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lsternlicht

262 karma · joined July 8, 2009

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lsternlicht··on Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)
No
lsternlicht··on Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
Phase 3 trial was stopped on a positive interim analysis by DSMB and in consultation with FDA

Interim analysis was performed on approximately half of the total enrolled patients (775 of the 1550).

Trial included many delta and other variant patients

—————

Efficacy

  • ~50% reduction in hospitalization (14.1% PBO vs 7.3% drug)

  • 100% reduction in deaths (8 PBO vs 0 drug)
—————

Safety

  • fewer adverse reactions in the drug arm vs PBO (40% PBO vs 35% drug)
—————

[Merck Ridgeback press release] https://www.businesswire.com/news/home/20211001005189/en/Mer...

[clinicaltrials.gov] https://clinicaltrials.gov/ct2/show/NCT04575597?term=molnupi...

lsternlicht··on Residual Value: Electric Batteries vs. Internal Combustion Engine Vehicles
This argument avoids the issue of battery depreciation as well as the fact that if you took the battery out of the car it's value goes to the scrap value.
lsternlicht··on HN Domain Exchange: Add your unused domains
I have hoot.com. Still haven't come up with a finalized idea for it.
lsternlicht··on So A Blogger Walks Into A Bar…
I think your statement was clear. However, I find it hard to believe Arrington would put some of his best sources at risk if his claims were completely unfounded.
lsternlicht··on Ask HN: Hacker Hobbies?
Can you give me an example of thinking critically and rationally vs thinking analytically?
lsternlicht··on Goldman executives cheered housing market's decline, newly released e-mails show
These articles have sensational headlines that don't point to the real issue. The possible fraud committed relates to GS recommending securities that they were betting against.
lsternlicht··on Oakland Cafe Owner's Banning Laptop Experiment
Sounds like Cafe Grumpy NYC
lsternlicht··on "Basically, It's Over" by Charlie Munger
Actually depending upon how the warrant is structured it's most likely a pseudo-derivative, not a pure play on pricing action.
lsternlicht··on Ask HN: Review my app: Search expired/available short domain names
This is very interesting. Where are you sourcing the data from?
lsternlicht··on Ask HN: Any startups looking for a free marketing guy?
shoot me an email - lsternlicht@gmail.com
lsternlicht··on [dead]
Great add jonmc12. This article might not appear relevant to HN, but the financial situation we are currently in will be looked back at like the robber barons of the 19th century.

It is startling that Paulson touts that $800 billion of tax payer dollars were needed to "free up the credit markets" and we find out they went right back to the casino.

Check this video out: http://bit.ly/4laL3d

lsternlicht··on How to Become a Design Genius: Take Time Off. Lots of It.
http://www.sagmeister.com/index.html ... makes me feel nauseous/dizzy
lsternlicht··on This is a pipe. (Something dear to me.)
^ mildweed is behind Tiny Sauce
lsternlicht··on The 2009 TechCrunch Web App Survey Results
Very difficult to believe (even rationalizing a success bias) that 60% are generating $1,000-$10,000 when 55% have costs of less than $1,000.
lsternlicht··on Ask HN: Do you create music? Let's hear it!
Trafficlight, this is some really good stuff you got going. Keep it up! Especially Topography of the Sun
lsternlicht··on Developing a Process for Visualizing the Insanity
Most of his articles are great examples of web design that greatly enhance a reader's experience. I think that the importance of good design is often overlooked. I've always admired the design of YC startups, which I believe has made for more enjoyable experiences. After all, design is one of the three things YC mentions.

"How do we choose who to fund? The people in your group are what matter most to us. We look for brains, motivation, and a sense of design. Experience is helpful but not critical."

lsternlicht··on [dead]
Am I seeing double? http://news.ycombinator.com/item?id=803902
lsternlicht··on How One Article Increased Sales 22% - From a small e-commerce owner
Thanks for the feedback. I agree with many of your points. The 18.3% was the click through rate from the article.
lsternlicht··on How One Article Increased Sales 22% - From a small e-commerce owner
@dcurtis is a professional. I'm an amateur.
lsternlicht··on How One Article Increased Sales 22% - From a small e-commerce owner
I was surprised by how much attention my last article got, so I want to encourage anyone who might be interested in writing their own to just do it.

The last article: http://news.ycombinator.com/item?id=723826

-Leo

lsternlicht··on Ask HN: Looking for feedback/recommendations - Hoot.com
Yeah, you do get the point. It allows people to endorse products so that other people can "window shop" what people like.
lsternlicht··on "you should follow me on twitter here" is annoying
“The bad artists imitate, the great artists steal.”

Picasso/Banksy

lsternlicht··on "you should follow me on twitter here" is annoying
I disagree. I think hacker news serves as a great platform for the community to benefit from what other members have found works. There are countless postings, whether they relate to CSS, analytics tactics, or tips like Dustin's "follow me on twitter here" that we all benefit from. I recently shared tips from my personal experience running a small e-commerce, and I hope some members get actual value and implement some of my findings. I thank and applaud Dustin for a great article and proudly utilize his findings. Keep sharing.
lsternlicht··on Tips from a Small E-Commerce Owner
I have not tried chat or click-to-call solutions, but they seem interesting. Depending on the pricing of the service and difficulty of implementation it might be worth it for us.

I have found that many articles talk about analyzing and optimizing cpc and cpm campaigns which is great for bigger sites with phenomenal traffic and online exposure. However, for small boutiques like Izola, I have found that these 3 tips have the highest value (income/time) ratio.

lsternlicht··on Monetize The Audience, Not The Content
Micro payments are the solution. There needs to be a third party micro payments company that acts as an "Open ID" for logging in. Then you could just pay $0.05 per article you read, or whatever the content provider chooses.
lsternlicht··on The Overconfident and Unrealistic Entrepreneur
Timr, I fully agree with you. However, what I wrote is not written for everyone. It was an opinion piece written for myself, and many in the same situation. I think that due to the ever changing nature of the internet technology industry, it is very hard for many to justify going after what their gut tells them. Because it is a lot more tangible to see and understand what you're working for when you choose to pursue a J.D. program or go into investment banking, my mind (and others I've spoken with) tends to ask "what if," during times of doubt. The times when I am most productive are times when I am working with a team and am really confident. If I could silence those reservations or "what ifs," I am positive that I would be more productive.
lsternlicht··on The Overconfident and Unrealistic Entrepreneur
Timr, my point was more about letting go of things that are inhibiting you from doing what you really want to do. This article is written for individuals that aren't able to give it their all because they are being influenced by societal pressures.
lsternlicht··on NYC MTA (mta.info) redesign
After being constantly reminded by trips on Metro-North, I decided to throw together a simpler UI. Thoughts?