101 karma · joined May 21, 2015
https://www.gov.uk/government/collections/the-economics-of-b...
You have a point here, but what really is at stake here is tax-evasion, not reduction.
The company declares no profits in France (and thus pays no tax) because its profit is fraudulently passed as costs to pay for IP or services for the mother company in another country.
Also, consider the fact that tax evasion is a crime in most countries and that this is a very bland measure when compared to what these companies (and their executives) really reserve.
http://deic.uab.es/~iblanes/beamer_gallery/individual/Copenh...
I have a hunch on how they are doing this.
From the blog post it appears that the network is using angles and distances of aminoacids in a given sequence in know structures to predict good starting point(s) for regular molecular dynamics-based structural optimization (what is called the "gradient descent step" in the post).
If I'm wrong then I'll just have to try this approach myself one day...
Or the other way around...