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minthd

686 karma · joined November 4, 2014

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minthd··on Is the FDA Too Conservative or Too Aggressive? Analysis of Clinical Trial Design
Thanks. You really know this stuff.

Why is there dependence on drug companies ? distributing drugs bought in Europe or elsewhere is pretty easy.And as for drug companies being protected from american litigation - if they don't sell it on u.s. soil, they are not responsible in u.s. courts, right?

As for the process being complex and expensive, is there work being done to solving this, with regards to EMA approved drugs ?

minthd··on Is the FDA Too Conservative or Too Aggressive? Analysis of Clinical Trial Design
Is there any realistic possibility Americans could use drugs approved in Europe ?
minthd··on The Muen Separation Kernel
This relies on Intel's Vt-d , but there are some issues with Vt-d :

http://invisiblethingslab.com/resources/2011/Software%20Atta...

minthd··on Ask HN: Good short programming books
"Practical Object-Oriented Design in Ruby: An Agile Primer" is a really good book for learning object oriented design. Not sure how long - but it's worth it - and you don't really have to read the whole thing.
minthd··on Methods Videos Are Making Science Smarter
Could you do the same shootings yourselves ? how much time/complexity would it take ?
minthd··on FCC considering a proposal to lock down devices with a “modular wireless radio”
>>Because in some devices, to restrict the baseband from interfering, you also have to lock down the OS to the point where the user can’t modify it.

Can you please give an example ? also couldn't be solved by designing the correct API for the communications processor ?

minthd··on Uber hires two security researchers to improve car technology
The BMW scenario is interesting ,but:

1. Will ride sharing still be a thing with self-driving cars ? Because it could have a strong network effects.

2. Will consumers prefer the most tested vehicle, let's say - Google's ?

3. Are BMW fit to sell a commodity product more than others ?

minthd··on FCC considering a proposal to lock down devices with a “modular wireless radio”
Cached link:

http://webcache.googleusercontent.com/search?q=cache:0C9h0wa...

minthd··on Moving forward with work on the D language and foundation
>> D is an ample language that could be used for a large range (heh) of applications. I want to make sure the core language and libraries offers a solid support on which various applications, frameworks, and libraries can build.

The advice given in marketing new products is often opposite - find a niche, offer much better value than competitors for that niche ,become the leader of that niche - and use that base to expand.

I wonder if this kind of advice offers a better route for success for a programming language ? What was the case historically ?

minthd··on VR and the future of computing: awaiting its iPhone moment
>> These first devices will be the first real, functioning examples of consumer VR tech that doesn't totally suck, but they'll still be a bit bulky, often require a more powerful computing device to do the heavy lifting, and won't really be appealing outside of the enthusiast and early adopter space.

Looking at review videos of VR by regular people, it seems that the emotional experience it gives people is strong enough for them to live with compromises being made.

Of course there's a difference between that and paying $1500 , but maybe with mobile phone based VR we can bypass that , to an extent ?

minthd··on VR and the future of computing: awaiting its iPhone moment
>> iPhone was out for a year before it got any kind of apps going.

It took time to gather enough users to convince developers and the carrier to support your app store the way Apple like it.

minthd··on VR and the future of computing: awaiting its iPhone moment
Actually nokia had an iPhone like device in 2004(whatever that means, not a lot of details, understandably[1]) but: “It was very early days, and no one really knew anything about the touch screen’s potential,” he explained. “And it was an expensive device to produce, so there was more risk involved for Nokia. So management did the usual. They killed it.”

Apple faced a similar decision - an expensive device, that wasn't a sure success(at least in the beginning) - but they could leverage their iPod customers and their music libraries to get an initial market for the device - and than use that power together with a smart strategy(playing carriers against each other, which was hard for nokia) to fully control the phone - what enables a very different app store dynamic .

Couple that with Apple's deep understanding of brand building and marketing ,one gets the notion that nokia lost to the iPhone less because of not seeing the future, but more because Apple had better resources and skills and just played a better game.

And why did Apple lose to android ? due to the same reason - Google is far better at software development + Open source phone financed with ads fits Google very well.

[1]http://venturebeat.com/2010/09/27/nokia-had-iphone-like-prot...

minthd··on All evidence points to OOP being bullshit (2013)
What books will get you there?
minthd··on Apple Loses German Top Court Case on Swipe-to-Unlock Patent
>> If the AI can invent it, it is not worthy of a patent.

I'm not so sure.if you found some drug as the result of an high-throughput-screening by robots/ai - you would get a valid patent.

minthd··on Apple Loses German Top Court Case on Swipe-to-Unlock Patent
I think this should apply generally to touch screen gestures. Once someone invented a good enough touch screen display(capacitive) , the gestures are not that big of a step.

All Apple did was to acquire the inventors of the capacitive touch - and worked a bit on the UI. And while it's valuable to be the first company who recognize the importance of a capacitive touch screen - that isn't a basis for a patent - and Apple did get enough benefits anyway.

minthd··on As Coursera Evolves, Colleges Stay On and Investors Buy In
I often noticed that some books are phenomenal, and don't really have a mooc, but should definetly have something.

I wonder if there's a place for a site that:

1. Gathers recommendations the best book on a given subject + some set of practice material

2. Helps to forum study groups or classes, gives them forum/hangouts,etc,offer some structure, etc

3. Enables P2P grading by students

Basically ,helps as much as it's possibly can for students to form great classes around great books.

What do you guys think ?

minthd··on IBM’s School Could Fix Education and Tech’s Diversity Gap
>> possible for a person to learn this independently or on the job. In practice, that is sufficiently rare as to not be worth discussing.

Is this because people don't really feel a strong need to learn this, because they manage to find their next job ? or because it's impossible to learn alone(even with the help of mooc's and the like) ?

minthd··on Updates Make Windows 7 and 8 Spy on You Like Windows 10
Will games that run on Steam OS be compatible with regular linux ?
minthd··on Updates Make Windows 7 and 8 Spy on You Like Windows 10
IANAL , but:

" Unilateral modifications are not supposed to alter the material or important terms of the original contract. "

http://www.faircontracts.org/contract-provisions/unilateral-...

minthd··on Updates Make Windows 7 and 8 Spy on You Like Windows 10
:) .Is that even legal ?
minthd··on Updates Make Windows 7 and 8 Spy on You Like Windows 10
If that's true - doesn't this expose microsoft legally ? I mean we paid for win 7 under certain terms, and now they're changing them.
minthd··on MicroPython 1.4.5
Maybe there's a reason they implemented actors using extension ? performance/latency ?

Maybe you guys should collaborate with the guys behind the paper ? they can offer their expertise - and if they built it inside micropython, that means many more people will use the technology - and they will get much more academic citations.

minthd··on MicroPython 1.4.5
In that paper they added "a small set of extension"(3KB of code) to OWL[1]. Those extensions, together with a special hardware bridging mechanism enable using the actor model in an mcu context.

Why use the actor model ? because it brings, to event

[1]OWL seems pretty similar to micro python - but they started working on it before micro python was availble.

minthd··on MicroPython 1.4.5
For those interested in simplified embedded development , this[1] paper implemented a python like language on microcontrollers , that does include the actor model, and they show it enables higher abstraction(and reuse) in microcontroller systems - which are usually event driven.

[1]https://www.usenix.org/system/files/conference/atc14/atc14-p...

minthd··on Ask HN: Open Source projects an intermediate python programmer can contribute to?
https://openhatch.org
minthd··on Uber Plans to Go Public in 18-24 Months, According to Leaked Presentation
You're forgetting ride sharing(i.e. uber's UberPool). by sharing rides , one can save 40% (or maybe more, inc case sharign with 3 passenger is available) of cost. And that creates a powerful network effect with the possibility of disrupting the private car.

Since this lower cost sharing dynamic might be appealing to passengers also in a world with self-driving cars, and such network effects would be a powerful effect against commodization for the self-driving car company - it's understandable why the SDC company might be willing to share profits with UBER , just to lock the market.

Of course that's one scenario, but in general, one would guess that UberPool will have some influence on the self driving car market.

minthd··on Exploiting Domain-Specific Knowledge: Spiral [pdf]
not that i know of.
minthd··on China factory activity shrinks to six and a half year low as orders tumble
There are many markets where branding isn't a big deal,like b2b, And China is becoming a better competitor there. For example, they lead the world in modular high-rise construction which could be worth a lot one day. They are also very good at building infrastructure.

As for consumer products, xiaomi plans to be in hundreds of product categories, maybe they'll succeed.

minthd··on Announcing the D-Wave 2X Quantum Computer
At least, getting access to some pretty programmed algorithm running on a it on a cloud should be easy enough to do.
minthd··on With $100M in Funding, Carbon3D Will Make 3D Manufacturing a Reality
3d printing of injection molds is already being used for some low volume medical products.
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