1,464 karma · joined July 12, 2019
researcher, IGDORE-affiliate
Advisor: BiosafetyNow https://biosafetynow.org/
Engineer, meet business school.
For everything else, there’s Astracard
In this framing what are the factions? What does geographically sorting mean - are the factions moving themselves from place to place?
We shall not be surprised that Jeffrey Epstein was exploring remaking this show https://www.justice.gov/epstein (search 'ufo')
We don't even know if Miller or Urey themselves would have (or did) frame their results that way. The honest framing is 'hey this is one way to form amino acids, and maybe that pathway is reflective of the origin of life, but that supposition remains conjecture on our part.'
The clutter is there yes - it's not a sparse 1970s kitsch cultural event promo or 1970s sci-fi book cover (random example I found in 2 minutes https://www.etsy.com/listing/715136429/david-bowie-moonage-d... ) that's for sure - but I wouldn't want to remove any of mine's elements as each one informs the viewer at a glance their decision whether to attend or not.
https://x.com/hilbertspaess/status/2099954626040905834
(Coxon)
>with settings, tools, and context
call me crazy, but I think that this kind of suite, which training-uber-alles people generally dismiss as trivially replicable ‘wrapper’ is actually the differentiating factor for LLM adoption today and moreso into the future.
I’m not dismissing the near-all-out impact of training, but from a competitive busines or industry-structure lens, we’re looking at the three or four big players competing their utmost ultimately, if unintentionally, to turn foundation model access into commodity.
To the capabilities-maximalist minded (typical among engineers - my former life so I’m familiar don’t lack guilt in committing that) folks who will say “Oh the foundation model megacorps will just build out any wrapper whenever one of their third party wrapper plays demonstrates enough adoption, my rejoinder:
Apple did not rebuild an Uber-like app and cut Uber out.
We’ll see how this OpenAI legal services industry wrapper plays out, but I suspect 1) the third party legal wrapper plays will run to other foundation models not doing a legal wrapper, and 2) 3rd party wrappers will do a better job of it since it’s their all-out focus, unlike OpenAI’s whose priorities are necessarily more generalist.
Yes, we all remember the breakout startup failure-arguing quote “Google has entered your space.” That worked for several high profile applications. I believe more of those bets died on the vine than broke-out succeeded however, we only remember the biggest ones that persisted.
If legal services AI turns into one of the Mail or Maps-scale applications of the AI industry, while that would be a fair strategic action counter to the thesis I’ve laid out, the thesis itself would still tolerate it. It’s a question of short-fat tail vs mid-to-long-tail application scope & attractiveness. For example, I think it’s clear that coding is one of these short-fat-tail applications, and the low-no code plays are absolutely having their lunch eaten to acqui-hire ‘death’. I just doubt that the same will persistently transpire facing all professional service wrapper plays.
I'm sure there were good reaasons for this, but man this just sounds bad. Like that's the spec I think NSA must give to their contractors outfitting 611 Folsom Street's Room 641A
There’s no such thing as a Golden Gate Bridge.
Prove it.
See Colin Burke and Pieces of the Action
Yes. At best now the mother of all cautionary tales.
"We defund the corridor and then wonder where the corridor conversations went." this is a claude-ist construction.
"This is an old worry wearing new clothes" this is a very claude-ist construction.
(rather ironically... as @embedding-shaep pointed out earlier): "Outsource the writing and you have not accelerated the thinking; you have skipped it." 'not X but punchy-Y' (not to be confused with 'not X but profound-Y'.
I'm not saying the author shouldn't have used an LLM - once in a while I suppose it gets used to good effect. But I wouldn't kid myself that the writing is certainly all human through-and-through.
[Incidentally, in case anyone's wondering where many of these claude-isms come from, just search within lesswrong.com .]
" A variant of these viruses capable of human-to-human spread would therefore be of very high concern. Moreover, it is possible that such a variant could also have capacity for severe disease outside of the respiratory tract. Unlike other influenza variants, H5 viruses (of which this avian virus is one) often show striking brain involvement in cats, foxes, ferrets, and some human cases. A pandemic variant with such properties would be especially concerning due to its potential to increase disease severity, confuse diagnosis, and hinder treatment.
As in the first case study, this research was clearly dual use in nature. Understanding the genetic basis of these specific viral traits could help in the early identification of naturally-emerging versions of the virus—versions with the potential to cause a human pandemic" (emphasis mine)
This statement flirts with the Ron Fouchier (Netherlands) risky-grant-justification thesis, repeated ad nauseam by Peter Daszak in grant applications, who has been cut off from federal funding.
1. Premise: it would be good to surveil for & monitor viruses in nature that are near-ready to spill over to humans from nature;
2. Protocol: We will serially passage bird flu in ferrets until its virulence and/or transmissibility is high. (ferrets are treated as a model mammal stand-in for humans) Comparing genetic changes (mutations) as sequenced along the passaging pathway will tell us what to surveil for in nature.
As has long been debated in recent years, we have no idea if nature (in any given natural instance, if ever) will choose the pathway that serial passaging (in one given lab instance) produced in order to demonstrate higher virulence and/or transmissibility in humans.
Formally, Anthropic's statement recapitulates the premise only, and we don't know what protocol (the "Understanding the genetic basis of these specific viral traits" part) if any was being queried for. Whether a given regulatory regime's policy allows say for purely in silico investigation of same, for the result to be credible it would need to have been leveraging an empirically-verified (i.e. real-world) training set. Generating that training set would risk creating the pandemic that its supporting grant application tries at justifying to prevent.
But the offending prompter and similar user-LLM exchanges' potential to enable GMDs (Grants of Mass Destruction) should remind us to be very much on our guard against epistemologically bankrupt protocol outlines enabled by LLMs & their prompters' motivated reasoning.
proud disclaimer: I am an advisor to BiosafetyNow.
Here, have a Kevin Esvelt, now-tenured professor at MIT: https://www.nytimes.com/2026/04/29/us/ai-chatbots-biological...
disclosure: I am an advisor for BiosafetyNow.
If I don't trust the credentialed virologists without AI based on perceived precedent, I'm certainly not going to trust them with AI to accelerate their their unabated workstreams.
Note: per my HN profile, I am an advisor for BiosafetyNow.
The 'will not' list in here I Just learned about today, https://www.solzhenitsyncenter.org/live-not-by-lies it easily maps to the employment situation question.
(By the way this is not to say that all nomads are low-skilled or even low-sw-skill, not by a long shot. I’ve met plenty of CS-degreed nomads who I treat as the wizened experts that they are, from whom deferentially elicit their pearls of hard-won software project wisdom. It was one of these even who, non-derisively, recognized the ‘pulling the slot machine lever’ reflex among vibecoders after I posed the apparent addictive tendency. On later describing this to a longtime friend deeply conversant in social science, he immediately responded with a nod and the phrase ‘variable reward response’.)
Also, my coming from being a non-coder, I have a lot of appreciation for the possibilities for project failure one way or another due to a data model or project schema being wrong, even though I still only have a superficial understanding of what either of those concepts even are. . My question is, does your conception of data models in the abstract come from a formal academic course, like an algo’s & data structures course, or from trade-knowledge acquired through the practitioner grapevine?