wat? Anchorhead took me an evening to complete.
-2 karma · joined December 10, 2014
As others here have already suggested, I would agree that not signing the given contract and just going forward is not the right approach if you truly want to avoid the non-compete trap. Instead, amend the contract (or have a new contract drafted, as also mentioned earlier) and return it signed; it shows both your commitment to the work, and your attention to detail. The ball is then in their court. YOU now possess an amended, signed and dated copy of THEIR contract, returned to them along with an advisory of amendment.
> This barely scratches the surface. This process, along with others that modify how DNA is folded, brings certain genes closer together (while moving others farther apart), increasing (or decreasing) the likelihood of all sorts of first, second, and third order (...) interactions between them and their products.
> And we've only just begun...
Horribly vague, care to elaborate mathematically or at least provide some study links? The 'DNA folding' you propose begs resolution from some study using quaternions or attractors, or ... ?
Maybe, but what is really causing the DNA methylation? The article pins it mostly on epigenetics or environment, the 'stress of space travel', including dietary constraints and oxygen levels all of which are valid.
- https://theconversation.com/epigenetics-can-stress-really-ch...
- http://sitn.hms.harvard.edu/flash/2017/stress-induced-dna-mo...
- https://www.scientificamerican.com/page/sponsored/nestle/how... ooh, sponsored article, didn't catch that the first time.
However, the CNN article only briefly mentions 'radiation' as a factor and likely is lumping that into the 'stressful environment' case repeated several times.
Realistically, cosmic rays or radiation are far more likely to the be prevailing indicator for DNA disruption but are not plainly disclosed here. Despite much research having been done on this specific topic.
Wikipedia states: https://en.wikipedia.org/wiki/Health_threat_from_cosmic_rays "The potential acute and chronic health effects of space radiation, as with other ionizing radiation exposures, involve both direct damage to DNA, indirect effects due to generation of reactive oxygen species, and changes to the biochemistry of cells and tissues, which can alter gene transcription and the tissue microenvironment along with producing DNA mutations."
From this paper: https://arxiv.org/abs/1406.6641 "In the present paper, we suggest the BNR as a cause of genetic “fails” in living cells, that is one of the possible origins of the so called spontaneous mutations. Cells exposed to the shower of electrons and ions, caused by the collision of a neutron and a proton of water, could be annihilated or experience a permanent damage, in particular, a damage in the DNA."
Cosmic radiation detrimental effects to DNA confirmed by NASA in this study: https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/200800...
And more poignantly, from https://www.vencoreweather.com/blog/2017/6/26/1200-pm-cosmic... ( do not read full link if you are easily panicked ): "... there are other consequences of increasing cosmic rays according to “Spaceweather.com” including the penetration of commercial airlines, dosing passengers and flight crews enough that pilots are classified as occupational radiation workers. [Dose rates are expressed as multiples of sea level. For instance, we see that boarding a plane that flies at 25,000 feet exposes passengers to dose rates ~10x higher than sea level. At 40,000 feet, the multiplier is closer to 50x]"
Sorry for the data dump, I just happened to be researching cosmic ray effects the past few evenings and have collected many interesting facts on the topic. The most I have concluded at this point is that humans, as currently derived, are not made for space travel.
- https://theconversation.com/epigenetics-can-stress-really-ch...
- http://sitn.hms.harvard.edu/flash/2017/stress-induced-dna-mo...
- https://www.scientificamerican.com/page/sponsored/nestle/how... ooh, sponsored article, didn't catch that the first time.
However, the CNN article only briefly mentions 'radiation' as a factor and likely is lumping that into the 'stressful environment' case repeated several times.
Realistically, cosmic rays or radiation are far more likely to the be prevailing indicator for DNA disruption but are not plainly disclosed here. Despite much research having been done on this specific topic.
Wikipedia states: https://en.wikipedia.org/wiki/Health_threat_from_cosmic_rays "The potential acute and chronic health effects of space radiation, as with other ionizing radiation exposures, involve both direct damage to DNA, indirect effects due to generation of reactive oxygen species, and changes to the biochemistry of cells and tissues, which can alter gene transcription and the tissue microenvironment along with producing DNA mutations."
From this paper: https://arxiv.org/abs/1406.6641 "In the present paper, we suggest the BNR as a cause of genetic “fails” in living cells, that is one of the possible origins of the so called spontaneous mutations. Cells exposed to the shower of electrons and ions, caused by the collision of a neutron and a proton of water, could be annihilated or experience a permanent damage, in particular, a damage in the DNA."
Cosmic radiation detrimental effects to DNA confirmed by NASA in this study: https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/200800...
And more poignantly, from https://www.vencoreweather.com/blog/2017/6/26/1200-pm-cosmic... ( do not read full link if you are easily panicked ): "... there are other consequences of increasing cosmic rays according to “Spaceweather.com” including the penetration of commercial airlines, dosing passengers and flight crews enough that pilots are classified as occupational radiation workers. [Dose rates are expressed as multiples of sea level. For instance, we see that boarding a plane that flies at 25,000 feet exposes passengers to dose rates ~10x higher than sea level. At 40,000 feet, the multiplier is closer to 50x]"
Sorry for the data dump, I just happened to be researching cosmic ray effects the past few evenings and have collected many interesting facts on the topic. The most I have concluded at this point is that humans, as currently derived, are not made for space travel.
Well played with project... and the I'm sorry page title.
pretty sure my project and QA mgrs would not go for that on any given Sunday.
My biggest gripe of visiting TPB in the past 6 or so years is just this: the inane, mostly porno, sometimes gamer-centric adverts. I don't use adbblock or whatever because I don't need to in 99.999% of my yearly transactions. But seriously wtf is up with the ads on tpb? I can only assume these are the only ad providers that are willing to work with them, which kinda makes sense but also sucks for legit users.
I wonder about the passive implication the writer presents here, that the persistent targeting and raids are related to their public relations and advert content.