I've used psilocybin twice and both times it busted me out of a long-lasting and difficult bout of depression. I should use psilocybin more often to maintain a healthy and happy outlook on life (or maybe just quit the startup world and do something more sane).
You might not know which people you know use drugs. Unfortunately, due to the illegality of many useful and helpful drugs, more harmful ones have become popular. Not all drugs are created equal.