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pmags

2,147 karma · joined March 11, 2015

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pmags··on US Science Agency NIH Says It Will Cut Funding to Researchers Who Protest Israel
The policy in question is awful, but NIH grants are awarded to institutions NOT individuals, so the "discriminatory prohibited boycott" clause likely does not apply to individual investigators.

Of course, the current administration has shown quite a disregard for the rule of law to date, so I wouldn't put it past them to change the rule or apply the rule inappropriately to punish individuals who are critical of policy.

pmags··on US to phase out many synthetic food dyes, Kennedy and FDA head say
Or no real knowledge of medicine, and bans something like vaccines. That hypothetical would be scary!
pmags··on Ancient DNA poses puzzle of why Phoenicians spread culture but not their genes
The article discussed in the commentary:

Ringbauer, H., Salman-Minkov, A., Regev, D. et al. Punic people were genetically diverse with almost no Levantine ancestors. Nature (2025). https://doi.org/10.1038/s41586-025-08913-3

pmags··on What to Read to Wrap Your Head Around the Climate Crisis
Earthday related recommendations.
pmags··on Table: NSF Grant Terminations in 2025
Some synthesis and broader context here:

https://www.nytimes.com/2025/04/22/science/trump-national-sc...

pmags··on European Neolithic farmers interbred their pigs with wild boar
This is a nice commentary on a paper that examines the process of pig domestication during the early neolithic period, as human populations in Europe shifted from hunter-gatherer focused societies to farming.

The paper referenced:

    J.A.M. Erven, V. Mattiangeli, M. Dreshaj, V.E. Mullin, C. Rossi, K.G. Daly, I. Jackson, M. Parker Pearson, D.G. Bradley, L.A.F. Frantz, O. Madsen, D. Raemaekers, & C. Çakirlar, 
Archaeogenomic insights into commensalism and regional variation in pig management in Neolithic northwest Europe, Proc. Natl. Acad. Sci. U.S.A. 122 (12) e2410235122, https://doi.org/10.1073/pnas.2410235122 (2025).
pmags··on Invasion of the 'Journal Snatchers'
Full title-- Invasion of the ‘journal snatchers’: the firms that buy science publications and turn them rogue
pmags··on A Call for Constructive Engagement
This is a joint statement from 187 university presidents / leaders in education from across the country.

More analysis here: https://www.nytimes.com/2025/04/22/us/politics/university-le...

pmags··on Deepseek Unmasked [pdf]
Here's the full membership of the committee:

https://selectcommitteeontheccp.house.gov/members

pmags··on The Government's Chemical Disaster Tracking Tool Just Went Dark
This is especially interesting in light of the following:

• Trump Laid Off Nearly All the Federal Workers Who Investigate Firefighter Deaths -- https://www.propublica.org/article/trump-cuts-firefighter-de...

> National Institute for Occupational Safety and Health, will also halt a first-of-its-kind study of the causes of thousands of firefighters’ cancer cases.

pmags··on NASA's Next Major Space Telescope Is Ready to Launch. Trump Wants to Kill It
Here's a related prior discussion of proposed cuts at NASA:

https://news.ycombinator.com/item?id=43653605

The proposed cuts, if enacted, will devestate scientific research at NASA (50% cut to science programs).

pmags··on One Bag: The Art and Science of Packing Light
Not at all -- there's no need to pack every single item into a bundle.

For me at least, the "bundle" is basically all the clothing that will be used at my destination.

Like any other packing situation, you'd keep a jacket, sweater, headphones, etc. outside of the bundle for easy access en route.

pmags··on US FDA suspends milk quality tests
Suspending milk quality testing at this time is particularly shocking given the H5N1 outbreak in dairy herds:

https://www.aphis.usda.gov/livestock-poultry-disease/avian/a...

• Choose "Total Outbreak" in the site above to see the full breakdown across states

The USDA's own website has the following headline text:

"Testing for HPAI H5N1 is crucial to achieve disease freedom from this virus in U.S. dairy cattle. USDA works closely with Federal, State, and industry partners to ensure our testing activities are comprehensive. "

https://www.aphis.usda.gov/livestock-poultry-disease/avian/a...

I guess the USDA and FDA are failing to communicate with each other.

pmags··on One Bag: The Art and Science of Packing Light
But that's the beauty of the "bundle method" -- no wrinkles!
pmags··on Anti-Vaxxers Are Grifting Off the Measles Outbreak and Claim Bioweapon Caused It
Particularly interesting since we have evidence of one of the grifters (Ben Edwards) exposing kids to it directly due to continuing to work when he had an obvious infection himself:

https://apnews.com/article/texas-measles-outbreak-rfk-jr-ben...

pmags··on [dead]
Here are some other facets of the new glorious new MAGA/MAHA "vision" at NIH:

• NIH bans all future grants to universities with DEI programs or Israel boycotts -- https://www.statnews.com/2025/04/21/trump-nih-grants-draft-r...

• NIH freezes funds to Harvard and four other universities, but can't tell them -- https://www.science.org/content/article/nih-freezes-funds-ha...

pmags··on Nature analysis signals the beginnings of a US science brain drain
Here are several related articles on US based scientists looking elsewhere:

https://www.reuters.com/world/scientists-us-harried-by-trump...

https://www.seattletimes.com/business/more-americans-are-eye...

pmags··on US FDA suspends milk quality tests
This goes along with plans to end other routine food safety inspections:

https://www.cbsnews.com/news/fda-food-safety-inspections-pla...

pmags··on One Bag: The Art and Science of Packing Light
One Bag is one of the remnants of the "old web" that continues to be updated and relevant.

Having run across it ~20 years ago, I still use their recommended "bundle wrapping" (https://www.onebag.com/pack.html) technique when I need to pack efficiently.

pmags··on The Rise of Luxury Doomsday Prepping
See also:

https://www.nytimes.com/interactive/2025/04/10/magazine/bunk...

pmags··on [dead]
An unparalleled attempt to amass sensitive medical data for millions of Americans, done at a breakneck pace to meet unrealistic deadlines decided on by an HHS secretary with no qualifications in medicine or science.

The current administrations security track record to date is less than stellar, as evidenced by recent DoD/Pentagon lapses. It's hard to have any confidence that a rushed job from HHS will be any better implemented.

pmags··on [dead]
This one speaks for itself. Quoting from the bill:

"A bill for an act relating to public safety; designating mRNA injections and products as weapons of mass destruction; prohibiting mRNA injections and products; proposing coding for new law in Minnesota Statutes, chapter 609."

pmags··on Martin Schwartz and the importance of stupidity in science [audio]
Martin Schwart'z original article:

Schwartz MA. The importance of stupidity in scientific research. J Cell Sci. 2008 Jun 1;121(11):1771. doi: 10.1242/jcs.033340. PMID: 18492790. -- https://journals.biologists.com/jcs/article/121/11/1771/3003...

pmags··on [dead]
If you'd like to read the directive yourself, see:

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-0...

pmags··on The End of Disease
As it relates to biomedicine, the AI community is increasingly toeing the "snake oil" line.

Yes, machine learning/AI is powerful, but pie in the sky predictions such as the "end of disease" probably hurt more than help in the long run.

pmags··on [dead]
The market uptick after the "pause" in tariffs was announced has been almost completely erased.

Trump can seem to help himself with respect to making pronouncements / fueling speculation that inevitably drives the markets down.

pmags··on Hegseth Said to Have Shared Attack Details in Second Signal Chat
What is this, "Opsec for Dummies"?
pmags··on One Simple Hack to Ruin Your Easter
Hope you enjoy your visit from the Easter Spudsy...
pmags··on DOJ Sends Intimidating Letters to Medical Journals for Supposedly Being Partisan
• https://www.medpagetoday.com/special-reports/exclusives/1151...

The actual letter (link included in article above)

-- https://www.documentcloud.org/documents/25900701-chest-doj-l...

pmags··on High time to tackle drug-resistant fungal infections
I agree that there is still a lot we can do to combat fungal disease.

However, your points 1, 2, and 4 unfortunately don't apply well to anti-fungals.

* "There is limited evidence that farming use of [anti-fungals] is what drives resistance in clinical cases."

Certainly not the case with respect to azoles:

-- Rhodes J, et al. Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment. Nat Microbiol. 2022 May;7(5):663-674. doi: 10.1038/s41564-022-01091-2. Epub 2022 Apr 25. Erratum in: Nat Microbiol. 2022 Nov;7(11):1944. doi: 10.1038/s41564-022-01160-6. PMID: 35469019; PMCID: PMC9064804. https://pubmed.ncbi.nlm.nih.gov/35469019/

-- Celia-Sanchez BN, Mangum B, Gómez Londoño LF, Wang C, Shuman B, Brewer MT, Momany M. Pan-azole- and multi-fungicide-resistant Aspergillus fumigatus is widespread in the United States. Appl Environ Microbiol. 2024 Apr 17;90(4):e0178223. doi: 10.1128/aem.01782-23. Epub 2024 Apr 1. PMID: 38557086; PMCID: PMC11022549.

-- Impact of the use of azole fungicides, other than as human medicines, on the development of azole‐resistant Aspergillus spp. https://www.efsa.europa.eu/en/efsajournal/pub/9200

"* There is no reason to believe we've hit a wall and can't invent more antibiotics in the future. "

-- There are very few anti-fungals, because fungi, being eukaryotes, have cell biology so close to ours. The "big three" are 1) azoles (lots of resistance; see above); 2) echinocandins; and 3) amphotericin B (highly toxic to the host)

-- One bright spot is a new antifungal published a few weeks ago in Nature, called Mandimycin: https://www.nature.com/articles/d41586-025-00801-0

* "There are still some antimicrobial treatment techniques we haven't put a lot of resources in. Like, bacteriophage treatments, or cycling antibiotics."

-- Bacteriophage don't work on fungi. Some degree of cycling and combination anti-fungal treatment are already in use.

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