395 karma · joined November 10, 2020
i make more money trading options and have way more fun! in a way - it is "real" science in a way whereas the modern Life Science Industrial Complex is anything but that.
But what I garner is that AI/robotics led wet lab work is in progress. And hacking the AI running the wet lab to make a virus is definitely plausible as that seems to be one of the directions we’re going in the AI+biopharma space
every few weeks though i test claude and chatgpt on their scientific reasoning and it has definitely improved over time. in my experience without specific instruction on what is known/unknown they typically are lagging behind the leading edge of the field (dev bio/pluripotency in my case). probably because scientific research articles are not open-source so they can't crawl them.
claude has definitely outperformed chatgpt in this regard however, it's scientific reasoning is impressive.
science as an apparatus often works on timescales that are decades, not 4 year political cycles. so rapid pendulum swings are particularly dangerous to the pursuit of science as a whole. you could just as easily describe a scenario where the pendulum has swung left instead of right and a bunch of right-leaning research gets cut and people lose their jobs, we lose progress etc.
these days i'm pretty in favor of a system where funding is guaranteed and investigators are allowed absolute academic freedom. think something along the lines of each principle investigator gets $Xmillion to study their research topic in perpetuity without fear of reprisals or sudden funding cuts.
i naively think this would solve a LOT of the issues in academia currently, which already in the absence of the recent Trump shake-ups has devolved into a metric chasing, paper-mill, grant funding behemoth whose sole purpose is to churn out papers of dubious quality, game metrics, and bring in research funding to the university. the modern professor's job is not to advance our understanding of the natural world, but to generate positive KPIs and bring in as much revenue as possible to the university in the form of overhead costs (66% of all the federal funding we bring in at my institution goes directly to the school). it's a business, and that's not what basic science research is supposed to be in my opinion.
Meanwhile the Alz and Neuro field as a whole are well established, and the amyloid hypothesis was a foundational theory taken as a fact. Any initial questioning of this and they would brand you as a lunatic.
naive question: why has no one made an app with the reverse incentive structure? i understand that the current business model is much more lucrative...but i feel like with how fed up people are with the inability of modern online dating to provide quality, long-lasting relationships a new platform that optimizes for match quality and longevity would eat all of Match Groups offerings lunches. i guess there just isn't enough money to be made so it's not even worth it?
top on my list of things to do if i were a billionaire: launch an institute for the sole purpose of reproducing other's findings.
firstly, there are basically no legal repercussions for scientific misconduct (e.g. falsifying data, fake images, etc.). most individuals who are caught doing this get either 1) a slap on the wrist if they are too big to fail or in the employ of those who are too big to fail or 2) disbarred, banned, and lose their jobs. i don't see why you can go to jail for lying to investors about the number of users in your app but don't go to jail for lying to the public, government, and members of the scientific community about your results.
secondly, due to the over production of PhD's and limited number of professorship slots competition has become so incredibly intense that in order to even be considered for these jobs you must have Nature, Cell, and Science papers (or the field equivalent). for those desperate for the job their academic career is over either way if they caught falsifying data or if they don't get the professorship. so if your project is not going the way you want it to then...
sad state of things all around. i've personally witnessed enough misconduct that i have made the decision to leave the field entirely and go do something else.
at the beginning 2022 it was useless because the output was garbage (hallucinations and fake data).
nowadays its still useless, but for different reasons. it just regurgitates things already known and published and is unable to come up with novel hypotheses and mechanisms and how to test them. which makes sense, for how i understand LLMs operate.
while the author is correct that the for-profit publishing is definitely a negative externality, i can't help but feel they are missing the forest for the trees when it comes to all the other worse issues in academia.
a full explanation of which would be much too onerous for a hn comment, but in no particular order: rampant scientific fraud, waste of tax payer dollars, wage suppression via "students" and visa-dependent laborers (J1 visa abuse), publish or perish evaluation criteria, lack of management training, blatant and rampant racism, etc. etc. etc.
the whole system needs to burn down and be rebuilt from the ground up.
your location is assigned based on a competitive bidding system where you select from a list of cities to do your next tour. some countries/cities are obviously dangerous for a variety of reasons and they are called "hardship tours" (think iraq or afghanistan). you get bonus money for these and sometimes are forbidden from bringing family.
posts in places like Europe or East Asia are very desirable and highly competitive. but often it's a matter of fit. my dad was a hedge fund manager before the Foreign Service so his first posting was actually in Frankfurt. you can also do a tour in the continental US, such as in DC or NY. because of his economics background he has done a few of those.
most of the time the head ambassador is a political appointee, but the grunts are regular people who have made this their career.
i would say that we firmly live in the American Empire with techno-feudalistic tendencies, but a historical event of such magnitude as the complete dissolution of the American state will probably see a reversal to a more traditional feudal system. Think Jeff Bezos and Bill Gates buying up and becoming the Dukes of the PNW.
personally though i don't think we are at this stage yet or even close to it. until the federal government becomes COMPLETELY inept and the average citizen cannot buy food, this won't happen. yes market conditions are currently not the best but we are nowhere near starvation.
the witness and reportee who i am friends with was directly instructed by this professor to falsify data in a more positive light in order to impress grant funders. multiple people were in attendance in this meeting but even that was not enough to see any disciplinary action.
duke also has a notorious reputation for being a fraud mill.
in every other industry that i can imagine, purposely committing fraud has been made illegal. this is not the case in modern science, and in my opinion the primary driver of things like the replication crisis and the root of all the other problems plaguing academia at the moment.
In 2025 it seems integrity is meaningless, “winning” is all that matters. Particularly, you are not punished for acting without integrity but definitely “punished” for having it.
How do I declare for the inaugural Hedge Fund Draft?
Prostaglandins are an inflammatory hormone that do a variety of things, but specifically PGE2 plays a role in muscle stem cell activation to divide and produce more muscle fibers. The effect is probably realistically small, but you will leave gains on the table by taking ibuprofen after hard workouts.
Except for the founders/early employees who get a modest (sometimes excessive) paycheck.
Bad modern parents just give their kids an iPad.
Give me a break, it's a hammer. This is a perfectly normal "use" of ChatGPT and a good example of how a literature student may opt to try and use AI to make their work easier in some way. It also conveniently demonstrates some of the shortcomings of using a LLM for this sort of task. No need to call them a dumbass.
Mostly which are that our system only rewards one thing in education: the grade. Not understanding, knowledge, intelligence, but instead a single number that is more easily gamified than anything. And this single number (your GPA) is the single most important thing for every level from middle school to college where it will unironically determine your entire (academic/academic-adjacent) future.