For example, the music IC doesn't have any of it's terminals labelled.

The same with the transistor; it doesn't seem to explain exactly why you'd need to use it, why you'd need a resistor on the base, etc. On that note, It's also possible to potentially damage stuff if you just try to experiment without understanding.

I feel like they could have made some of the parts a bit more flexible -- have current limiting resistors built into the LED & transistor units for example, provide point-to-point wires rather than rigid 1/2/3 unit connectors, etc etc.

hex4def6··on Yi Peng 3 crossed both cables C-Lion 1 and BSC at times matching when they broke
The exercise left for the reader is to choose two countries that are not adjacent,

and try to plot a path between them without crossing an undersea cable:

https://www.submarinecablemap.com/

hex4def6··on California new law forces digital stores to admit you're just licensing content
This changes nothing, other than making companies replace all instances of "buy" with "add to account".

What I'm more interested in are laws against "changing the experience". You force a mandatory update that significantly changes the product in a way that I don't like (removing features or cramming ads into a device I paid for), I should have the option to revert to the original as-bought configuration, or get a complete refund.

hex4def6··on Drift towards danger and the normalization of deviance (2017)
Wow. Ignoring the proximate cause of leaving that code in there, imagine being the poor schmuck that forgets to deploy a code update to 1 of 8 servers, causing $440 million in damages, basically destroying a company overnight. It's so far outside of comprehension at that scale.
hex4def6··on Fixing an Elgato HD60 S HDMI capture device with the help of Ghidra
I agree with the sentiment, but:

To what level would the "source code" have to be published? Chip-level? Should I expect HDL code that allows me to reproduce the microcontroller? If not, expect a bunch of gadget companies to pay cypress or whoever to make "custom" chips with their firmware burned in. After all, what's the difference at that point between HDL and firmware?

If yes, expect most companies to simply refuse, and not authorize their chips for sale in the US. International IP / licensing agreement would make it literally impossible for them to comply without being sued into oblivion by the Taiwanese company they licensed the IP from.

I think stuff like design files and source code should be held in escrow by the government. If you continue to provide replacement parts to customers, the information remains protected. Once you stop providing reasonably priced replacements ("reasonably priced" = less than the cost of the product), the information gets published so others can reproduce it.

hex4def6··on Microwave spontaneously turned on by its LED display
Link seems dead. wayback version: https://web.archive.org/web/20240910031602/https://blog.stuf...
hex4def6··on The Early Days of Valve from a Woman Inside
I don't know if I read that as hubris. What else could they do? If they say "no," and this truly is something she's interested in, they risk losing her completely.

I think it sounds like they were remarkably accommodating. I doubt you'd find many companies these days that would grant the same sort of deal.

hex4def6··on Oakland's new school buses reduce pollution and double as giant batteries
In theory such a thing is possible. In fact, I've even sketched out what I'd need to do to my one to convert it. I may still do it as a science project -- it's an old unit (~2007), so if I destroy it it's not the end of the world.

I can completely understand why no HVAC company would want to touch such a project. It's entirely experimental, would take a skilled technician, and has a high chance of not working perfectly. They would much rather slap together 2-3 installs in the time it would take to plan and assemble your science project. Remember that most of their techs are literally just installers, and there's a huge incentive to "rip out and replace" rather than "diagnose and repair".

If you could find a retired HVAC tech, you might be able to convince them to help.

hex4def6··on UK rail minister got engineer sacked for raising safety concerns
I'm not sure being reminded not to slip would reduce my likelihood of slipping.

Seems like things like making sure floor transitions are mild, adequate drainage, textured floors would be more effective. (polished stone and concrete are a nightmare with some shoes that I own in wet weather).

hex4def6··on Air Con: $1697 for an on/off switch
Because USB is not a multi-tap network. It's a point-to-point between host and peripheral, or host and host pretending to be a peripheral (OTG mode).

That USB dongle was bodged on to the USB port D+/D- pins going to the tablet's SOC. If you then connect a PC to that port, you have two hosts (SOC & PC), and one peripheral on the same pair of data lines. No bueno.

I can't believe the bodge job inside that tablet. It looks like the prototype became the final product.

hex4def6··on Microsoft security tools questioned for treating employees as threats
I question you "1 in 1M". I think it's probably multiple orders of magnitude more common that that. There is a continuum of how damaging that data leakage is, and/or who the data is flowing to.

Just through personal anecdote, I can think of maybe 5 examples of people I directly know 'retaining' stuff like outlook email PSTs, training documents, etc. And I'm sure there are many more people in my immediate circle who have done similar stuff.

The espionage situation is perhaps more rare, but still prevalent. It's a common situation for people to hang around outside the Foxconn campus soliciting data for the latest iphone / what-have-you. Lots of money to be made have a 2-3 month jumpstart on your competitors when you design a 3rd-party case, for example.

hex4def6··on Sainsbury Wing contractors find 1990 letter from donor
Pretty sure that was laziness, not foresight on their behalf. Builders leave a lot of trash in walls.

Not very useful to find once you've crushed up half the existing tiling.

Breaking up the 50 year old concrete pad near my house, I found old 1970s crushed beer cans buried under the concrete (the kind that predate the attached pull-tab). Kind of a neat link through time, imagining them sweating in the same sort of heat that I was.

Of course, it might also explain some of the other 'questionable' issues in the construction that I keep finding...

hex4def6··on Secure Boot is broken on 200 models from 5 big device makers
This has been my theory since Windows 11 required TPM. It's not to protect the consumer, it's to protect the IP-holder.

The PC is the lone outlier in the locked-down, walled-garden world of consoles, cell phones, tablets, smart TVs, EVs, etc. I think there's a concerted effort to change that.

hex4def6··on A free tool to quickly detect counterfeit flash (2017)
The issue is that if you exceed the (invisible) limit, you start overwriting the existing data. That's Bad (TM), since there's no indication that it's happening, until you attempt to retrieve the data and discover it's corrupted.
hex4def6··on Why Delta is still canceling flights as other airlines return to normal
That sounds infuriating.

3 hours of travel time, plus 20 minutes for hotel check-in, plus 15 minutes for checkout, plus 15 minutes for waiting for the shuttle x 2, plus 10 minutes of walking to the bus stop, and that's 4:15 before you even hit the pillow.

That would put you at 5:15 AM, 45 minutes before the plane departs. Delta recommends you be at the airport at least 2 hours before the plane departs. So by their own recommendations, there is no way this could work, even assuming you didn't even head up to the room.

hex4def6··on Ask HN: How do browsers isolate internal audio from microphone input?
Assuming OP is correct, your last sentence implies this isn't the solution being used.

Additionally, many (citation needed) Youtube videos have people talking in them; this method wouldn't help with that.

Isolating vocals in general is significantly more difficult than just relying on frequency range. Any instrument I can think of can generate notes that are squarely in the common range of a human (see: https://www.dbamfordmusic.com/frequency-range-of-instruments...)

hex4def6··on Moaan InkPalm Plus is weird, cheap, small, and my kind of e-reader
I haven't kept up with ereader stuff for many years since I worked on battery life models for kindles, but I will say that keeping your e-reader in airplane mode will increase the battery life significantly.

The reason is that WiFi has a DTIM which basically means that requires periodic wakeups to keep associated with the AP. This burns power.

hex4def6··on Show HN: I built a JavaScript-powered flipdisc display
It would be really cool if you could read out the state of the grid as well. You could then use the display as SRAM. Would look very cool as part of the world's slowest microcontroller.
hex4def6··on Nano DIP: the smallest complete Arduino board 33 x 10mm
At a certain point, if you're going for "smallest", it's a bit of a cheat not to include Z-height, especially if you're relying on a vertical micro-USB connector in your design.

45x18=810 vs 33x10=330, great. But If you're adding another 5mm z-height for a connector, the volume is now kind of significant.

Just think of the stack-up at this point: Motherboard + female socket (1.6mm + 5mm?) + daughterboard (1.6mm) + pins (5mm?) + vertical USB (5mm?). You're looking at something that's +/-18mm tall. Given that this whole design is basically just a way of attaching a 1mm tall IC to a design, that starts to feel a bit extreme if you care about size.

If you really care about a tiny board, and don't need the DIP compatibility (or removability), I feel like a castellated design that can be soldered down is more useful. Designs like the Piksey Atto (20x13 = 260, but also something like 5mm tall)

For me, the killer feature of not having the microcontroller soldered down is that you can flash something on a dev PC, and then insert it into the device.

But in that case, I like something like the tinyduino, which eschews .1 headers and uses a B2B connector. More of a pain to deal with, but you get the benefit of tiny size + low z-height + removable: https://tinycircuits.com/products/tinyduino-processor-board

Regardless, more options are always better. But it's also useful to really think about what your requirements really are.

hex4def6··on Nature retracts paper that claimed adult stem cell could become any type of cell
Riffing on this,

I wonder if you could assign a citation tree score to each first-level citation.

For example, I cite papers A,B,C,D. Paper A cites papers 1,2,3,4. Paper 1 cites a retracted paper, plus 3 good ones.

We could say "Paper 1" was 0.75, or 75% 'truthy'. "Paper A" would be 3x good + 1x 075% = 3.75/4 = 93.7% truthy, and so on.

Basically, the deeper in the tree that the retracted paper is, the less impact it propagates forth.

Maybe you could multiply each citation by it's impact factor at the top level paper.

At the top level, you'd see:

Paper A = 93.7% truthy, impact factor 100 -> 93.7 / 100 pts

Paper B = 100% truthy, IPF 10 -> 10/10 pts

Paper C = 3/4 pts

Paper D = 1/1 pts

Total = 107 / 115 pts = 93% truthy citation list

If a paper has an outsized impact factor, it gets weighted more heavily, since presumably the community has put more stock in it.

hex4def6··on Disrupting deceptive uses of AI by covert influence operations
"Our Usage Policies prohibit the use of our services to deceive or mislead others. This includes deceiving people about the authorship or source of content generated using our models, by engaging in activities such as: ... Creating automated systems that falsely present as being a real person, or don’t disclose to people that they are interacting with AI (unless it’s obvious from the context)."

Suspiciously absent from the list of takedowns is anything on Reddit. Given the amount of obviously-chatGPT puppets on there, I'm somewhat 'surprised'.

Also a good reminder that if you're using ChatGPT for anything, they can and will examine the traffic and contents of your messages / replies.

I wonder if in the future they may offer a "service" to content providers. Say you're a reddit / forum / etc. You get supplied an API that you can run queries through that match any content that may have been generated through their service. You can then tag those accounts as bots. Of course, such an API will have costs associated with it...

hex4def6··on 120cm to inches
seems like 1-106cm is fine, and then it stays incorrect up until 199cm, at which point it's correct again.

Truly a bit of a wtf.

hex4def6··on The case against dual axis charts (and what to use instead) (2018)
As an engineer with an oscilloscope, not being able to plot two probes against each other on the same chart would be severely limiting.

For instance, imagine a 10x attenuator / amplifier. Maybe the input has a DC offset. Being able to plot the two against each other to look for (e.g) distortion, is invaluable. This is committing the two cardinal sins (judging from some comments here) of not starting at zero and different scales, and yet it's not misleading at all.

I can believe dual axis charts allow misleading results, but that doesn't mean they don't have completely legitimate uses.

hex4def6··on The case against dual axis charts (and what to use instead) (2018)
In that case, we should report body temperature in Kelvin. However, now the dead-alive range (95degF - 107degF) becomes 308K to 315K.

Starting at zero, that range (17K) is now only 5% of the graph, assuming we start at zero. Or in other words, if your chart is 10cm tall, the entirety of the useful range is compressed into a space that is 5mm tall.

hex4def6··on Growing sodium chloride crystals at home
I wonder if it's a container cleanliness issue. I can imagine dishwasher detergent residue might leave trace chemicals that mess up the formation.

I also wonder if the smoothness of the container has an effect. A rough surface might encourage lots of seed sites.

hex4def6··on Slack AI Training with Customer Data
I'm confused about this statement: "When developing AI/ML models or otherwise analyzing Customer Data, Slack can’t access the underlying content. We have various technical measures preventing this from occurring"

"Can't" is a strong word. I'm curious how an AI model could access data, but Slack, Inc itself couldn't. I suspect they mean "doesn't" instead of "can't", unless I'm missing something.

hex4def6··on Glider – open-source eInk monitor with an emphasis on low latency
Yeah.

I like tools that do one thing well. The Kindle has hit that spot for a long time. There were incremental improvements (faster processor, 3G/4G, front light, higher DPI / contrast, etc), but it's surprising how similar a 2010 kindle is to a 2024 one.

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