thereticent

Just keeping you on your toes?

I had the same thought, but occupation on the birth certificate is the "usual" occupation the person held.

Again, you of undue certainty: the government attempted this potentially legal avenue, and it was adjudicated as impermissible. Meaning what they tried didn't work. Why are you acting like no one else here understands what has happened? Probability dictates that you are almost certainly not the smartest person in the room.

You can say this person is an idiot all you want, but the fact of the matter is that if DoD does not want to deal with Anthropic through Palantir, their only legal recourse at this point is to drop Palantir. They shot their shot with this legal gamble to remove Anthropic from the supply chain, and they failed. That's it. Curtains or deal with it.

I've own both, and this one had a nice sticky/tacky sound without a tacky feel. The Model M felt and sounded like loading a releasing a spring!

I saw that another commenter suggested this one may have been a repackaged Model M. If it was, it must have had different switches that I preferred.

Love that.

As an aside, that keyboard in particular had the best click I've ever experienced.

Genuinely curious, not being combative...what very interesting things have happened in the crypto space lately?

That makes total sense to me. I've avoided onions most of my life. More saliently, I agree that it's off-putting to hide the inclusion of artificial sweeteners. Thanks for your response--I appreciate it.

Redundant! Every UPC barcode has a 6 on the beginning, middle, and end. If you've got the mark of the Beast you may as well get Beast Bux.

I've never seen reliable data suggesting that sucralose is harmful. Could be wrong. If you wouldn't mind giving sources, that would be helpful. Or is it just a personal sensitivity? Don't mean to pry. I'm just curious about the issue.

One of the Gnossiennes was in Spider Forest as well -- great Korean psychological horror.

I think the other commenter is right...you're thinking of DVD-R vs DVD+R, possibly even DVD-RW and DVD+RW.

Based on the specs listed, OP was in college just before me or may have overlapped. The big gold CD-R stacks (you could bur in jewel cases, on spindles, or just gross stacks which were nice and cheap) were a huge thing with my group (who encoded to FLAC & MP3 -V0 and burned audio CDs relentlessly. We felt we were archiving our liberal arts college music library and radio library for the future! Who knows. Some of that "future" is still backed up and on hard disks, and I should migrate them to SSD or tape just on principle.

At that point CD-R were cheaper than CD-RWs, and because most archiving/distributing didn't require rewriting (not return-on-investment wise anyway), we just shared programs on CD-R as well. In some ways it was a beautiful technology! Particularly fidelity to a spec everyone tried to bend and break for a profit angle, when honestly, there was no point for many of us using CD-R

Is that really what "wow" means here? I took it more as "wow, I've been around forever / I must be old now" or something similarly tame.

Sorry, yes. I was thinking net worth > 0.

Are you in the black as a household overall?

We aren't yet. Our projection is that we will be in 5-7 years. I'm turning forty soon.

Just to give you an anchor point.

Same here, but we are in a very similar boat in our voyage through socioeconomic statuses (though I'm in Ohio River Valley US). I may be fooled by the discourse that [Xennials/Oregon Trail gen/Gen Y/Elder Millennials], but we supposedly saved more, delayed gratification, planned more, and worked more than even Gen Z (who, don't get me wrong, have it worse because of undercompensation vs purchasing power and sheer hopelessness).

I doubt we're typical, is my point.

I feel you. What's worse: amyloid aggregates aren't fraud either, but certain ones are more conducive to fraud, and the fraudsters have been loudly denounced.

There is absolutely no question--none at all--that amyloid plaques are a key feature of Alzheimer disease, that they are neurotoxic, and that they fit within a number of mechanistic pathways contributing to dementia (which is the broad clinical phenotype).

Interestingly enough, the actual results of the lecanemab (Leqembi) trial is that those on drug had overall 17 months longer in the mild cognitive impairment / mild dementia range before declining to the moderate dementia range. It doesn't stop the disease, but it does measurably slow its course, and that makes a huge difference to families. Whether the linked author can accept that progress is mostly incremental and not wholly satisfying is, I don't know...his problem, but it is rapidly becoming our problem as dementia scientists.

But people love a conspiracy.

Got to pay someone to do the catching. We all do these reviews for nothing! Manuscript peer-reviews, and yes, even the major NIH study sections that review numerous grants every submission cycle.

I agree that the toothpaste is out of the tube here. But do the mods have to fix the reddit community? If HN gets out of hand, is that dang's fault?

For most of us it's a thankless job full of many uncompensated and thankless tasks, but we do it for any number of reasons. Most academic scientists I meet are capable and (mostly) driven by a desire to uncover knowledge.

I appreciate the moral support from someone on the private research side. Politics aside, we all tend to value the common goal of improving population health, even if egos are tempted by perverse incentives.

It's also my field. One clarification I would make is, I think, foundational. The amyloid research that was famously falsified was not the mainstream "amyloid hypothesis" research. It was a very niche subset, as GP described.

As for people feeling shut out of funding: people feel a lot of things all the time, but I've never seen a good idea be repeatedly denied funding because it wasn't amyloid-primary. Unfortunately, it's usually a lack of rigor, lack of pertinence, lack of preliminary data demonstrating plausibility and feasibility, or some combination. Not always--there are big money and prestige politics going on all the time, but that has nothing to do with amyloid.

To add another nearly useless data point, my lab and those I collaborate with focus on amyloid as well as tau, alpha-synuclein, TDP-43, microvascular changes, and inflammatory contributions. Metabolomics, proteomics, and transcriptomics are other big systems biological approaches. Not to mention social determinants of health, which are also massive.

All that said, I'll read the book, but the "daring journalist finds a crew of whistleblowers" framing strokes me as either ignorant or disingenuous. Off-putting either way, as we face major cuts to public funding of health science, which has overall been an extremely generative and sustainable model for improving national and world health.

I'm impressed with your dedication and also amazed that I ran into this on HN. My 9-year-old just showed me your Geometry Dash remake in Scratch. You're like a legend to him and his friends!

This is my field, and I can't tell, nor do I want to look up yet more papers to figure it out when they don't say it plain. But with methods sections relegated to footnote status, what do we expect? Of course they don't know how to write a paper, and/or of course the reviewers and editors can't tell that it's too vague.

Medical publishing is still a cartel, and academic medicine is always attached to big business enterprises. They want to see the number go up. Meanwhile, manuscript submission fees are in the thousands, and journals are insisting on shorter and shorter deadlines for the unpaid peer reviewers. It's a shit show.

You just described the exact end goal of my overall research program, if we can keep the stroke, AD, and Down syndrome + AD cohorts running. Associating blood biomarkers differentially with individual disease processes and comorbid health factors is the holy grail.

Perverse professional norms and plenty of miscreants have made it a much harder road for other dementia researchers, but it's worth keeping on, and there are so many avenues that haven't been pursued.

From a long-time HN user: please provide a high quality source when making claims connected to a people group. This place works better when we avoid culture wars and demographic-based blame.

BlueStacks seems to work great for games. Compared to Nox anyway, and even that was so cool when I first found it. I've heard of LD Player as well but haven't used it.

Is it more difficult to get non-gaming apps working?

Ah, good point. I was picturing this setup as hardwired.

My understanding is that insurance will not cover issues caused by DIY work if you did not have it permitted and inspected properly afterward. I sincerely doubt that an insurance company would be required to cover losses due to DIY electronics using parts that have not been properly safety rated. I'm surprised you think the opposite is obvious. Could just be my US perspective.

I chose the Boox over ReMarkable 2 for that reason and the color display. In split-screen, I pretty quickly got used to zooming in on a column or full body width and dragging the PDF around to read it. I guess it's not perfect, but still better than paper or traditional screen for me

My memory from the US Midwest is that Williamsburg already had a reputation as a hipster-level gentrifying area--to the point that the PBR-sipping indie set was already eschewing it for Bushwick. Then again, whomever I spoke to could have been parroting an odd blogosphere take by then.

And yet somehow our new policy at a huge R1 university now forbids Firefox but installs Chrome by default.