But first one must be able to connect with people... since I can’t do that, the rest is considered behaviors of an pointless, unrespectable, unworthy fool, while everyone else is mostly “take, take, take.”
180 karma · joined November 17, 2017
#ifndef SUCCESSFUL_H_
#define SUCCESSFUL_H_ 1
#ifdef __cplusplus
extern "C" {
#endif
int will_code_for_awesome_benefits(void);
#ifdef __cplusplus
}
#endif
#endif /* SUCCESSFUL_H_ */
The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.
2.3 Metabolites
The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.
(Table 1 - 22 metabolic variables considered)
https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095
I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.
PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr
- Object contains a Class that it derrives from (no BaseObject or Modules)
- Class is an Object
- String is an Object
- Boolean is a two-value singleton of true and false
- Number is an abstract subclass of Object
- Decimal and Integer are abstract subclasses of Number
- Float, Double, LongDouble, BigDecimal are concrete subclasses of Decimal
- SignedByte, Byte, Short, UnsignedShort, Int, Unsigned, Long, UnsignedLong, Char, BigInt are concrete subclasses of Integer (or U/I/F## types reminiscent of Rust instead of C type names)
and so on.
Then there is no boxing/unboxing of simple types or literals because they are one-and-the-same, and no there’s no confusion about how to interact with any truly generic type of value.
Another fail is “recycling” at Costco, where basically no recycling happens and people just throw things in carelessly into any of the 3 bins. Worse, the staff contribute to its demise equally by eliminating the sorting signs and turning bins around to hide their labeling. Red, green, blue ... go figure which is which.
It’s not just fertility that declines, but IQ and a rise in birth defects.
It’s the opposite of virtue-signaling if you live and work for what’s right, not out of what’s most expedient or wins popularity points, but out of integrity. Too few people these days have the courage to think deeply and act consistently regarding the big issues impact of their choices of consumption, associations and work income. (Focusing too much on tiny issues would exclude everyone.)
Collapse by Jared Diamond
The History of the Decline and Fall of the Roman Empire by Gibbon
Brevísima relación de la destrucción de las Indias (English: A Short Account of the Destruction of the Indies ) by Bartolomé de las Casas
In Ruby,
a.map(&:succ) ++x; // x = x + 1
&:foo Ruby method name to callable syntax
foo&.bar Ruby check nil before calling bar
foo?.bar Swift optional presence check
if(x = foo!.bar!) {
x.something()
}
foo ?? bar Swift nil-coalescing
foo || bar Ruby nil-coalescing
<<1,4,8,45>> Erlang bit syntax (binary literals), with typing and endianess
5b432140 Erlang arbitrary base literals
List comprehensions Erlang, Python,
Binary comprehensions in Erlang
2> Pixels = <<213,45,132,64,76,32,76,0,0,234,32,15>>.
<<213,45,132,64,76,32,76,0,0,234,32,15>>
3> RGB = [ {R,G,B} || <<R:8,G:8,B:8>> <= Pixels ].
[{213,45,132},{64,76,32},{76,0,0},{234,32,15}]
-- from LearnYouSomeErlang
Show anon fn’s in many languages using utf8 λ.
Swift property lifecycle callbacksGive life, donate blood etc.
- hard limits, priorization and accounting metrics of all resources, incl.: IO, storage, compute, mem, net, kernel structures
- provable isolation / no side-channel leaks
- SELinux
- Live migration of processes and storage to different hosts, suspend/resume
- Type 4 hypervisor containers for different kernels, OSes, etc. configured and managed seamlessly with the same API
Then and only then can the jumble and complexity of containers running on hypervisors go away and be more like SmartOS with an ability to run bare-metal without losing devops flexible capabilities of running T4 hypervisors under everything.
A hypothetical kernel&userland like OpenBSD built on seL4 (a-la DragonFly or MINIX 3), implemented in Rust, OCaml or Haskell, with thorough unit, integration tests and perhaps formal proofs, seems like the safest, not necessarily the fastest, kernel approach possible using modern technologies. seL4 communicating by sending messages is really efficient and builds in IPC as a fundamental, low-latency operation.
Homeless shelters here are terrible TBH. I’d rather sleep rough. Living in a van for me is better than a house or apartment because:
- no rent, no mortgage
- no noisy neighbors sans the phony-“tough,” backwards-hat teenager act
- less space to fill it up whth $crap I don’t need
- always mobile
- able to leap tall buildings in a single bound
- dual burner stove and 20 kg propane tank
- all Burner, all the time
- no lawn to mow
- no bills but the basics
- it’s really quiet
- no neighbor from hell to gas you out smoking, using too much lighter-fluid and cooking with their BBQ right next to a fence below you and screaming/terrorizing/trying to intimidate everyone
- indoor nudist as long as I want
- volunteers of the blond varietal tested suspension for squeaks; needs more data
- able to monitor DIY blinker fluid meters closely