Hacker News Reader

tima101on A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide

> Of the 2909 participants in the intention-to-treat population, 1935 received enlicitide and 969 received placebo (5 did not receive enlicitide or placebo). The mean age of the participants was 63 years, and 39.3% were women. The mean (±SD) LDL cholesterol level at baseline was 96.1±38.9 mg per deciliter. The mean percent change in LDL cholesterol levels at week 24 was −57.1% (95% confidence interval [CI], −61.8 to −52.5) with enlicitide and 3.0% (95% CI, 0.9 to 5.1) with placebo, representing an adjusted between-group difference of −55.8 percentage points (95% CI, −60.9 to −50.7; P<0.001). The mean percent change in LDL cholesterol level at week 52, the mean percent changes in non-HDL cholesterol and apolipoprotein B levels at week 24, and the percent change in lipoprotein(a) levels at week 24 were significantly greater with enlicitide than with placebo (P<0.001 for all comparisons). The incidence of adverse events did not appear to differ between the groups.

tima101on Scientists find a way to regrow cartilage in mice and human tissue samples

https://www.science.org/doi/10.1126/science.adx6649

A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.

tima101on Ask HN: Books Like Building Git?

~1500 people disagree with you and some of them bought both books ($99 and $250).

Yes, a lot of online tutorial and snippets. No argument here. Not a lot of material to build a complete project. The value is in "Fractured" vs "Whole" knowledge tree.

tima101on Life is not short

Yes, we are North-East, not far from Canadian border. A lot of snow, cold winters. We haven't lived in SE WA but visited the area you mentioned 3-4 times. The area between Pullman and, say, Kennewick. Way fewer trees, lower altitude but winters are less cold and less snowy. I would say there is no perfect place. Once you checked your main checkboxes, paradise is a state of mind, not place itself. You will have hot summers. We are at higher altitude, I have tractor primarily for snow but summers are much cooler. And we like cooler summers. This June was mostly at 68-75F, our german shepherd and I love it. I talked to a person from Texas and he mentioned 90-95F in May and 95-100F in June - no, thank you very much. We even bought land in HI at 3000 ft elevation to have 75F in summer and 72F in winter for the same reason.

South-East WA will have hotter summers, no shade from trees and every time we visited it was windy. having said that rolling hills are beautiful, farmers are nice, some healthy rivers for fishing. Pullman and Moscow have shopping and amenities.

tima101on Life is not short

No kids for now but we are making plans. My wife is younger than me and we are planning to have kids in the next 1-2 years. Before we have kids we will decide and settle in one place. We will probably keep our second homestead since we are emotionally attached to it.

tima101on Life is not short

Similar story here. We traveled with my wife for 3.5 years. Then we built homestead on 30 acres of forest land in rural WA. Now I am 36 and we bought land in HI to build our second homestead. And it is from scratch again! Most of our income comes from freelance gigs. The last time I visited big city was over 10 years ago. No regrets here.

I think the best framework is to not compare yourself to others. And fear of change is a normal, ordinary feeling. Comparing to others makes no sense, just try to do things that YOU will not regret and things that make you happy in long term.

tima101on We were a few days away from being settled for life

No evidence for this particular case but can investors or competitors just gain private information about a company by pretending to buy it? It's free and the info is very detailed.

tima101on Relying on sanctions to stop Russia could go ‘terribly wrong’

And nuclear war argument is fear mongering by corporate media. Breaking Putin's army in Ukraine prevents further escalation. Because Putin has no army to invade other countries and makes it easier for Russian people to replace him with someone more sane.

tima101on Relying on sanctions to stop Russia could go ‘terribly wrong’

Here is one example of short-term thinking.

In 2014 Putin annexed Crimea, there was no reaction from the West. Nil, not even one serious sanction. Corporate interest decided to kick the can down the road.

The year is 2022, the West decides to kick the can down the road again. Corporations blame inflation on Putin meanwhile extracting record-high profits. Win-win, in the short term. There is no cure for human nature, in this case - greed.

tima101on Relying on sanctions to stop Russia could go ‘terribly wrong’

Only thing that will change Putin's mind is his defeat on the battlefield, period. Definitely, not sanctions. He will only stop if stopped by force. Sanctions only affect a very small fraction of Russia's population, so called quasi-middle class. Putin and rich oligarchs have more than enough, the poor majority is not affected.

Why not help Ukraine with jets and anti-air and solve Putin's problem now? It's obvious that corporate US thinks it is less profitable for them to escalate. It's more profitable to let Putin destroy an entire democratic nation. The short-term thinking and greed will backfire eventually. What does the West think Putin, disconnected from reality, power-drunk primate with a grenade in his hand, will do after Ukraine? Stay peaceful?

tima101on Ask HN: To HN people searching for biotech jobs

Thanks for this info!

tima101on Side effects surface in 40% of patients on Biogen's Alzheimer's drug Aduhelm

> The safety data break down like this: 425 out of 1029 patients, or 41.3%, on the 10mg/kg Aduhelm dose experienced ARIA. Serious cases cropped up in 14 of those patients, the JAMA analysis shows. ARIA-edema (ARIA-E), or swelling, was the most common side effect seen in the pooled data, affecting 362 patients, or some 35%. ARIA-microhemorrhage, also known as microbleed, and ARIA-superficial siderosis, which is a type of slow brain bleeding, was observed in 19.1% and 14.7% of patients, respectively.

> Ninety-four (26%) of the 362 patients with ARIA-E experienced symptoms, most commonly headache, confusion, dizziness and nausea, the analysis shows.

> Swelling or bleeding were mild to moderate in those patients, but scans did show severe side effects in 12.2% of patients with swelling, 11.7% in patients with microbleeds and 21.9% in patients with slow brain bleeding.

tima101on What's the best SaaS starter kit?

https://github.com/async-labs/saas is open source (I maintain it)

tima101on Biogen used an FDA back channel to win approval of its Alzheimer’s drug

So two large clinical studies concluded that this antibody drug does not work. Nevertheless, FDA approved drug and Biogen stock went up.

Aren't we just a bunch of greedy monkeys?

PS: Therapy costs $56,000/year. My question stands.

PPS: Seems like Medicare will pay for it, so burden is on taxpayers.

tima101on Software is eating the car

"Has the whole world gone CRAZY?"

tima101on Software is eating the car

I've been shopping for new tractor and found out that some newer tractors have software-controlled regeneration process. Then I watched on Youtube how buggy software in those tractors randomly kicks in regen process and does not allow owner to use tractor. I ended up buying lower HP tractor that has no chip and no regen process.

tima101on Writing books is not really a good idea

Web development, building complete projects JavaScript and TypeScript.

tima101on Writing books is not really a good idea

I encourage all authors to self publish. I self published two books, prices are $99 and $199. I only sold 2500 copies in 3 years but it's a nice supplement to main income since there is no publisher and only fee is Stripe's. I often read online about authors who sold 50,000 or 100,000 copies with big-name publisher but made less money than me. Which is ridiculous.

I recommend having some knowledge for free, for example, open source project. Charge more per copy and expect lower number of sales. Continuously improve project and book. Collect reviews in respectful way.

I am happy to answer any questions.

tima101on Cryptocurrency Is an Abject Disaster

> Cryptocurrency is one of the worst inventions of the 21st century. I am ashamed to share an industry with this exploitative grift. It has failed to be a useful currency, invented a new class of internet abuse, further enriched the rich, wasted staggering amounts of electricity, hastened climate change, ruined hundreds of otherwise promising projects, provided a climate for hundreds of scams to flourish, created shortages and price hikes for consumer hardware, and injected perverse incentives into technology everywhere. Fuck cryptocurrency.

tima101on Show HN: Make continuous reforestation part of your daily workflow

You can also plant trees by yourself. Last year I planted 10 Siberian and Korean pines in one day. 7 trees survived, 3 trees died because I over watered them. So those 7 trees don't actually need any extra care from me.

tima101on I self-learned to code at 30

I agree. I learned to code in my 20s but I felt real confidence only after building multiple products that have real paying customers or products that other web developers use to build their products with paying customers. After building a dozen products, I believe that I can learn and build any feature within technically possible. This was not the case after coding parts of application or going through tutorials, but became the case after building entire applications from scratch for real customers.

EDIT: typos

tima101on GitHub's Web Component Collection

Wow, I like it. I wish I saw this library sooner. I may replace Material-UI library in my current project.

To maintainers, this example link https://github.github.io/time-elements/examples/ is missing from https://github.com/github/time-elements page

tima101on Robinhood now has a 1-Star rating on the Google Play Store

I hope that these events make more people put their savings and time into their own projects instead of bitcoin and stocks.

tima101on Robinhood is limiting purchases of stocks: AMC, Blackberry, Nokia, and GameStop

People who engineered this fake outrage made a lot of money by buying early and selling early, everyone who believed this scam lost money.

Let's punish hedge funds - fake outrage

Stocks are climbing up - fear of missing out

Restrictions on platforms to prevent people from falling into this scam - fake outrage

Scammers' freedom of speech is in danger - fake outrage

Looks like we entered new era where fake outrage on social media (Reddit, HN and Twitter) can make scammers a lot of money.

I am surprised that HN community is falling for this scam.

tima101on Thanks HN: You helped save a company that now helps thousands make a living

Sincere congrats!

I hope, though, people learn that your experience is one of many ways. And "zero to one" and "all or nothing" are not the only ways.

tima101on Permanent suspension of @realDonaldTrump

Would you change your opinion if your life or life of your family member depends on what president says on Twitter?

Can you put yourself into shoes of SOS of Georgia, policeman in DC, senator Lindsey Graham? The mob will tear them apart if they had a chance and mob is advised to do so by Trump. I live in Trump country. A lot of Trump supporters take his calls to action literally.

Should someone's freedom be curbed if it causes harm and death to someone else?

Practically though he will still have ways to reach his base. It'd be okay if they cook in their own soup but problem is that their madness spills over and innocent people get harassed, hurt and now killed. Imagine being on the plane with dozen of Trump supporters and no bodyguard that want to punish you? That's how Mitt Romney felt few days ago. Whose freedom of speech created this situation?

tima101on BadEconomics: Putting $400M of Bitcoin on your company balance sheet

Let's see what happens when there are less people who want to buy bitcoin than people who want to sell bitcoin. Sellers without buyers will end up holding a bag of excrement. Almost no one buys it to use as a currency (except criminals) but because of fear of missing out and desire to make a quick buck.

tima101on Salmon spawning in the upper Columbia River, first in 80 years

No active reactor but 53 million US gallons (200,000 m3) of high-level radioactive waste stored within 177 storage tanks, an additional 25 million cubic feet (710,000 m3) of solid radioactive waste, and areas of heavy Technetium-99 and uranium contaminated groundwater beneath three tank farms.

https://en.m.wikipedia.org/wiki/Hanford_Site

Federal government promised to clean up but failed.

tima101on Salmon spawning in the upper Columbia River, first in 80 years

I live not far from where Columbia river comes out to US from Canada, in US portion of Selkirk Mountains. This is north of Coulee Dam.

It's good that salmon can come into this area but smelter from Trail, BC has been polluting upper Columbia river for about hundred years. With chemicals and smelter sludge. Fish is not edible, sand is black from sludge.

Salmon may have reached upper Columbia river, but water in that part of the river is heavily polluted.

And south of Coulee Dam, there is storage of nuclear waste, just north of Richmond, WA - Hanford site. Nuclear waste already leaks into Columbia river, north of Tri-Cities area.

So in my opinion, human created disasters in the Columbia river, rank in this order: nuclear waste at Hanford site > smelter at Trail, BC > Dams without passage for fish.

Sorry for typos, typing from phone.

tima101on Startups that have hit more than $1K MRR in about 12-24 months

The Church Co - $199/month for ultimate package. You can probably charge churches more since there is lack of technical knowledge. Are founders and employees of Church Co religious or not? Is there any moral barrier in helping churches to collect donations?