sandwichsphinx

> Adverse childhood experiences (ACEs) are potentially traumatic or stressful events that occur in the first 18 years of life (V. J. Felitti et al., 2019). Exposure to ACEs typically consists of childhood exposure to abuse (sexual, physical, emotional), neglect (physical or emotional), or household dysfunction (parental mental health or substance use challenge, divorce, witnessing domestic violence, parental incarceration, etc.).

I skimmed through the interesting parts of the paper, and studies like this are important for encouraging more efforts toward prevention. But what can we do for the people who have already experienced this? How can we undo the damage, especially when the effects seem significant and permanent?

I'm not aware of anything that specifically tells you submissions per day, tho I'm sure something can be built using the official API (github link is in the footer) since you get access to users and their submissions data

My ‘unrealistic’ motivation is this dream of designing my own chip based on the POWER ISA to use as a dedicated workstation. The idea is so exciting because of how much technical expertise is required—it’s not like anyone has a semiconductor fabrication facility in their garage… oh, wait.

https://www.wired.com/story/22-year-old-builds-chips-parents...

> I’m realizing I’m wholly unmotivated

"He who has a why to live for can bear almost any how." What I learned that keeps me motivated is figuring out how to dangle a carrot in front of myself, some goal that depends on me figuring out something so that I can reach that goal. It helped me asking myself, "if I could have anything in the world, no matter what, what would it be and why?" and then going about bridging the gap between A (where you are now) and B, that future where you have that state you really want, even if it isn't very realistic. Might not work if this end state doesn't relate to tech but in my case it has and is proving to be sustainable thus far.

Start with reading "Thinking and Reasoning: A Very Short Introduction" by Jonathan St B. T. Evans (Oxford University Press, 2017). Very short read and bonus points if you find it at your local public library. At the end of the book, there's a list of suggested further reading if you want more depth.

National Geographic Mission to the Sun

Cisco Webex

I trust sites that aren't heavy with javascript (less ad tech and so better privacy). In my experience, banks sites are often optimized to run on low end user devices and so make good use of old fashion HTTP requests for managing interactivity.

The only tool I truly find magically despite how boring it sounds is chatGPT, I can tell it everything as a living dev log, I tell it time date when I do things and why and so on just documentating my progress, listing todos and reminders as I go but now I can "talk" back forth on the administrative things like reminding me where I was, recap here, it's just great for managing boring things like I never been able to do before

>Who is Windows For?

I like using Windows as a personal air gap system because of how nice it is to write custom win32 applications. I usually gut the system with Rufus, winget to remove as many apps, powershell to maximize a few other things, and the registry for whatever else needs to be changed but the system left I think is really nice.

books in general, no, but in my experience the oxford very short introduction series is because it covers the same type of writing of the blogs I would read, the typically short form niche expertly things on substack/medium/blogspot/etc etc. not a lot of people seem to be familiar with the series, I wasn't until I randomly saw a dedicated corner at my library https://global.oup.com/academic/content/series/v/very-short-... they have almost a tiny book for any specific niche subject and until I run out of books in this list to read, I don't really have a need for reading blogs anymore

no, I mainly switched to reading physical books from the local public library. the oxford a very short introduction series has been a nice drop in replacement

title character limit

Why not create the discord and share an invite to see if any people join? Less friction than having to send an email

I don't think about quiting social media because it gets lonely but I do think about changing platforms occassionally

alternative link if you don't have access to the ACM library

https://ics.uci.edu/~cs237/reading/files/howtoread.pdf

(you can find the above if you search for the paper in google scholar)

> to bypass the difficulties of working with membrane proteins in the laboratory, the team used AlphaFold to predict interactions between proteins

> AlphaFold predicted that three sperm proteins work together to form a complex. Two of these proteins were previously known to be important for fertility.

https://www.nature.com/articles/nature18448

Here’s the paper linked in the article.

Does anyone have experience using AlphaFold? I don’t have a Nature subscription to see how they specifically accomplished this, but I glanced at the AlphaFold GitHub, and I can’t quite wrap my head around getting it to predict something like this. I’m sure it’s not as simple as prompting ChatGPT with a verbal question.

great project, any plans to implement voice chat features?

> Dr. Tong says, "The genome of this novel strain of Eremiobacterota enables it to metabolize ammonium ions found in cleaning products. The strain also has genes for alcohol and aldehyde dehydrogenases to break down residual alcohol found in common disinfectants.

really interesting article, here's the paper linked in the article if you want to jump straight into that

> Diverse and specialized metabolic capabilities of microbes in oligotrophic built environments

https://microbiomejournal.biomedcentral.com/articles/10.1186...

Given a long but finite time horizon, I believe humanity could (and I believe will as well) create an AI capable of lasting a billion years. If we look at the lifespan of life on Earth, around 4 billion years give take, it’s clear that long-term systems can persist under the right conditions. If we have approximately 7 billion years left before the sun becomes a problem, creating an AI using self-replicating systems, possibly through wetware or bio-engineered components, could allow it to endure for such an extended period. The key would be ensuring that it can maintain itself, adapt, and evolve over time.

Technologically feasible? Probably and likely

I use ChatGPT Plus and Claude Pro via their web interfaces only

The article doesn't mention their role but if someone is fired over $25, can we really justify that they were ever worth a $400k salary?

When is the AI bubble expected to burst? Any forecasts or timeframes—whether short-term or long-term—being proposed with high or low confidence?

> ASML expects net sales for 2025 to come in between 30 billion euros and 35 billion euros ($32.7 billion and $38.1 billion). This is at the lower half of the range ASML had guided previously.

> China-based customers had stockpiled DUV machines to get ahead of the U.S. exports — now, demand in the country is expected to dry up significantly

I wonder where this demand will be going to instead, SMIC?

For local large language models, my current setup is Ollama running on my M1 Mac Mini with 8GB of RAM, using whatever SOTA 8B model comes out. I used to have a more powerful workstation I built in 2016 with three GTX 1070s, but the capacitors were falling off, and I could not justify replacing it when Claude and ChatGPT subscriptions are more than enough for me. I plan on building a new dedicated workstation as soon as the first-mover disadvantage comes down. Today's hardware is still too early and too expensive to warrant any significant personal investment, in my opinion.

When I have trouble diagnosing something, I reach into literature for clues. Your post reminded me about this paper from 2016, reading it might prove to be helpful for you.

>Are You Your Friends’ Friend? Poor Perception of Friendship Ties Limits the Ability to Promote Behavioral Change

https://journals.plos.org/plosone/article?id=10.1371/journal...

the project euler forum is nice

> I browse /new exclusively

I do the same because I'm usually looking for things others would miss. Reading something unpopular typically has a higher value because of information asymmetry.

Thinking and Reasoning: A Very Short Introduction by Jonathan St B. T. Evans, 2017 Oxford University Press