joedevon

I'm gonna end the conversation here and let you have the last word, because I don't even feel comfortable talking about compounding pharmas.

From what I've read, sites like the above are really dangerous, because people are ordering from them and like you said, are NOT for human consumption.

Compound pharmacies, from what I understand, are meant for human consumption. From the healthcare people I know personally, including my own doctor, they have been used for ages and are totally legit. But folks should just talk to their doctor before taking anything.

I believe you.

Look, I read a bunch of contradictory stuff on the internet about this and am close to a good number of people in healthcare who told me compound pharmacies are legit and that there's a lot of FUD on the internet.

But I'm not pretending to be an expert in law or medicine.

People need to research this and do what they feel comfortable with.

That said, I'd personally prefer if the prices came down, the supply remained highly available and it was covered by insurance and the companies like Novo who spent money to create these solutions got paid for it. It's a miracle and they deserve what money they make off it.

Do some research into compound pharmacies as a worst picture backup. I know several people on them successfully. Peptides can't be patented. Semaglutide is a peptide. They are patenting the delivery mechanism AFAICT. As to sides, ramp up slowly. Maybe you won't have any. Also, there are new drugs coming that are even better. I'm sure the shortages and whatnot will be sorted out. The solution is out there. They can't stop this train.

Imagine being 250 lbs and feeling like you are starving constantly, despite eating a lot every day. You decide to lose weight. You do something you hate, like calorie restriction and working out like a dog. You lose 80 lbs in 1 year. Bravo. Everyone tells you how great you look. You feel great. All that hard work was worth it. The fatness and a million other things really motivated you to do the hard work. I've done this a couple of times.

Next day after hitting your goal, the starvation is still there. The desire to eat is still there. Hating working out is still there. But now you have to do this herculean effort every day not to get better. Not to lose weight. Just to maintain. Your brain wants you to gain 80 lbs and will never stop nagging you. Not on a good day. Not on a bad day.

Then something really shitty happens in your life. Like it does for everyone. You slip. Eventually you start to gain back the weight. You just want to die. You feel like a failure. You hate yourself.

That's the trick. Hitting goal weight the first time or two is relatively "easy". But you've achieved nothing if you aren't able to maintain weight loss. That's the failure of all approaches prior to these GLP1 and similar drugs.

Having set the scene, now compare it to semaglutide. You have a drug that regulates your brain. Gets rid of the constant nagging to eat. You get normal brain. You lose weight.

Now you have to pick, take a once a week drug for life to maintain, or do a herculean effort to fight the brain urges and work out to maintain.

Which do you think will be more successful?

Well said. I believe you are right. That and ignorance of how Leptin works, setpoint or lipostat theory of bodyweight regulation...once you've gotten fat, your setpoint goes up and the hunger signals are far greater than folks who have never gotten fat. You can have 2 athletes with identical weight height and BF%, but if one had been fat once, their hunger signals from the brain will be far greater than the athlete who was always slim.

that hurt. lol.

How about fine tuning testing w/ Davinci and then scaling it down for the other models or HF once you've proven it works. I believe the openai docs propose this approach (minus HF of course)

I'm skeptical as well though willing to listen.

Which public resources? I didn't see any references cited.

It's pretty common in the startup space to exaggerate, but even a reference to a studio's own stats would at least be a good start.

How much of the purchase price is a barter for Azure compute-time? That may explain a lot.

You can overcome the starvation response caused by the lipostat with willpower if that's your point. Not many do. In fact, there's a registry of such people http://www.nwcr.ws/ . They report having to be diligent every day. They work out every day. They watch their calories. They can't relax about it. That's why it's so hard to succeed in the long run.

You don't seem persuadable, nor too interested in the science of the lipostat, so I'll just let you have the last word here.

Oh really? Got any more info on that drug?

"What factors do you think are influencing your desire to eat more or less?"

There is a lipostat or setpoint in the hypothalamus. It acts like a thermostat for fat. Fat levels are controlled by a homeostatic system, just like body temperature. The highest amount of bodyfat you've had will typically be the bodyfat your brain will defend. It not only does this by making you hungry, it also will downregulate your metabolism. So you become less active. Anyone who has been obese, is fighting their own brain to maintain fat loss. Losing fat is easier than maintaining fat loss. Semaglutide disrupts this system.

BTW, the mechanism of the setpoint is Leptin, a hormone secreted by fat almost exclusively. Muscle also releases Leptin, but in small amounts.

So if you cut the fat out, if you use liposuction, or you diet down slowly, or you diet down quickly, it doesn't matter. Your brain still knows how much fat you have, based on the leptin signals it gets. You cannot trick it.

The reason bariatric surgery is effective is that cutting out the stomach reduces the amount of ghrelin released, which is a hunger hormone that the brain sends the body. Again, disrupting the homeostatic system...which is the only effective way out of this mess.

I was expecting more people on hacker news to know about homeostasis of fat by now. Leptin was discovered 27 years ago.

A former client of mine built a wonderful mobile app that actually calculates your bra size: https://www.wacoal-america.com/find-your-fit

TIL we can use seeds to create hu-mans. So cool!

I didn't trust it, but we tried https://hire.google.com/ because of this belief in GSuite products being stable. It was a great product. Had to move to Greenhouse.

I've been fascinated by FMT, but it also grosses me out. I'm super curious, was it tough mentally to take the pill if it was a pill?

I'm sure it was a mixed bag but Corporate Media did not break the Epstein story. They famously avoided it, @see Amy Robach and ABC News leak. The Miami Herald, a local paper, broke the story thanks to a great journalist there.

IMO you are really discounting just how massive the importance of local journalism has historically been.

PE firms are now buying up and destroying these once great outlets, including the Miami Herald.

If you build digital products that serve millions or billions of people, you can scale kindness. One easy change is to spend a bit of time learning about accessibility and incorporating it into your work.

That comment gave me the biggest smile @eclipxe.

My brother and I had the Fairchild and we preferred it to the Atari, though we enjoyed both. We were sad when the games stopped coming out for Fairchild and Atari started getting all the attention. Thanks @nicole for bringing back memories.

Here's an example.

Journalist spends a year on a story. Puts it on her blog. Shares the post via a tweet. You love the story, appreciate the hard work and give a tip.

I often have used the microwave as a timer/alarm before switching that function to my phone.

underrated comment

problem solved! whew

My condolences :(

It probably doesn't even work without wifi hahaha. j/k (I hope). Remember the Juicero?

It would be even more interesting if they found C3PO IMO.

Since Pringles tastes like cardboard, why don't they start making the can out of Pringles?

Indeed. What if you are a super responsible person, but there is unrest in a Country you are visiting or live in, through no fault of your own and you are unable to pay a renewal. Or you fall sick and go to the hospital.

sure but I always love seeing people's book lists :)