If you admit that you have a slight bent towards entrepreneurship or similar you are out of the door instantly. If it’s somewhere like a YC startup and they realize you’re not young and willing to sacrifice your life, same thing.
Edit: to make that less bitter sounding.
To be more helpful: A resume gap that you’ll casually admit to or honesty in monetary requirements also are instant disqualified status these days. No more low interest rate free for all.