266 karma · joined April 17, 2015
In general, titers of the virus in NP swabs should be high enough to withstand 10, maybe 20-plex pooling. However, as you allude to, there are plenty of other effects that can influence PCR. If there is one sample, for example, that contains a PCR inhibitor, like heme, it may then inhibit all the samples it is pooled with.
Additionally, swabs are not just swabs of virus, they also pull of highly variant amounts of bacteria and human material. These things may also affect the efficiency of PCR.
There are tons of mouse labs, however some have specialized mice or mouse systems. There are also other labs that specialize in other animal systems. These systems are nontrivial to switch between for many reasons, which I think you acknowledge. It is useful for the field in general to have access to the results of a variety of research tools that every individual wouldn't necessarily have access to.
Neither does OP.