> Here, we summarize the scientific evidence that informs this debate to provide our fellow scientists and the public with the tools to join the discussion in a constructive and informed manner. Our goal is to dissect the evidence to make it more accessible to those interested in this important problem. ...
> Based on the scientific data collected in the last 3 years by virologists worldwide, hypotheses 1 and 2 are unlikely. Hypotheses 3 and 4 cannot be ruled out by existing evidence. Since hypotheses 1 and 2 support the lab leak theory and hypotheses 3 and 4 are consistent with a zoonotic origin, the lab leak- and zoonotic-origin explanations are not equally probable, and the available evidence favors the latter. ...
> The best existing scientific evidence supports a direct zoonotic origin. As new evidence continues to emerge from scientific studies or other investigations, our understanding of the origin of SARS-CoV-2 will continue to evolve. Nevertheless, it is possible that its origin may never be known with certainty. ...
> Given the currently available evidence, the two plausible possibilities for the origin of SARS-CoV-2 are not equally likely. Continuing to frame them as such does us all a disservice, dilutes our efforts, and misdirects resources—only serving to weaken our ability to respond to future pandemics.