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rrock

607 karma · joined February 3, 2014

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rrock··on New research on anesthesia and microtubules gives new clues about consciousness
Surprising that anyone still thinks the Penrose model could work. Microtubules do not exhibit harmonic motion like violin strings. The reason is that all motion at the length scale of cells or smaller is heavily overdamped.

The environment within a cell is nonintuitive. To find out more about this, read “Life at low Reynolds number” or “Mechanics of Motor Proteins and the Cytoskeleton” by Joe Howard.

rrock··on Open-source could finally get the world’s microscopes speaking the same language
Lossy compression is a bad idea for scientific images. For instance, we often need to understand the statistics of photon detection events in background regions. That’s one of the first things to get tossed.
rrock··on Slime Molds [video]
It wasn’t entirely clear in the parts that I watched, but my understanding is that slime molds are actually “social” amoeba. They often crawl around as loners, eating whatever they can find. But if they run out of food, they start sending out chemoattractants to all of their buddies in the neighborhood. They all crawl together and create a fruiting body (a spore) that eventually will break off in the wind and land somewhere else. Hopefully, in greener pastures. Those fruiting bodies are what you see in these videos. Amazing creatures, they live on the brink of multicellular eukaryotes.
rrock··on Possible toxicity of chronic CO2 exposure associated with face mask use
3% CO2 from mask wearing? I doubt it. I recently needed to measure 5% CO2, and I had to hold my breath to near-passout levels to reach 5% on the monitor. There’s no way that I could tolerate 3% for any length of time.

More likely these authors cherry-picked studies with typos in them.

rrock··on The Geomagnetic Storm Continues
Bit flips from cosmic rays. Earth’s magnetic field helps to shield us, but is disrupted now. I work with a CCD camera in a sub basement lab. On a normal day we see a stray cosmic ray every couple of minutes (as a hot pixel). On a day like today, might be every couple of seconds.
rrock··on EBUG: The NHL's emergency backup goalie rule
He saved all seven shots against, if I recall. And one of them he stood on his head.
rrock··on SARS-CoV-2 contains part of a patented genetic sequence
Generally, the reverse complement of a translated sequence is uninteresting. The function is not encoded in the reverse complement.
rrock··on Covid-19: Runny nose, headache, and fatigue are commonest symptoms of omicron
Exponential growth easily crushes any attempts to surge capacity.
rrock··on SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination
Note that MDPI is a predatory journal.

@dang, this is not from nih.gov, you might want to fix that.

rrock··on Ask HN: Best Alternative to Homebrew in 2021?
You’re right. Some of us only realized our mistake when it was too late.
rrock··on Ask HN: Best Alternative to Homebrew in 2021?
Certainly. For me it started when they removed the entire scientific stack, which broke my install scripts / brewfile. Then, they removed the ability to customize builds, which broke my emacs build. Also hit the OP issues.

In every case they were removing features that were working just fine, and in the process creating work for me. Got fed up, switched to macports (after checking out nix), and so far things are back to the way I like it.

rrock··on Ask HN: Best Alternative to Homebrew in 2021?
One vote in favor of macports here. I first went from homebrew to nix. Nix was fine, the concept is great but I found the language to be difficult. Ports is closer to homebrew in its simplicity, and has a big catalog (including much of the scientific stack that was removed from homebrew).
rrock··on EU scientists reveal long-term brain damage caused by Covid
The polyA tail is in the 3′ UTR (after the stop codon) and is not translated. It doesn’t appear in the final protein sequence. It’s also a fairly standard feature.
rrock··on EU scientists reveal long-term brain damage caused by Covid
Given the two dozen or so known causes of myocarditis, the vaccine does not stand out here. The risks of complications from the virus do stand out, in stark contrast.
rrock··on EU scientists reveal long-term brain damage caused by Covid
There is no spike protein in the vaccine. There is mRNA. That mRNA needs ribosomes to make the spike protein. So think about where there are ribosomes, and where the protein is made, and you’ll find the correct answer.

I don’t know where you heard the second point, but it is equally incorrect. The mRNA encodes just the spike, with two mutations to lock it into a pre-fusion conformation. Nothing there that qualifies as a “larger stable base”. The sequence is found here: https://web.archive.org/web/20210105162941/https://mednet-co...

rrock··on EU scientists reveal long-term brain damage caused by Covid
The vaccine produces spike protein within your deltoid muscle cells, where it is rapidly degraded and presented to your immune system. It’s not running around in your bloodstream. Unlike the virus. Which means, incidentally, that if this is a concern of yours you should definitely prefer getting the vaccine to getting an infection.
rrock··on My Tungsten Cube (2019)
Tungsten beads are also popular as a weight for fly fishing nymphs due to their density.
rrock··on FDA Approves First Covid-19 Vaccine
In addition, in April we didn’t have the delta variant in the US.
rrock··on FDA Approves First Covid-19 Vaccine
Transcription causes mutations in the spike that causes clotting issues? Do you have any idea how much transcription happens in your cells, every moment of every day? You need to reconsider where you’re getting your information.
rrock··on FDA Approves First Covid-19 Vaccine
As does the virus itself. Many, many ingredients.
rrock··on The Emacs Lock-In Effect or the Emacs Sunk Cost Fallacy
One of the major things that keeps me in Emacs is the keyboard macros. Being able to record a key sequence is something that I use regularly, and I don’t think the major competitors have it yet.
rrock··on Brain imaging before and after Covid-19 in UK Biobank
I guess it’s a good thing that the vaccine makes spike protein within your deltoid muscle cells, so it can’t float over to your brain. And it all gets quickly degraded anyway.
rrock··on What's bad about Julia?
You might have some sort of dangling config issue somewhere? I use the emacs keybindings in the Julia REPL all the time. They work fine out of the box (at least here).
rrock··on Ivermectin as a Covid-19 Therapy
The flag on this article is unwarranted. Derek’s analysis is excellent.
rrock··on Science relies on constructive criticism. How to keep it useful and respectful
Excellent advice. I'd add one more thought for the reviewers side of the equation (peer review specifically). Your objective as a reviewer is to help the authors present their case. Keeping that in mind helps to separate what additional work is essential vs. Nice to have if given unlimited time and resources. Beginning reviewers tend to lean toward the latter.

It takes training and practice to write useful reviews / critiques. Mentors should take the time to do this for their trainees.

rrock··on Hockey goalies are too big now
I’m sure that Vasilevskiy didn’t pop up immediately there because he was exhausted. If his team turns it over, he’s back on his feet in an instant. No way he stays on his knees the whole game
rrock··on Hockey goalies are too big now
I had the same reaction. Has he not noticed goalies playing at the top of the crease (still)? Goalies play from the standing position for as long as the can to leverage their quickness, only dropping to the butterfly when the shot is on its way or a defensive breakdown demands it. I was really surprised to see who wrote it.
rrock··on Hockey goalies are too big now
Yes, and is played on a frozen soccer field, 11 on 11. No boards, the ball can go out of bounds. Scoring is much higher.

(Others may correct me, I’ve been to one bandy game my whole Life)

rrock··on Adequate Vitamin D Levels Cuts Risk of Dying from Covid-19 in Half, Study Finds
Swedes tend to get a good amount of vitamin D from the herring and salmon in their diet.
rrock··on Optical Tweezers
For those interested, here is Arthur Ashkin giving what would have been his 2018 Nobel Lecture in Aspen, Colorado, in early 2019. He was unable to travel to Stockholm at the time. The talk is quite accessible if you want to understand how tweezers work.

https://youtu.be/vb58pd2ycKQ

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