Orkut. Which was a social media site with 300 million users. Same number as twitter.
Too soon to make a verdict on Nest, but YT and DC seem to be the kind of acquisitions that Google paid a lot for, and from which Google advanced its bottom line and reach. FeedBurner ($100M), on the other hand...$100M is not nothing, but not as major as a Twitter acquisition would presumably be.
(AFAIK, Feedburner is still alive, but the APis have been deprecated a few years ago)