Do you think Pixelmator is a good replacement for Fireworks? Fireworks has been really great at allowing me to quickly mock-up different web layout concepts without having to write any HTML code. I know some are in the "concept with HTML camp", but I've found Fireworks to be so much faster. I've never bothered too much with Photoshop since Fireworks did 90% of what I wanted.
I'm like many, however, in grumbling about how crappy Fireworks has gotten (at least on OSX, not sure about Windows) and am to the point that I'm ready to move on.