Yes.
553 karma · joined June 10, 2025
Here’s how it went down in the dune universe (I’m certainly messing up some details, but these are the broad strokes):
Humanity has spread to the stars. No FTL involved, just good old fashioned sublight engines. The dune universe takes place about 50-60,000 years in our future. Mankind has spread across a couple dozen solar systems and everything is going peachy. However, mankind gets complacent, fat, and happy with their success and society stagnates. A handful of eager, ambitious humans scheme about how they can take it all over. They do, and then eventually start turning themselves into cyborgs, or disembodies brains in a jars that swap bodies and are effectively immortal. One of the cyborgs gets lazy and makes an AI to manage things, which promptly takes over, overthrows the cyborg rulers of humanity, makes the cyborgs it’s slaves (who have great autonomy/are conspirators) and generally rules over everything. A small group of solar systems is left under human control, who fall back to a feudal-ish type system of government with lords and dukes and whatnot.
The AI does all sorts of nasty shit to the humans in it’s dominion. Unit 931 and Auschwitz type experiences, slavery until death, etc. Untold billions, if not trillions, of humans live in animal-like conditons worked to death. The human group of systems isn’t cool with this, but they can’t do much and are vastly overpowered by the cyborgs, so a fragile peace is held. One day, the son of one of the subservient cyborgs knocks up a human slave, and they have a kid. In the background, all sorts of rabble rousing and shenanigans are being done to stir unrest amoungst the slaves by the free human system. The human systems develop FTL, with spice as a catalyst, except it doesn’t work 10% of the time and kills the pilots. The AI’s main henchman (who does all of the nazi and Unit 931-type experiments) decides it would be cool to kill the baby of the cyborg son and the slave. The slaves last name was “Butler”/ This sparks a massive revolt by the slave worlds. The free human systems then go on to fight a prolonged war against the machines, using the FTL drive at great loss of life, to begin a “Butlarian jihad” to free the humans from thinking machines. Lots of other stuff happens, and humanity eventually wins, but this is why machines no more advanced than a desktop machine are allowed in the dune universe, and why they technologically hobble themselves.
>Anduril lands $2.9 billion Navy submarine shipyard contract days after Founder joins Pentagon weapons group[1]
{1}https://www.msn.com/en-us/money/general/anduril-lands-2-9-bi...
“We went to the hospital together and I remember him saying, ‘I’ll go first so you’re feeling at ease,’” Vandenkerckhove told VTM.
Good on the dad for not trying to weasel out on this and stepping up.
https://en.wikipedia.org/wiki/Wikipedia:Administrators'_noti...
How is training my replacement on a plagiarism machine that is actively putting people (including myself) out of the job while destroying the environment (but whose results are still not as good as a human) in any world a good thing?
There is no boost in productivity for non-tech related stuff. If you need to double-check the output, it is de facto not as productive as a human, since you need to effectively do the work twice.
Also, it adds nothing of value where is is being crammed into everything, and just seems to be a cynical techbro PE driven buzzword play.
Thing is, GameStop is, well, for videogames and videogame paraphernalia. It's not a general store. Doing this would turn them into a thrift shop, not a pawn shop, as people are trying to offload their carpets, desks, etc - bulky stuff.
I don't think this makes sense.
This does make sense when you consider the collectable market, another domain I'm involved in. Trading card games, specifically pokemon, have exploded over the last 5 years. GameStop is making a killing off of buying, selling, and grading these cards. Ebay is the primary marketplace to buy and sell those cards. There's also tax free havens ("Vaults") offered by multiple companies, grading service passthroughs, and scalping offered through ebay too.
Viewed through the above lens, that's what's prompting this offer, I think.
You would be astonished at how little it takes to bribe, I mean donate, to a politician for example. For as little as $10-20k USD you can get a literal seat at a table with a sitting senator or congresscritter for several hours at a "charity" dinner, with results as expected.
We do not understand these ecosystems beyond their extreme fragility and low entropy conditions. This is an incredibly destructive and expensive manner of resource extraction that destroys the seabed. Why would anyone sane ever support this beyond, I don't know, someone who also thinks that clearcutting the amazon is a good idea? What kind of vested interest do you have in this blighted technology?
This drug has been used in a huge number of patients for more than 11 years; the next gen of drugs is currently being used. I'm sorry for my curt style of writing, but - people like your father have helped pave the way for that next generation of drugs by constraining clinical trial designs.
Several things trigger my bullshit meter. Quote:
"This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"
PD-L1 monoclonal antibodies are only effective against cancers that are, you guessed it, PD-L1 positive. At high percentages, ranging from 1 to 50%. Are these authors even familiar with the state of the art when it comes to cancer medications? Mouse tumors do not equate to people tumors. Many tumor types are not PD-l1 positive.
Doxy is an ancient SOC chemo.
This is a nothing burger.
Give me phase II/III clinical trials, and then let me know what their PFS/OS was after 5 years. and what the medians were at 3- and 5-years. Also, ORR and CR and needed.
CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.
Shouldn't be too bad; USGS forecasts up to 1 meter tsunami.
While I applaud the use of alternatives to windows and it's apps, universities teach it because it is what their graduates will use in the real world. Governments use it because while it has it's flaws, it mostly works and is a universal standard. It's the toyota of operating systems. The parts and manpower to repair it and use it are available everywhere, and it's cheap and reliable.
> "This latest project will use locally available natural sand, held in a container 14m high and 15m wide."
-"a SBH could be artificially created by firing a huge number of gamma rays from a spherically converging laser. The idea is to pack so much energy into such a small space that a BH will form."