imcoconut

> Every single thing in your post makes zero sense

Not true. Most of the post makes sense. Trustlessness and decentralization are pretty much the only benefits to bitcoin and others like it. There are obviously real costs for these features, but also real benefits. Do the benefits justify the current valuations - only the market can determine that. I personally am quite bearish on almost all cryptoassets (so I would not be considered a "pumper"), but certainly you must see the threat they pose to the incumbent masters of the monetary system?

only on HN.

Before the reaearch endeavor, the company had x more dollars in cash. They bore the cost with the expectation that it would generate cash flows in the future (to hopefully more than offset the cost). The dollar cost was likely quite large. So the company certainly would not be in the same position had they not decided to develop the drug. There was no cost the affected genetically blind, however. They only now have the option of potentially being able to get a new treatment.

It's a simular situation on the mac os. I remember reading a post here a little while back about some security flaw in the new mac os that allowed unauthorized access to root. The fact that i have to go through the process you deacribed evry day is very frustrating.

They push way to hard to be constantly updating os versions, especially given the serious bugs that people seem to be finding.

Could not agree with this more.

Transactions in bitcoin, eg sending a bitcoin from one wallet to another, occur on the blockchain and are decentralized. The fiat value of bitcoin, however, is determined by supply and demand for that bitcoin-fiat cross, just like anything else in open markets. That trading for these crosses occur on the exchanges.

> There's still a semi-central location you have to go to in order to get any real, actual currency out of it

This is definitely still the case. The exchanges themselves, though, could potentially be implemented via blockchain. This would likely reduce transaction costs and could make them more secure. In this case the would actually be decentralized.

This comment is extremely insightful and actionable. Thank you.

Welcome to hn :)

> Can't we just examine the existing literature and add our own thoughts without suggesting some grand "rewrite"?

Wow, i never considered this but it makes sense and i imagine is very effective.

Do you know of any well documented cases of this (though by its nature, any case of this is probably not well documented)?

This sounds more like a fault of the parents than of the society. "The Constructs of Society" seems like too vague a notion to be able to measure or determine its impact. A person may be dissuaded from pursuing something because "society" really is doing so, or because they perceive society is doing so. In some instances it's easy to determine which is the reason, in others I think it's more difficult.

At the end of the day, part of being a good adult and parent in 2017 is not just accepting whatever constructs * you feel "society" is shoving down your throat. Think critically to form your own principles and beliefs, and act on them (so long as they are within the bounds law). Obviously this is easier said than done, and also there are probably places on earth where this isn't feasible. But I feel that in most of the developed world it is.

* not you rayiner, I mean you third person (I'm not accusing you of being a bad adult/parent!)

are there any significant benefits over matplotlib?

same, has helped tremendously

Unless the business is a tech company selling enterprise software. If, as other commenters have mentioned, their software is subsumed by cheap or free open alternatives, that could be detrimental.

Do you have any thoughts on tezos [0], which claims to have a formally verifiable language for its blockchain contracts?

[0] https://www.tezos.com/

Could you elaborate on this? By "resolving the powers" do you mean magnitude of interacting forces? And by correct dimensions do you mean spatial dimensions?

Ray Peat addresses the science better than anyone I've read. He's a biology phd from University of Oregon with a specialization in biochemistry, physiology, and endocrinology. Many of his ideas are not the mainstream but everything he writes about is extensively researched and cited.

He has a number of articles on sugar but a good one to start with is Sugar Issues[0]. It can get a bit technical so I would recommend keeping wikipedia and google handy. It looks to have around 50-100 references for further investigation. Here's also one of his many radio interviews where he discuses sugar (starts in earnest with respect to sugar at around 14:35, but whole talk is great)[1].

Basically, sugars (glucose, fructose, sucrose, lactose) are healthy and protective for a wide variety of reasons - as long as they are able to be fully oxidized by the mitochondria, to produce carbon dioxide and a greater number of ATP. Many of the alleged "evils" of sugar are actually due to the polyunsaturated fats, which inhibit proper metabolism of sugar and damage cells in a variety of ways. One well established mechanism is by competing with glucose for oxidation, resulting in higher blood sugar levels. This is known as the Randall cycle (or glucose fatty acid cycle) and actually serves as the foundation for an as-of-yet unchallenged theory of type 2 diabetes.

I highly recommend reading ray peat, and listening to his interviews. His intelligence, recall, and ability to synthesize information to form coherent biological models across a variety of topics are all-together astounding. I honestly recommend all of his articles and interviews. It takes some time and re-readings to fully grasp the concepts he advances, but it is well worth it.

[0] http://raypeat.com/articles/articles/sugar-issues.shtml [1] https://www.youtube.com/watch?v=Lx96YYKvA9w

> as guilded the cage is, it's still a cage

Depends on the software. In general infrastructure has a much higher liability associated with it, as a failed bridge, road, or building, will quickly kill/injure those making use of it. I could see a similar situation arise for, say, embedded software for medical devices like pacemakers etc.

I remembr a discussion here recently regarding "p-hacking". With so many thousands of genes, aren't a fair number going to be correlated or predictive with statistical significance by sheer probability?

Aside from the fact that it is in their terms and doing so would violate said terms, I don't see the issue with google prioritizing their own properties over others.

Search is a feee service offered by a private company. Users of search don't pay for it so I dont see how monopoly or antitrust legal issues arise. As long as they are honest about what they're doing, and don't manipate ad results (which is a service that does have paying customers) the non ad results could be generated however google sees fit. Since it's free google should be able to set whatever terms it wants - if you don't like it don't use it. No?

This looks awesome.

Does anyone have any opinions on how this compares to pycharm for similar IDE functionality and jupyter support?

I was citing in case anyone reading was unaware of his mathematical chops.

That's a fair point. I'm not one for argument by authority.

My point with his discovery is that he's empirically demonstrated a capability of uncovering understanding and deep mathematical relationships, which have practical implications. The PHD part is less relevant.

In my opinion, this information decreases the probability that rentech has been consistently outperforming on the basis of pure luck. By how much, though, I can't say.

But if the person who called all 20 flips properly is a math PHD who discovered the Chern–Simons secondary characteristic classes of 3-manifolds which has had a profound effect on modern physics[0] - I might think they've figured out some deep shit about coin tossing.

[0]https://en.wikipedia.org/wiki/James_Harris_Simons#Academic_a...

I wish i could give 2 upvotes

Where?

Lol, sorry - well hopefully someone else reading this thread can find out about jupyter lab. it really is amazing.

Thanks so much for all your hard work!

The jupyter team has been working on jupyter lab which is a more r studio style environment. It incorperates notebooks, terminals, file editing, traditional ipython console, plus some other cool stuff in a web ide. You should be able to use an R jupyter kernel with it.

It's in alpha right now but they're making crazy fast progress on it. I've been using it and it's awesome

doing everything with dates makes more sense this way! :)

dask has been a real pleasure to work with.