322 karma · joined September 12, 2011
But that is not always the case. The textbook example is sickle cell anemia: although it is very harmful in homozygous individuals, it confers resistance to malaria without negative side effects in heterozygous individuals, which is beneficial.
There's the possibility that a harmful gene today becomes beneficial in the indeterminate future, for a reason that we cannot predict. That is the logic behind genetic diversity in a species, which allows it to cope with new and unpredictable environments by essentially allowing alleles to compete in the "natural marketplace."
If we're going to take control of our genomes and select for ourselves which alleles are harmful or beneficial, we must at least be prepared to preserve genetic diversity, if not in living individuals, then in gene banks or genomic databases.
The relevant part is on p. 210: "In particular, the potassium channel of the Hodgkin-Huxley model should be identified as a first-order time-invariant voltage-controlled memristive one-port and the sodium channel should be identified as a second-order time-invariant voltage-controlled memristive one-port."
[1] http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1454361...
One of the relevant papers you can find on google is: http://symposium.cshlp.org/content/40/619.full.pdf
The author's suggestion:
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{Henny+Penny We can use google fonts anywhere if we just import them first with the google-font code}
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Dunno if there's a preprint somewhere.
[1] http://econometricsense.blogspot.com/2011/03/copula-function...
After an appropriate transport period, the brain is
perfused, sectioned, suitably stained, and each section
digitally imaged. These 2-D images are co-registered into a
3-D computer stack that is subsequently registered to a
common reference atlas. The resulting 3-D brain image is
largely unlabeled (i.e., contains no signal of interest),
except for the connections between the injected region and
its target regions. Thus the labeled connections are
clearly identifiable. A given region is injected in
multiple animals to account for individual variability.
[1] http://brainarchitecture.org/mouse/documentation/project-whi...
I've been having success with Go for backend work, and easy C integration in this kind of database like this would be useful for what I do. I'm not sure if R integration should be a priority though, since most R users I know are ambivalent about it (whatever, small sample size), and because Julia development continues to improve.
http://en.wikipedia.org/wiki/Kangbashi_New_Area
Ordos City itself apparently has close to 2 million people, but there's a fully developed urban housing district designed for 300,000 which has only reached 10% occupancy since 2010.
Sounds almost like "lean malware" written by a relatively small team using easily available tools and libraries.
[1] patio11: http://www.kalzumeus.com/
Google had taken ill.
The problem was the index storing the contents of the web
in Google's servers. For a couple of months in early 2000,
it wasn't updating at all. Millions of documents created
during that period weren't being being collected. As far as
the Google search engine was concerned, they didn't exist.
http://tazod.com/