Non-labor initial outlay for some hackers to build a software system is well under 100K.
To put together a chemistry lab takes well over 100K (or so I have been informed). Imagine having to spend 100K just to have a spot where people can work.
Those costs of course start to spiral heavily upwards as you get more and more high-tech in your hardware. Then, if you're setting up startups for the hardware world, what's the ExpectedValue of your ROI. Batting average ain't going to be great. So the incentives are skew compared to the software world.
That said, I'd love to be involved in the software side of nuclear energy. Among other things, you can't rely on your memory as a given, since it is more prone to corruption.