mfld

    It is an attempt at recreating the lazydocker command-line application from scratch, while making it available as a web application without compromising on the features.

Wouldn't it be possible to directly use lazydocker with a browser terminal such as wetty?

Makes me think of Spotify

I don't get it. Ditching publishers to fund expert communities? Shouldn't there be some form of organisation that connects those experts, selects some as journal editors, provides infrastructure for submission/review/paper access, etc? If yes, wouldn't "publisher" be suitable term for such an organisation?

There exist publishers that, instead of being part of big media outlets, a run by research organizations themselves (e.g. EMBO press). I agree that it would be nice if more would be published there.

The SNPs can be found in the supplement, so you could check this. But why? Probably it would make more sense to check all risk alleles known to be associated with e.g. bipolar disorder to test for your own risk.

Thanks for that thoughtful comment. I particularly agree on the fragmentation of syntax: there are several syntax styles (plyR, S2 Vs S3, ...) and I always had a hard time figuring out the underlying data structures.

I think similar issues with syntax is what drove many students away from perl, preferring python with its one-way-to-do-it philosophy.

The improvement on predicting protein/RNA/ligand interactions might facilitate many commercially relevant use cases. I assume pharma and biotech will eagerly get in line to use this.

My three pain points with an M1 MBP and multiple displays are

- in some tools (like Emacs) the background can be mixed with blurred, outdated text from iTerm windows - after updates I must fiddle in the settings so that the windows are correctly focused when switching tabs - occasional "disconnected" screen that flickers black and might require to login again

While it's true that most of the tools for genomics are OSS, there is some good software and in particular some databases that are commercial and quite pricey.

And the sequencing machines and chemicals also don't come cheap, as the market has long been dominated by one vendor.

Yes, I remember putting "DNA sequencer" in the initial title for that reason

I would expect that you have a right to get your data deleted.

yTree would qualify: Small one-time fee, no subscription needed, simple but good results.

I have a 4 and getting it to 3 would take deliberate effort!

Thanks for the update, didn't know they were acquired by MyHeritage in 2019.

Yes, but the type of GWAS-based reports they offer not very well suited to uncover medical conditions like this.

But how can you successfully deliver food if a pizza doesn't fit in?

I assume it could be made more responsive by using a streaming text-to-speech synthesis like ElevenLabs Cheetah. This approach was taken by the RoboDad recently discussed on HN. Btw, is there a streaming text-to-speech tool that supports languages other than english?

AFAIK they do no longer rely on BGI for sequencing, but set-up their own facilities.

DNA has been extracted from Neanderthal bones more than 50.000 years old. DNA is very durable, for all practical purposes. I've heard some DNA synthesis vendors like Twist Biosciences will offer it commercially next year.

But why?

It is available at this price point for several years already. Due to the high price of consumables and other reasons, this is not practical for many applications, including sequencing your genome. One application where it shines is infectious disease monitoring in remote regions - it can run on the battery of the attached computer.

Nebula genomics, Dante Genomics, ySeq and others (waiting for deals might be needed). 23&me main offering does Not include sequencing.

Typst could be to LaTeX what Python was to Perl.

Time restricted eating/feeding is just a special case of intermittent fasting, no?

I believed that "more effective at loosing weight" would be self-evident in that context.

The intermittent fasting group adhered to the prescribed eating interval 6.1 days per week. In the calorie restriction group, 68 percent achieved the calorie reduction target over six months. The intermittent fasting group lost more weight, reducing body weight by an average of 3.56 percent in six months, which was significant. Under calorie restriction, body weight fell by an average of 1.78 percent, which was not significant.

Check out editGPT for an improved UI

Related question: is anyone happily using a walking pad or similar while coding?

You can release your DNA with an open (source) license. I personally would be hesitant, similar as I would not open source my fingerprints, health records etc., even if it is forbidden to abuse them.

But several consumer genetics companies do offer health reports. AFAIK it is perfectly allowed to turn insights from studies into personalized reports as long it is clear that this is not diagnostics or medical advice.

Sure , there are several big issues in compromised DNA profiles. See also: https://www.ecseq.com/blog/2019/privacy-implications-of-gene...

But let's wait until it's clear whether raw data was actually leaked.