mylons

haha. hubris thy name is tzumby.

look up what isaac asimov had to say about genomic analysis.

the entitlement people have towards free, open source software, is incredible.

this isn’t even a “new” problem. if you were around in the early 00s or before you probably worked with a BOfH sys admin that didn’t let you update system packages. that person cared deeply about system integrity and enforced it with policies around package managers.

having outsourced all of that stuff over the years to the cloud, it seems like people forgot this reality existed and can still exist.

the mob freak out is really a projection of a skill issue and it’s sad.

what a fascinating take. i just scrolled the github thread. there’s very little, if any substance.

your perception must be very interesting to have gleaned anything but seething AI rage.

github hasn't absorbed agentic coding, though. agentic coding has absorbed it, and as a result it's quality is suffering.

the thing about github that is so maddening is linus gave us the secret with git itself. then we reinvented centralized source control using git and called it github, and here we are.

my father made reading The Agony and The Ecstasy a requirement to go to Italy when I was a sophomore in high school. It's a thick tome, but a great read if you're a curious kid.

as the others said Michelangelo hated doing that painting. He's a very tragic, albeit heroic to me, man. I'd recommend that book if you're at all fascinated by him.

last.fm was so promising when it came out but i have to say i didn’t discover anything using their platform.

chatGPT is incredible, just giving it a single song and some context, it can recommend at a rate of something like 85-90%.

the only place i’ve gotten the BEST music recommendations were the oink and last.fm forums. humans, still, are the best recommendation infrastructure.

i love you guys.

haha — this is the exact comment i was hoping to see! indeed, i was joking. The Watchmen graphic novel is very important to me as it opened my eyes to the concept of “who watches the watchmen” which I was ultimately eluding to here, albeit extremely facetiously.

This is GOLD Jerry, Gold.

but who detects the down detector detecting the down detector detecting the down detector

iran did this to themselves. any other view is simply insane.

they’ll easily make this up at the parks at the new tron ares ride

are you dabbling at all in the “no build js” stuff that Rails 8 supports? i did it for that corporate project and their deploy time went from 30 minutes to 5 minutes. it’s also such a headache reliever but removing most of the confusing aspects of the JS ecosystem for me.

i came back to rails after a very long hiatus to help a company bring a 10+ year old rails project to Rails 8.x.x from Rails 5. It took a bit to get back in the saddle, but every new project I’ve started since that’s a SaaS/CRUD app of some kind it’s in Rails.

I’m finally at the age where productivity is infinitely more important than anything else.

fwiw Heng Li was "the author." He was a postdoc under Durbin's professorship. I was around when bwa was developed and was working in a collaboration with Heng Li (I was working on SOLiD R&D). Any development emails were between Heng and our team, we never spoke with Durbin.

first author on a paper like this indicates the most significant contributions https://academic.oup.com/bioinformatics/article/25/14/1754/2...

this is also the insight that the bwa developer had, to use the burrows-wheeler transform which is part of bzip2 due to it's compression properties being particularly good for genomic sequences.

money is a proxy for value. the post i was responding to seemed to be pointing out how little value there is in something else.

sure, but instagram was created by a handful of people with python and got a billion dollar exit in 2012.

also text UIs have always attempted a sense of flashiness? your BIOS, DOS UI's back in the day, etc. the OP sounds oddly jaded by it for no particular reason?

ya it's pretty FUCKED UP that HAMAS does that, and Iran funds it, isn't it? or do you think Israel just wants to slaughter people weaker than them because they can? if that was their aim why did they wait until 10/8 to start doing it? they could have done it any time in the last 30 years.

to say that is what is happening is completely disingenuous. seemingly something happened by the democratically elected government of Gaza on 10/7

is the destruction of gaza awful? yes. is it a genoicde? no. flippantly tossing words around devalues them and debases the conversation. https://worldpopulationreview.com/cities/palestine/gaza

the 20 years leading up to trump, calling every republican a nazi, has completely destroyed the meaning of the word. trump is actually doing a lot of fascist leaning stuff this time around, and you could possibly use that word appropriately but it is currently meaningless.

google gives you access to real SEO blog spam. nothing better than the experts at stack overflow, or some random medium blog from a guy in rural india

that is true, but he _has_ been slashing and cutting government programs. i think you're right and it's just his personal agenda coinciding with this, but the overall hypocrisy is just wild to me. not sure how anyone who voted for Trump can rationalize stuff like this.

big government is bad. therefore we should have government run journals. i imagine there's zero history to look at ([C]CCP) for evidence to why this is bad.

it's quite possible many model producers are trying to do this with telegram, and therefore there is a price for exclusivity?

what would you pay for this service? how quickly would you want the data? what format do you want the data in?

ok?

as far as i know there just isn't demand for one's own data like this. people have kinda tried, there's some weird web3 offerings that allegedly do this so you can monetize your data but afaik nobody uses that.

i mentioned in an earlier comment i'd be happy to start this company if there were that kinda demand. it'd cost you around $1000 USD to get this done and get a hard drive mailed to you with raw data (fastq files).

EDIT: it probably would be cool if this kind of thing existed so consumers could shop their analysis around. it might actually open up some consumer bioinformatics startups

as far as i know this is not offered. my assumption is there's little to no demand. if there is a ton of demand, i'd be happy to start this company :)

what do you mean? i think you more or less described every personal genetics testing company as they start out. they use the illumina machine to do the testing and develop custom assays with said machine