Popper led us astray into a reductive outlook on science that led us directly to the replication crisis in the social sciences, Amy Cuddy and power poses and much more. People act like this is a mathematical problem and it can be fixed moving beyond p-values but it isn't.

Quine had the better thesis, if only for the word "confirmational holism". Science must be holistic -- it must be one across all fields or at least hope to -- or it's a credentials game. As it stands now you can get credit for social science that contradicts physical anthropology directly and doesn't apologize for it.

None of the truly great achievements of science were done through atomized conjectures and refutations. Newton, Lavoisier, Mendeleyev, Darwin -- they all posited entire worldviews that were supported by a patchwork accumulation of evidence. The challenges to Newtonian or Darwinian theory couldn't be merely empirical, they had to embody a whole philosophical attack on this worldview (preferably with evidence of its own -- but challenges to the evidence would never be enough to bring down Darwin in his time).

Quine's confirmational holism might have highlighted the dissonance between GR and QM, but it might also have highlighted the differences between mid-19th century geology (which was beginning to discover deep time) and taxonomic biology. OTOH literally no experiment could be set up to evidence the importance of deep time in biology. Not without the fundamental insights of Darwin (and likeminded, less-accomplished contemporaries).

We need to bury Popper.