If weather is not a factor Albany/Troy/Schenectady NY. The area is home to a good sized and growing tech industry with an AMD chip manufacture, industry leading nano technology research, universities like Rensselaer Polytechnic Institute who have incubator programs
http://www.rpi.edu/about/eve/, and Schenectady whose economy depended so heavily on GE manufacturing is not giving large tax incentives to small businesses to move there. The social life is mid sized city to very rural depending where you want to actually live. I believe it is a hour an a half train ride to NYC, 3 hour drive to Boston, and 2 -3 hour drive will bury you in the middle of the Adirondack state park with no cell service.